Overzicht gehonoreerde projecten Open Ronde 2

De indeling van de projecten is gebaseerd op de vastgestelde lacunes. Zij zijn tevens ingedeeld per bijzondere patiëntengroep. Hierdoor staan enkele projecten dubbel vermeld.

Doelmatigheid en effectiviteit:

• Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care
• Anti-TNF during pregnancy: safe for growth and development of the child?
• Optimizing DMARD therapy for primary Sjogren’s syndrome
• Quality of prescribing: patient specific indicators that predict better outcomes in diabetes patients.
• Rituximab in life threatening therapy resistant progressive interstitial pneumonitis
• Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child
• Effectiveness of routine nebulisation of mucolytic agents and bronchodilating drugs in intubated and ventilated intensive care unit patients.
• Prothrombin Complex Concentrate (PCC) for the immediate reversal of the anticoagulant effects of new oral anticoagulants in emergency situations
• Co-administration of proton pump inhibitors in patients prescribed long-term low-dose aspirin: benefit, harm and cost-effectiveness
• The Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset intrauterine growth Restriction) Trial
• Risk-group Infant Vaccination Against Rotavirus (RIVAR): Phase IV effectiveness study

• A computer-assisted decision support model used for antibiotic stewardship

• Goal oriented therapy with intravenous colistin to optimally treat infections with multidrug-resistant Gram-negative bacteria (COLIGO study)

• PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients.

• The Netherlands Breast Cancer Project (NBCP): Towards personalized medicine by using the nationwide population-based breast cancer registry (1989-2011) coupled with biobanking

• Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care

• Off label use of antipsychotics in vulnerable groups: survey of prescription policy and controlled discontinuation studies in children and adolescents and in individuals with intellectual disability with disruptive behavior problems

• Clonidine als veelbelovende aanvulling op de behandeling van refractaire symptomen van schizofrenie

• Less may be more; reducing and rationalizing polypharmacy in schizophrenia

• Optimal antibiotic use: an 'antibiotic checklist' for all bacterial infections in the hospital

• Overtreatment with intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy

• Quality assessment of pharmacotherapy in patients with chronic kidney disease

• Reducing vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia by one-hour infusions instead of bolus injections

Over het gebruik van geneesmiddelen door kinderen, ouderen, zwangeren, mensen met zeldzame aandoeningen en ter voorkoming van antimicrobiële resistentie is meer wetenschappelijke onderbouwde kennis nodig.

• Anti-TNF during pregnancy: safe for growth and development of the child?

• Reducing vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia by one-hour infusions instead of bolus injections

• Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child

• PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients

• Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care

• Off label use of antipsychotics in vulnerable groups: survey of prescription policy and controlled discontinuation studies in children and adolescents and in individuals with intellectual disability with disruptive behavior problems

• Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child

• Anti-TNF during pregnancy: safe for growth and development of the child?

• Rituximab in life threatening therapy resistant progressive interstitial pneumonitis

• Overtreatment with intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy

• Optimizing DMARD therapy for primary Sjogren’s syndrome

• A computer-assisted decision support model used for antibiotic stewardship
• Goal oriented therapy with intravenous colistin to optimally treat infections with multidrug-resistant Gram-negative bacteria (COLIGO study)
• Optimal antibiotic use: an 'antibiotic checklist for all bacterial infections in the hospital
• Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care