Several non-pharmacological interventions have been shown to be effective and accepted by patients. There is yet little knowledge about the mechanisms of non-pharmacological interventions on the molecular or cellular level. For this reason, JPND launches this joint transnational call with the aim of improving the understanding of mechanisms that underlie non-pharmacological interventions.


  • Alzheimer’s disease and related disorders
  • Improving the understanding of the mechanisms and biological substrates that underlie non-pharmacological interventions.
  • A holistic personalized treatment approach

Onderdeel van programma

EU Joint Programme - Neurodegenerative Disease Research (JPND)

Geplaatst op

11 januari 2022


1 maart 2022,
15.00 uur

Purpose of call

The aim of the call is to establish a number of ambitious, innovative, multi-disciplinary and multi-national collaborative research projects that aim at understanding the biomedical, psychological and/or social mechanisms of non-pharmaceutical interventions in order to identify potential target sites for enhanced personalized interventions or a combination of pharmacological and non-pharmacological interventions.

Sums available

Proposals must focus on one or several neurodegenerative diseases. The research should focus on improving the understanding of the mechanisms and biological substrates that underlie non-pharmacological interventions in order to tailor a holistic personalized treatment approach. For assessing the well-being of people suffering from neurodegenerative diseases quality of life measures should be used. Proposals to be funded under this call will need to adequately involve patients, carers and the public. Consortia are expected to make every effort to include approaches that involve these groups.


Proposals must be hypothesis driven and should have a strong focus on methodology. They should be based on mechanistic approaches rather than pure correlational research and focused on those interventions where there is solid and demonstrable indication of effectiveness. The potential of existing cohorts should be used as much as possible. Proposals should have novel, ambitious aims and ideas combined with well-structured work plans and clearly defined objectives deliverable within three years. Gaining data on effectiveness and efficacy itself, is not within the scope of this call.

Eligible candidates 

Applicants should demonstrate that they have the expertise and range of skills required to conduct the research project or that appropriate collaborations are in place. To have an impact at European and partner country levels, it is expected that all proposals will link activities across laboratories and clinics within JPND member countries.


Total earmarked Netherlands budget:  1.800.000 €  
ZonMw has a maximum funding per project for this call: each project can request  maximum 300.000 €.


Submit application

The coordinator may submit the Pre-proposal in electronic format no later than 15:00h C.E.T. on March 1, 2022, via the JPND electronic submission systemelectronic submission system. No other means of submission will be accepted. A pre-proposal template is available at the JPND website. Adherence to this template is mandatory.
The coordinator may submit the Full proposal in electronic format no later than 15:00h C.E.S.T. on June 28, 2022, via the electronic submission system.

Download all information (Add pdf online with full call document)
Understanding the mechanisms of non-pharmacological interventions call (pdf)

More information can be found on the JPND.EU site

ZonMw-programma Joint Programming Initiative Neurodegenerative Diseases (JPND)

European website JPND Research


Please contact us with any questions that are not covered in the FAQs. For general queries, please contact Abida Durrani (

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Abida Durrani

ZonMw, Senior Programme Manager

+31 (0) 70 34 95 239
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