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Human measurement models
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- … Replacing animal experiments by direct measurement of DNA damage responses in human tumor slices ex vivo Afgerond Looptijd 102013 092017 … relies heavily on animal experiments Both murine tumor models and xenografts in mice are commonly used for drug …
- … with Prof Martin Röösli validation of the Dutch geospatial model of radio frequency electromagnetic field exposure and crosscomparability of measurements with Swiss data Afgerond Looptijd 092010 032012 … conducted and their application in studies of risks to human health … Collaboration with Prof Martin Röösli …
- … modeling of Parkinson039s disease with threedimensional human midbrain organoids Afgerond Looptijd 052016 092019 … heeft in een Europees samenwerkingsverband een nieuw modelsysteem voor de ziekte van Parkinson ontwikkeld Door … of onset and progression under physiologically relevant measurement conditions Moreover by the usage of …
- … Human pericytestabilized microvesselsonachip a novel option … cells Due to the complexity of this process animal models are increasingly used to study microvascular … systems modeling that will allow translation from measurements from our microvesselonachip platform to …
- … to mature electrophysiological characteristics of human stem cell derived cardiomyocytes a new competitive … heart rhythm drugs are tested in preclinical testing models with increasing complexity beginning with drugtarget … of the cells standardized the conditions for measurements and showed that the system is sensitive and …
- … In vitro genotoxicity test using metabolic competent 3D human bronchial epithelial model as alternative to in vivo … Om hierin veranderingnbsp te brengen heeft het LUMC een in vitromodel ontwikkeld dat sterk overeenkomt met het … are still sufficient proliferating cells to allow sensitive measurement of genotoxicity by the integration of the …
- … Small plastic particles in the human foetal environment novel studies on exposure and … Experimental studies with human ex vivo placental perfusion models indicate that SPPs in particular particles in the low … thermal hydrolysis for depolymerization of SPPs with measurement by ultrahighresolution mass spectrometry HRM …
- Afbeelding
… acronym MKMD we encourage the development of new animalfree models and the acceptance and implementation of existing … … Kennisinfrastructuur … LS&H … proefdiervrijetechnieken … Humanefibrosemodellen … openaccess … openscience … FAIRdata … Health Foundations SGF Dutch Research Council NWO Human Measurement Models Dutch Research Agenda NWA Netherlands … - Afbeelding
… In doing so we strive to achieve better results for humans and ultimately better treatments and drugs … What are … or skin Consequently they are valuable and representative models for research With these human measurement models we can conduct better and more … - … mechanistic knowledge of toxicant action using human cells as biological basis and leveraging the recent … and transcriptome responses 4 computational pathway models that can relate cellular stress response pathways to … of toxic outcome We have the vision that dynamic measurements of relevant stress responses in combination …
- … 3500 recognized cases Two years before the first documented human outbreak in 2007 abortion waves were reported on a … from donating blood 6 Combine exposure and doseresponse models to estimate geographical distribution of risks and … maps with be related to case clustering and validated by measurement of C burnetii in air and the environment The …
- … and their relative concentration in a farmenvironmentalhumanpatient sample by fingerprinting in animal populations … to exposed neighboring residents using existing emission models and refine these approaches by combining measurements and modeling 5 Create regional maps that …