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resultaten gevonden voor 'Resistance'.
- Researchers will develop an in-depth problem analysis of the follow-up of patients with urinary tract infections after discharge from the ED in the Netherlands.
- The rapid spread of multidrug resistant bacteria threatens the treatment of even simple infections in the near future. However, little is known about how bacteria develop resistance on surfaces.AimThe aim of this project was to investigate fundamental mechanisms that shape antimicrobial resistance in biofilms in relation to the surface and then translate those findings into clinical practice…
- Read how the SHIELD-project strengthens natural defences through ‘trained immunity’, enabling the immune system to combat fungal infections more effectively.
- Researchers will determine the effectiveness of antibiotic stewardship programs in the intensive care unit and formulate recommendations for implementation.
- Afbeelding
In a growing number of calls for grant applications, ZonMw allows the production of FAIR (meta)data in projects. This page provides information about ZonMw's approach for this. That is followed by instructions for what grant applicants and recipients must do to get started with FAIR (meta)data. - Respiratory tract infections are common and are increasingly caused by bacteria that are no longer sensitive to commonly used antibiotics.ObjectiveThis project aimed to expand the therapeutic arsenal against respiratory tract infections by testing agents that stimulate the immune system.ResultsThe AMC had 2 specific tasks. First, a culture system of human respiratory epithelial cells was set up…
- Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
- Infections with antibiotic-resistant bacteria are a major threat to public health. Due to globalisation and poor use of antibiotics, resistance is spreading rapidly. Moreover, few new antibiotics have come onto the market in the last 20 years.AimIn this international project, researchers have been using the latest high-throughput screens to look for new combinations of drugs that can effectively…
- Read how researchers will use genome sequencing to study the fungal genus Candida in hospitals to limit its transmission.
- Project descriptionMycobacterium tuberculosis is the causative agent of tuberculosis (TB), a disease responsible for almost 1.5 million deaths per year. In recent years, different classes of drug resistant strains have emerged, making the discovery of novel tuberculostatic drugs a major priority. A major disadvantage of most existing and new TB compounds is that they target a single molecule…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
- Resistance to antibiotics is increasing worldwide and alternatives are sought for antimicrobial treatment. AimThe overall purpose was to explore and identify antibiotics and non-antibiotics more active in combination than alone (called synergism) against multi- drug resistant bacteria. The tasks of the EMC involved the overall coordination of the project, identification of synergistic combinations…