Belgium-Netherlands Funding of International Trials 4 (BeNeFIT4 Call)
Deadline:BeNeFIT 4 Call is an international call for non-commercial practice-oriented research. It is a joint programme in which the Belgian Health Care Knowledge Centre (KCE) and ZonMw will invest 10.8 million euros together. Please read the call text for detailed information.
Who can apply
Research teams from institutions in Belgium and The Netherlands can apply to this call. Both Belgian and Dutch centres should participate, ideally with a good regional spread.
What for
The aim of the call is to provide funding for clinical trials that compare the effectiveness of existing health care interventions that are already in use for a given indication, e.g. comparisons between two medications, medical therapy versus surgery, trials investigating optimal timing of surgery etc. The research should be pragmatic and practice-oriented. The total duration of the proposed trial should be realistic and is not allowed to exceed 10 years.
What to request
There is no maximum budget per proposed trial. In total, the available budget for this call is 10.8 million euros.
When
The deadline for submission of the full research proposal is 02 September 2025, 14.00h.
| What | When |
|---|---|
| Online strengthening workshop – selected applicants only | 11 Jun 2025 |
| Deadline submission Full Research Proposal | 02 Sep 2025, 14.00h |
| Prepare rebuttal | 02 Oct 2025 |
| Deadline submission rebuttal | 16 Oct 2025, 14.00h |
| Second decision letter | End of Jan 2026 |
| Prepare feasibility exercise, final protocol & budget, and response to decision letter | 26 Jan 2026 |
| Deadline submission feasibility report, final protocol & budget, and response to decision letter | 30 Mar 2026, 14.00h |
| Award letter funding agencies | End of May 2026 |
All documents needed for the application can be found in the call text. We advise you to log in via the submission portal (Mijn ZonMw) on time to create an account and to submit the Full Research Proposal one week before the deadline via Mijn ZonMw. As this is an international call, make sure you select ‘English’ as preferred language in ‘Mijn ZonMw’. Please read the call text carefully and start preparing on time.
- For technical questions, you can contact the ZonMw Servicedesk via
servicedesk@zonmw.nl. - For content related questions, please contact benefit@zonmw.nlor
kce_trials@kce.fgov.be. - For questions related to the budget tool, please contact kce_trials@kce.fgov.be.
Please submit your Full Research Proposal and all mandatory documents via the submission portal (Mijn ZonMw).
Checklist
- Submitted before the deadline of 02 September 2025, 14:00h
- Application form and mandatory documents are in English
- Within the text fields, the specific headings are included as requested
- All mandatory documents are included
- There is at least one non-academic hospital participating in The Netherlands – or a justification if not possible
- There is at least one centre from each region participating (Flanders, Wallonia and Brussels) in Belgium – or a justification if not possible
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Features
- Opening date: 26 May 2025
- Budget subsidy round: € 10.800.000,-
-
For whom:
By invitation
-
Part of programme:
- Goed Gebruik Geneesmiddelen
- DoelmatigheidsOnderzoek
More budget available
Please note! The budget for this round has been raised from 9,2 million euros to 10.8 million euros.