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Artikel
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Titel: Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients
Auteur(s): Kristine Germar PhD Cynthia M. Fehres PhD Hans U. Scherer MD, PhD Nathalie van Uden Sabrina Pollastro PhD Nataliya Yeremenko PhD Monika Hansson Priscilla F. Kerkman PhD Ellen I. H. van der Voort Evan Reed PhD Hanna Maassen Mark J. Kwakkenbos PhD Arjen Q. Bakker Lars Klareskog PhD Vivianne Malmström PhD Niek de Vries MD, PhD René E. M. Toes PhD Karin Lundberg PhD Hergen Spits PhD Dominique L. Baeten MD, PhD
Tijdschrift: Arthritis and Rheumatology
Start- en eindpagina: 340 - 350
Publicatiedatum: 01-10-2018
DOI: 10.1002/art.40739

Titel: Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications
Auteur(s): T Kissel, S Reijm, LM Slot, M Cavallari, CM Wortel, RD Vergroesen, G Stoeken-Rijsbergen, JC Kwekkeboom, Kampstra, EWN Levarht, JW Drijfhout, H Bang, KM Bonger, GMC Janssen, PA van Veelen, TWJ Huizinga, HU Scherer, M Reth, REM Toes
Tijdschrift: Annals of the Rheumatic Diseases
Start- en eindpagina: 472 - 480
Publicatiedatum: 10-02-2020
DOI: 10.1136/annrheumdis-2019-216499

Titel: On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis
Auteur(s): Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom WJ Huizinga, Hans Ulrich Scherer, René Toes, Solbritt Rantapää-Dahlqvist
Tijdschrift: Annals of the Rheumatic Diseases
Start- en eindpagina: 1616 - 1620
Publicatiedatum: 30-08-2019
DOI: 10.1136/annrheumdis-2019-215698

Titel: N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development
Auteur(s): Rochelle D Vergroesen 1 , Linda M Slot 1 , Barbera D C van Schaik 2 , Marvyn T Koning 3 , Theo Rispens 4 , Antoine H C van Kampen 2 5 , René E M Toes 1 , Hans U Scherer 1
Tijdschrift: Frontiers in Immunology
Start- en eindpagina: 2019 - 2019
Publicatiedatum: 04-09-2019
DOI: 10.3389/fimmu.2019.02092

Titel: N-Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis
Auteur(s): Lise Hafkenscheid MSc Emma de Moel MD Irene Smolik PhD Stacey Tanner MD Xiaobo Meng PhD Bas C. Jansen PhD Albert Bondt PhD Manfred Wuhrer PhD Tom W. J. Huizinga MD, PhD Rene E. M. Toes PhD Hani El-Gabalawy MD Hans U. Scherer MD, PhD
Tijdschrift: Arthritis and Rheumatology
Start- en eindpagina: 1626 - 1636
Publicatiedatum: 08-05-2019
DOI: 10.1002/art.40920

Titel: The B cell response to citrullinated antigens in the development of rheumatoid arthritis
Auteur(s): Scherer, Hans Ulrich, Huizinga, Tom W. J., Krönke, Gerhard, Schett, Georg, Toes, Rene E. M.
Tijdschrift: Nature Reviews Rheumatology
Start- en eindpagina: 157 - 169
Publicatiedatum: 08-02-2018
DOI: 10.1038/nrrheum.2018.10

Titel: Adaptive antibody diversification throughN-linked glycosylation of the immunoglobulin variable region
Auteur(s): van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Ooijevaar-de Heer, Pleuni, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo
Tijdschrift: Proceedings of the National Academy of Sciences
Start- en eindpagina: 1901 - 1906
Publicatiedatum: 05-02-2018
DOI: 10.1073/pnas.1711720115

Titel: Variable domain glycosylation of ACPA-IgG: A missing link in the maturation of the ACPA response?
Auteur(s): Kempers, Ayla C., Hafkenscheid, Lise, Scherer, Hans Ulrich, Toes, René E.M.
Tijdschrift: Clinical Immunology
Start- en eindpagina: 34 - 37
Publicatiedatum: 20-02-2018
DOI: doi: 10.1016/j.clim.2017.09.001

Titel: Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis
Auteur(s): Kerkman PF, Fabre E, van der Voort EI, Zaldumbide A, Rombouts Y, Rispens T, Wolbink G, Hoeben RC, Spits H, Baeten DL, Huizinga TW, Toes RE, Scherer HU
Tijdschrift: Annals of the Rheumatic Diseases
Start- en eindpagina: 11706 - 1176
Publicatiedatum: 01-06-2015
DOI: 10.1136/annrheumdis-2014-207182

Titel: Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies
Auteur(s): Kerkman PF, Kempers AC, van der Voort EI, van Oosterhout M, Huizinga TW, Toes RE, Scherer HU.
Tijdschrift: Annals of Rheumatic Diseases
Start- en eindpagina: 2201 - 2207
Publicatiedatum: 11-04-2016
DOI: 10.1136/annrheumdis-2015-208554

Titel: B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation.
Auteur(s): Vergroesen RD, Slot LM, Hafkenscheid L, Koning MT, van der Voort EIH, Grooff CA, Zervakis G, Veelken H, Huizinga TWJ, Rispens T, Scherer HU, Toes REM.
Tijdschrift: Annals of the Rheumatic Diseases
Start- en eindpagina: 52 - 55
Publicatiedatum: 23-08-2017
DOI: 10.1136/annrheumdis-2017-212052

Titel: Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans
Auteur(s): Hafkenscheid L, Bondt A, Scherer HU, Huizinga TW, Wuhrer M, Toes RE, Rombouts Y
Tijdschrift: Molecular and Cellular Proteomics
Start- en eindpagina: 278 - 287
Publicatiedatum: 01-02-2017
DOI: 10.1074/mcp.M116.062919

Presentatie
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Titel: Cross reactivity as an inducer of autoimmunity
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 03-06-2020
URL:https://www.eular.org/congress.cfm

Titel: Auto-antibody modification – Turning up the heat
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 13-02-2020
URL:https://kuleuvencongres.be/ewrr2020/home

Titel: Tertiary lymphoid structures and B cells in inflammation and cancer
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 26-03-2020
URL:https://www.lumc.nl/over-het-lumc/nieuws/2020/Maart

Titel: Take the bitter with the sweet; on the role of variable domain glycans and the breach of tolerance of auto-reactive B-cells in Rheumatoid Arthritis
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 03-06-2019

Titel: Anti-Modified Protein Antibodies in (pre-)RA; on antigen-reactivity and glycosylation
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 08-11-2019
URL:https://acrabstracts.org/

Titel: Autoreactive B cells and antibodies in the pre-RA phase of disease; on glycosylation and antigen-reactivity
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 25-09-2019
URL:https://fnih.org/what-we-do/programs/ifra2019

Titel: Glycosylation of antibodies in autoimmune diseases
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 10-09-2019
URL:https://www.gfid-ev.de/dsa.htm

Titel: Post-translational modifications of antibodies: Where there is smoke, there is fire
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 12-06-2019
URL:https://www.eular.org/

Titel: Take the bitter with the sweet; on the role of variable domain glycans and the breach of tolerance of auto-reactive B-cells in Rheumatoid Arthritis
Auteur(s): Scientific presentation by Prof Toes
Publicatiedatum: 29-05-2019
URL:https://www.humanimmunology.org/about/

Titel: Post-translational modified protein antibodies in RA: searching for the eye of the storm
Auteur(s): Rene Toes
Publicatiedatum: 03-09-2018

Titel: Zooming in on autoreactive B cell responses in RA
Auteur(s): Rene Toes
Publicatiedatum: 02-05-2018

Titel: B cells in Rheumatoid Arthritis
Auteur(s): Rene Toes
Publicatiedatum: 16-07-2018
URL:https://bcellnetwork.nl/2018/

Titel: Emerging biomarkers in Rheumatoid Arthritis
Auteur(s): Rene Toes
Publicatiedatum: 10-10-2018
URL:http://www.precisionmedicineautoimmunity.org/

Titel: The introduction of N-linked glycans in the variable domain of Anti-NVVI 2017: Citrullinated Protein Antibodies marks the development of Rheumatoid Arthritis
Auteur(s): Lise Hafkenscheid
Publicatiedatum: 13-12-2017
URL:https://www.dutchsocietyimmunology.nl/

Titel: Extensive glycosylation of ACPA-IgG variable domains in rheumatoid arthritis
Auteur(s): Lise Hafkenscheid
Publicatiedatum: 07-12-2016

Titel: Extensive glycosylation of ACPA-IgG variable domains in rheumatoid arthritis
Auteur(s): Lise Hafkenscheid
Publicatiedatum: 19-11-2016

Titel: Extensive glycosylation of ACPA-IgG variable domains in rheumatoid arthritis
Auteur(s): Lise Hafkenscheid
Publicatiedatum: 23-06-2016

Titel: N-glycosylation sites in the variable domain of B cell receptors specific for citrullinated antigens
Auteur(s): H.U. Scherer
Publicatiedatum: 14-06-2017

Titel: Alterations in the antibody repertoire and sugar modulation as cause for autoimmunity
Auteur(s): H.U. Scherer
Publicatiedatum: 14-06-2017

Titel: B Cell Receptor Sequencing of Anti-Citrullinated Protein Antibody (ACPA-)expressing B Cells Indicates a Selective Advantage For The Introduction of N-Glycosylation Sites During Somatic Hypermutation
Auteur(s): H.U. Scherer
Publicatiedatum: 03-11-2017

Titel: Autoantibodies and their glycosylation during emergence of RA
Auteur(s): H.U. Scherer
Publicatiedatum: 23-09-2017

Titel: Extensive glycosylation of ACPA-IgG variable domains in rheumatoid arthritis
Auteur(s): Lise Hafkenscheid
Publicatiedatum: 19-11-2016

Titel: N-glycosylation sites in anti-citrullinated protein antibody (ACPA-) expressing B-cell receptors are selectively introduced at high frequency during somatic hypermutation
Auteur(s): Rochelle Vergroesen
Publicatiedatum: 13-12-2017

Titel: Introduction of N-glycosylation sites in ACPA-IgG B cells
Auteur(s): Rochelle Vergroesen
Publicatiedatum: 23-09-2017

Prijs/onderscheiding
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Titel: Carol Nachman Prize 2018
Publicatiedatum: 02-07-2018
URL:https://www.wiesbadener-kurier.de/lokales/wiesbaden/

Proefschrift
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Titel: Identification and characterization of anti-citrullinated protein antibody-producing B clls en patients with Rheumatoid Arthritis
Auteur(s): Priscilla F. Kerkman
Publicatiedatum: 18-04-2017

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