Focus area 1. Predictive diagnostics and treatment

Theme 1: Treatment

  • ReCOVer: A randomized controlled trial testing the efficacy of cognitive behavioural therapy for preventing chronic postinfectious fatigue among patients diagnosed with COVID-19 disease
    Prof. J.A. (Hans) Knoop
    Amsterdam University Medical Center - location AMC
  • BTK inhibition to prevent hyperinflammatory syndrome in COVID-19 patients
    Dr O.B.J. (Odilia) Corneth
    Erasmus Medical Center
  • COVID-19 and ischemic stroke - How to tame a dozing monster
    Prof.  F. E. (Frank-Erik) de Leeuw
    Leiden University Medical Center

Theme 2. Diagnostics of infection

  • SARSLIVA and utility of saliva in diagnosis for wide scale testing, including viral and SARS-CoV-2  antibody detection in pre- and asymptomatic persons and follow-up of infections in COVID-19 patient; a house hold study
    Dr S.F. (Steven) van Lelyveld
    Spaarne Gasthuis

Theme 3. Risk analysis and prognostics

  • Prospective cohort study of non-hospitalised COVID-19 patients: determining length of isolation and patient clinical development at home (COVID-HOME study)
    Dr A. (Adriana) Tami
    University Medical Center Groningen
  • Obesity as an amplifier of inflammation and organ injury in SARS-CoV-2 infected patients: prognostic potential and therapeutic target Thema 3:  Risicoanalyse en prognostiek
    Dr J. (Jill) Moser
    University Medical Center Groningen
  • Identification of COVID-19 patients with high Risk of mortality at ICU admiSsion – IRIS-study
    Prof. N.F. (Nicolet) de Keizer
    Nationale Intensive Care Evaluatie
  • Clinical prediction models for COVID-19: development, international validation and use
    Dr ir. D. (David) van Klaveren
    Erasmus Medical Center

Theme 4. Virus, immunity, immune response and pathogenesis

  • Integrative analysis of multi-omics longitudinal data to identify effective strategies for the prediction and treatment of COVID-19
    Dr V.K. (Vinod Kumar) Magadi Gopalaiah
    Radboud University Medical Center
  • Understanding the two faces of the COVID-19 immune response to predict clinical course and define strategies for early and late phase intervention
    Dr S. (Stefan) Nierkens and dr F (Femke) van Wijk
    University Medical Center Utrecht
  • BCG vaccination to minimise COVID-19 disease severity and duration
    T. (Thijs) ten Doesschate, MSc
    University Medical Center
  • Therapeutic inhibition of excessive lung inflammation induced by anti-SARS-CoV-2 antibodies
    Dr J. (Jeroen) den Dunnen
    Amsterdam University Medical Center - location AMC
  • Immunity against SARS-CoV-2 in immune-suppressed patients: increased risk of insufficient immunological memory or sufficient protection against re-infection?
    Prof. T.W. (Taco) Kuijpers
    Amsterdam University Medical Center - location AMC
  • Establishment and duration of protective immunity against SARS-CoV-2, in relation to severity of SARS-CoV-2 infection
    Prof. C.E. (Ellen) van der Schoot
    Sanquin Research
  • WikiPathways as a platform for COVID-19 pathway models. Identification of underlying mechanisms explaining differences in host immune response, disease severity and detection of mechanisms for targeted (drug) treatment
    Dr M. (Martina) Kutmon
    Maastricht University Medical Center+    
  • Identifying pathogenesis of COVID-19 pathology in the Dutch population and unravelling differences in pathogenetic mechanisms in high- and low-risk groups
    Dr J. (Jan) von der Thüsen
    Erasmus Medical Center
  • A virus-free high-throughput platform for studying coronavirus replication inhibitors
    Dr D. (Dirk) Eggink
    Amsterdam University Medical Center - location AMC
  • Altered IgG fucosylation driving pathologies in COVID-19: Relevance for diagnosis and therapeutics
    Dr G. (Gestur) Vidarsson
    Sanquin (Blood Supply)
  • Measuring, understanding & reducing respiratory droplet spreading
    Prof. D. (Detlef) Lohse
    University of Twente

Theme: Studies into clinical treatments

  • The COUNTER-COVID study: Oral imatinib to reverse pulmonary vascular leak and disease burden in COVID-19
    Dr HJ. (Harm-Jan) Bogaard
    Amsterdam University Medical Center - location VUmc    
  • A phase-2-study, pivotal for clinical development of lanadelumab for treatment of COVID-19
    Dr R.J.M. (Roger) Brüggemann and dr F. (Frank) van de Veerdonk
    Radboud University Medical Center
  • The PRAETORIAN-COVID study: A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease
    Dr D.H.F. (Frank) Gommans
    Netherlands Heart Institute

Theme Animal free innovations

Within theme 4 of focus area 1 (Virus, immunity, immune response and pathogenesis) the ZonMw-program More Knowledge with Fewer Animals  and the Dutch Society for the Replacement of Animal Testing  (Stichting Proefdiervrij) made extra budget available for the development of the new or wider application of existing animal-free innovations. The ultimate aim is more relevant health(care) research for humans.

  • Use of patient-relevant human lung epithelial cell models to study acute and long-term effects of COVID-19
    Prof. P.S. (Pieter) Hiemstra
    Leiden University Medical Center
  • Inhalation of Low Molecular Weight Heparins as a prophylaxis to prevent SARS-CoV-2 infection
    Prof. T.B.H. (Theo) Geijtenbeek
    Amsterdam UMC (location AMC)
  • Ex vivo models to study tissue-specific features of SARS-CoV-2 infection
    Prof. J.M. (Jeffrey) Beekman
    University Medical Center Utrecht
  • Blood Vessels-on-Chip to Understand and Target COVID-19
    Dr A.D. (Andries) van der Meer
    University of Twente
  • Employing a physiological microfluidic lung bioreactor to improve understanding of SARS-CoV2 biology and testing of therapeutics
    Dr R.J. (Robbert) Rottier
    Erasmus MC-Sophia Children’s Hospital    

Focus area 2. Care and Prevention

Theme 1: Organisation of care and prevention

  • TRACE II: Outcome in patients undergoing postponed elective surgery during the COVID-19 pandemic
    Dr J.D. (Dianne) de Korte-de Boer PhD 
    Maastricht University Medical Center+
  • COVID-19 Follow-up care paths and Long-term Outcomes Within the Dutch health care system: a combined rehabilitation, pulmonary, and intensive care perspective (CO-FLOW study)
    Dr H.J.G. (Rita) van den Berg-Emons
    Erasmus Medical Center
  • The development of a COVID-19 scoring system for effective and safe triage of patients in the primary care setting.
    Dr D.O. (Dennis) Mook-Kanamori MD PhD
    Leiden University Medical Center
  • National and regional coordination in times of scarcity
    Prof. J.T. (Taco) van der Vaart
    University of Groningen
  • Changes in the use and organization of care in general practice and out-of-hours services: lessons learned from the COVID-19 pandemic
    Dr L.L. (Lilian) Peters
    University Medical Center Groningen
  • A multidisciplinary guide for people with disability using ICT for social contact to mitigate impact of restricted in-person visit policies
    Prof. C. (Carlo) Schuengel
    VU Amsterdam
  • Effect of COVID-19 on GP care use by underrepresented patients in deprived neighbourhoods
    Dr P.L. (Paul) Kocken
    Erasmus University Rotterdam
  • Improvise, adapt, overwork? Understanding and learning from hospitals' adaptations to COVID-19 and their effects on professional functioning and recovery.
    Dr D.D. (Daan) Westra
    Maastricht University
  • Healthcare utilization in primary care during the corona pandemic: a nation-wide population-based study from a patient and healthcare provider perspective
    Dr E.I.T. (Evelien) de Schepper
    Erasmus Medical Center

Theme 2: Care and prevention for vulnerable citizens

  •  Population differences in diagnosed covid-19 prevalence in the Netherlands. Which groups are at highest risk?
    Dr E.A.L. (Ester) de Jonge
    GGD Zuid Holland Zuid
  • Homeless and COVID-19 – lessons for the future
    Prof. M.E.T.C. (Maria) van den Muijsenbergh
    Radboud University medical Center
  • Impact of COVID-19 on children and adolescents with autism spectrum disorder (ASD) and their family
    Dr L.P. (Linda) Dekker
    Erasmus University Rotterdam
  • Caring and waving: longitudinal study on the consequences of restrictive COVID-19 measures for relatives of people with intellectual disabilities and their need for support
    Dr H.R. (Hennie) Boeije
  • Consequences of restrictive measures because of COVID-19 outbreak on loneliness and social needs of residents, informal caregivers and volunteers in nursing homes
    Dr L.C. (Leonieke) van Boekel MSc
    Tilburg University
  • ICU triage during a crisis: learning from the application of medical and non-medical criteria to patient cases
    Dr A.J.M. (Anke) Oerlemans
    Radboud University Medical Center

Theme 3: Transmission and epidemiology

  • Data-driven Simulation Games for the Evaluation and Prevention of SARS-CoV-2 Transmission in Indoor Public Spaces and the Impact of Changing Compliance to Distancing Measures
    Dr Q.A. ten Bosch
    Wageningen University & Research
  • SARS-CoV-2 transmission in secondary schools and the influence of indoor environmental conditions
    Prof. P.M. (Philomena) Bluyssen
    Delft University of Technology
  • Towards Evidence-based Social Distancing Policy: Tracking Behavioral Responses to Pandemic Mitigation Measures and Implementation Strategies
    Dr M.R. (Marie Rosenkrantz) Lindegaard PhD
    Netherlands Institute for the Study of Crime and Law Enforcement
  • CONTROL (CONtact TRacing OptimaLisation): effectiveness & optimalisation of source investigation and contact tracing to limit spread of SARS-CoV-2
    Dr A.A. (Antoinette) Matser
    GGD Amsterdam
  • Serologic surveillance of SARS-CoV-2 during the 2020 pandemic in exposed and unexposed healthcare workers in a tertiary care hospital in Amsterdam (S3 study)
    Dr J.J. (Jonne) Sikkens
    Amsterdam UMC - location VUmc

Palliative care

  • Supporting family members of isolated, life-threatening ill patients with COVID-19 who have been admitted to intensive care
    Prof. B. (Bregje) Onwuteaka-Philipsen
    Amsterdam UMC, location VUmc
  • CovId-19 and SOcial isoLATion in dEmentia care (ISOLATE): impact and needs of people with dementia, informal and professional caregivers
    Dr M. (Mandy) Visser
    Leiden University Medical Center
  • The impact of the COVID-19 pandemic on death and bereavement (the CO-LIVE project)
    Dr I.J. (Ida) Korfage
    Erasmus Medical Center
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