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- Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
- Resistance to antibiotics is increasing worldwide and alternatives are sought for antimicrobial treatment. AimThe overall purpose was to explore and identify antibiotics and non-antibiotics more active in combination than alone (called synergism) against multi- drug resistant bacteria. The tasks of the EMC involved the overall coordination of the project, identification of synergistic combinations…
- Urgent action is required to stem the spread of antimicrobial resistance (AMR). However, because the pace of novel drug development lags behind the evolution of novel AMR determinants, new strategies of containment are required.MethodIn this multinational project proposal, researchers have worked on a resistance-reversal strategy based on the concept of collateral sensitivity (CS). CS between a…
- Het AMPrEP (Amsterdam PrEP) project is een onderzoek naar de toepasbaarheid van PrEP voor hiv-preventie in Nederland. PrEP is een pil met hiv-remmers die een hiv-infectie kan voorkomen. De pil is bedoeld voor mensen die geen hiv hebben, maar die wel een verhoogd risico lopen om geïnfecteerd te raken. Doel van dit project is om te onderzoeken hoe PrEP werkt in de praktijk: hoeveel mensen willen…
- Respiratory tract infections are common and are increasingly caused by bacteria that are no longer sensitive to commonly used antibiotics.ObjectiveThis project aimed to expand the therapeutic arsenal against respiratory tract infections by testing agents that stimulate the immune system.ResultsThe AMC had 2 specific tasks. First, a culture system of human respiratory epithelial cells was set up…
- In dit project is het effect onderzocht van een geprotocolleerde monitoring en behandeling van fysieke symptomen op de mate van vermoeidheid en het dagelijks functioneren van patiënten met kanker-gerelateerde vermoeidheid in de palliatieve fase van het ziektebeloop. Als onderzoeksmethode is een gerandomiseerde klinische trial gebruikt. Uit het onderzoek blijkt dat systematische registratie en…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
- T@CKLE (Transdisciplinary Analysis and Co-creation of Knowledge to Lead Efforts against Online and Offline Sexually Transgressive Behaviour and Sexual Violence) thoroughly tackles both online and offline STBSV. With an integrated and transdisciplinary approach T@CKLE brings together experts, organizations and initiatives in a new national STBSV network. With this, the collaboration across…
- PMI-AD stratifies early-stage AD patients employing a novel mechnistic pathway-to-therapeutic algorithm resulting in cost-effective diagnostics and therapeutics
- The project establishes cognitive, imaging and fluid biomarker measures that allow i) stratification of individual presymptomatic carriers into a stage near to symptom onset, and ii) measurement of disease progression during that period.
