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- Respiratory tract infections are common and are increasingly caused by bacteria that are no longer sensitive to commonly used antibiotics.ObjectiveThis project aimed to expand the therapeutic arsenal against respiratory tract infections by testing agents that stimulate the immune system.ResultsThe AMC had 2 specific tasks. First, a culture system of human respiratory epithelial cells was set up…
- Resistance to antibiotics is increasing worldwide and alternatives are sought for antimicrobial treatment. AimThe overall purpose was to explore and identify antibiotics and non-antibiotics more active in combination than alone (called synergism) against multi- drug resistant bacteria. The tasks of the EMC involved the overall coordination of the project, identification of synergistic combinations…
- Veel neurologische aandoeningen vertonen afwijkingen in de witte stof, waaronder multiple sclerose, schizofrenie en de ziekte van Huntington. Witte stof wordt gekenmerkt door myeline. Echter dragen vele cellulaire structuren bij aan de ontwikkeling en instandhouding van een gezonde witte stof. Terwijl veel onderzoek in proefdieren wordt gedaan, representeren deze niet de witte stof in de humane…
- Bacteria are increasingly becoming resistant to antibiotics. This is an immediate threat to health care in the Netherlands and elsewhere. Recent studies show that, in Europe alone, more than 30.000 individuals die every year due to an infection with an antibiotic-resistant bacterium.AimThis project studied the pathways by which resistant bacteria can emerge in complex ecosystems, in which they can…
- Project descriptionMycobacterium tuberculosis is the causative agent of tuberculosis (TB), a disease responsible for almost 1.5 million deaths per year. In recent years, different classes of drug resistant strains have emerged, making the discovery of novel tuberculostatic drugs a major priority. A major disadvantage of most existing and new TB compounds is that they target a single molecule…
- Living Well: avatar Anne voor mensen met dementie Door vergeetachtigheid, als gevolg van ouderdom, niet-aangeboren hersenletsel of dementie, verliezen mensen soms de controle over hun eigen leven. Daardoor raken ze de aansluiting bij de wereld om hen heen kwijt, en soms zelfs hun waardigheid. Anne, een virtuele assistent, kan uitkomst bieden voor deze groep. Hoe het werkt Voor mensen die…
- Urgent action is required to stem the spread of antimicrobial resistance (AMR). However, because the pace of novel drug development lags behind the evolution of novel AMR determinants, new strategies of containment are required.MethodIn this multinational project proposal, researchers have worked on a resistance-reversal strategy based on the concept of collateral sensitivity (CS). CS between a…
- Policies to address physical inactivity, unhealthy diets and sedentary behaviour can affect the health and well-being of many people. However, it was unknown what policy measures had been implemented in Europe, what their effect is on lifestyle behaviours, and what the consequences are for socio-economic health inequalities. Also, there had not yet been a systematic study of how policy…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
- Hospital-acquired infections, including Multidrug-resistant Enterobacteriaceae (MDR-E), are recognised to be an important public health issue and cause significant burden on health care systems worldwide. While classic infection control strategies mainly target the spread of these pathogens at intra-hospital level (inside a hospital), inter-hospital (between various hospitals and health care…
- Infections with antibiotic resistant bacteria, for example an urinary tract infections, are difficult to treat. Because of this, antibiotic resistance is an important public health threat. In Europe, the ESBL-producing gut bacteria (ESBL-G), are the most important cause of such infections, with around 400.000 cases per year. 5% of the Dutch inhabitants carries ESBL-G, while outside the Netherlands…
- Methicillin-resistant Staphylococcus aureus (MRSA) is characterised by clonal spread. MRSA clones are unequally distributed across the world and different clones are dominant at different times. AimThe MACOTRA project studied the interaction between MRSA, humans and the environment. The researchers used mathematical models to gain a better understanding of MRSA dynamics.ResultsA main predictor of…