Search on ZonMw
Search on the website
Filters
65
results found for 'Bacteria'.
- Infections caused by bacteria resistant to most antibiotics (so-called multidrug resistant bacteria) remain a global problem. The lack of new antibiotics is a major social problem and threat to human and animal health.AimIn this antimicrobial discovery project, researchers focused on developing novel antibiotics for the highly virulent and antibiotic-resistant human pathogens (called the ESKAPE…
- Bacteria are increasingly becoming resistant to antibiotics. This is an immediate threat to health care in the Netherlands and elsewhere. Recent studies show that, in Europe alone, more than 30.000 individuals die every year due to an infection with an antibiotic-resistant bacterium.AimThis project studied the pathways by which resistant bacteria can emerge in complex ecosystems, in which they can…
- The rapid spread of multidrug resistant bacteria threatens the treatment of even simple infections in the near future. However, little is known about how bacteria develop resistance on surfaces.AimThe aim of this project was to investigate fundamental mechanisms that shape antimicrobial resistance in biofilms in relation to the surface and then translate those findings into clinical practice…
- Respiratory tract infections are common and are increasingly caused by bacteria that are no longer sensitive to commonly used antibiotics.ObjectiveThis project aimed to expand the therapeutic arsenal against respiratory tract infections by testing agents that stimulate the immune system.ResultsThe AMC had 2 specific tasks. First, a culture system of human respiratory epithelial cells was set up…
- Read more about the research project on immune responses to against microbiota as biomarkers for ME/CFS.
- Bacteriophages and plasmids are often specific to a particular source, this project will investigate how CRISPR dynamics are related to environmental niche adaptation and recalibrate source attribution models.
- OASIS developed a strategy for a locally relevant AMR surveillance in human and animal populations.
- The gut microbiome—the community of bacteria and viruses in the intestines—plays a key role in the development of the immune system and in protection against viral infections. At the same time, certain viruses can disrupt both the immune system and the gut microbiome. However, the relationship between viral activity and the gut microbiome, and the role these factors play in ME/CFS, remain poorly…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
