Overzicht gehonoreerde projecten Open Ronde 1

De indeling van de projecten is gebaseerd op de vastgestelde lacunes. Zij zijn tevens ingedeeld per bijzondere patiëntengroep. Hierdoor staan enkele projecten dubbel vermeld.

• Nifedipine versus Atosiban in the treatment of threatened preterm labour: APOSTEL III
• Long term effectiveness of biological use for rheumatoid arthritis in daily clinical practice: analyses on the DREAM registry
• Cost-effectiveness of penfluridol (oral long acting neuroleptic) as compared to second generation oral neuroleptics in psychotic disorder patients: an open label randomized controlled trial.
• Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial (T4LIFE-trial)
• Paracetamol or NSAIDs in acute musculoskeletal syndromes The PanAm Study
• Ticagrelor and prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome and a high bleeding risk: optimization of antiplatelet treatment in high-risk elderly
• Patient reported outcomes in the CAstration-resistant Prostate cancer RegIstry (CAPRI)
• To treat or not to treat: depression during pregnancy and the impact on perinatal outcomes
• Prevention of venous thromboembolic complications to optimize treatment for acute lymphoblastic leukemia
• Superovulation in Intra uterine insemination: FSH or Clomifene citrate?
• Early discontinuation vs extended treatment with imipenem for unexplained fever during neutropenia in hematology patients receiving antimicrobial prophylaxis: a randomised non-inferiority trial.
• PHOlambanRElatedCArdiomyopathySTudy-intervention - PHORECAST-intervention
• HPV vaccination after treatment of anal intraepithelial neoplasia

• Shortcomings in guidelines: parameters for initiating anti-TNF in inflammatory bowel disease patients: the development of an anti-TNF decision model.

• Characterisation of the influence of (morbid) obesity on CYP3A-mediated clearance and oral absorption using midazolam as a model drug: towards evidence-based dosing in obesity.

• Treatment of patients with Fabry disease with agalsidase alfa and agalsidase beta: phenotypic diversity necessitates the development of individualized treatment guidelines.

• OPTI-CLOT: Peri-Operative PharmacokineTIc-guided dosing of CLOTting factor in Hemophilia

• Identifying the right patient to treat, by estimating absolute treatment effect for individual patients based on randomised clinical trial data

• Multicenter Randomized Double-Blind Placebo-Controlled trial of Intradiscal Methylene Blue Injection for Chronic Discogenic Low Back Pain

• CHolinEsterase inhibitors to slow progression of Visual hALlucinations in Parkinson’s disease: a multi-center placebo-controlled trial(CHEVAL)

• Population PK/PD modeling to develop and implement guidelines to optimize safe and rational dosage of critical off-label drugs in critically ill premature infants

• Low-dose dexamethasone in newly diagnosed pulmonary sarcoidosis: a low-cost treatment with favorable outcome

• Tacrolimus suppositories versus hydrocortison suppostories for the treatment of proctitis refractory to local 5-ASA.

• Concordance in pharmacotherapy in patients with epilepsy

• Personal Antipsychotic Choice Index

• Discontinuing inappropriate medication in nursing home residents (DIM-NHR study)

• Optimizing pharmacotherapy by redefining the role of the pharmacist: integration of the nondispensing pharmacist in the primary care team.

• How appropriate is the increasing long term use of methylphenidate? A practice audit and placebo controlled discontinuation trial.

• The DANCE study (Duration of ANtibiotic therapy for CEllulitis): Is 6 days of antibiotics equal to standard 12 days of treatment for cellulitis? A randomized clinical trial.

• New use of aminoglycosides: Prevention of recurrent urinary tract infections by multi-drug resistant bacteria, by intravesical administration of antibiotics.

Over het gebruik van geneesmiddelen door kinderen, ouderen, zwangeren, mensen met zeldzame aandoeningen en ter voorkoming van antimicrobiële resistentie is meer wetenschappelijke onderbouwde kennis nodig.

• How appropriate is the increasing long term use of methylphenidate? A practice audit and placebo controlled discontinuation trial.

• Population PK/PD modeling to develop and implement guidelines to optimize safe and rational dosage of critical off-label drugs in critically ill premature infants

• Treatment of patients with Fabry disease with agalsidase alfa and agalsidase beta: phenotypic diversity necessitates the development of individualized treatment guidelines.

• To treat or not to treat: depression during pregnancy and the impact on perinatal outcomes

• Ticagrelor and prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome and a high bleeding risk: optimization of antiplatelet treatment in high-risk elderly

• Discontinuing inappropriate medication in nursing home residents (DIM-NHR study)

• Optimizing pharmacotherapy by redefining the role of the pharmacist: integration of the nondispensing pharmacist in the primary care team.

• CHolinEsterase inhibitors to slow progression of Visual hALlucinations in Parkinson’s disease: a multi-center placebo-controlled trial(CHEVAL)

• Nifedipine versus Atosiban in the treatment of threatened preterm labour: APOSTEL III

• Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial (T4LIFE-trial)

• To treat or not to treat: depression during pregnancy and the impact on perinatal outcomes

• Superovulation in Intra uterine insemination: FSH or Clomifene citrate?

• Treatment of patients with Fabry disease with agalsidase alfa and agalsidase beta: phenotypic diversity necessitates the development of individualized treatment guidelines.

• Low-dose dexamethasone in newly diagnosed pulmonary sarcoidosis: a low-cost treatment with favorable outcome

• The DANCE study (Duration of ANtibiotic therapy for CEllulitis): Is 6 days of antibiotics equal to standard 12 days of treatment for cellulitis? A randomized clinical trial.

• New use of aminoglycosides: Prevention of recurrent urinary tract infections by multi-drug resistant bacteria, by intravesical administration of antibiotics.

• Early discontinuation vs extended treatment with imipenem for unexplained fever during neutropenia in hematology patients receiving antimicrobial prophylaxis: a randomised non-inferiority trial.