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Beyond clinical diagnosis: the prognostic value of unrequested information in diagnostic imaging

Projectomschrijving

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Titel: Lung Cancer Screening CT-Based Prediction of Cardiovascular Events.
Auteur: Mets OM, Vliegenthart R, Gondrie MJ, Viergever MA, Oudkerk M, de Koning HJ, Mali WP, Prokop M, van Klaveren RJ, van der Graaf Y, Buckens CF, Zanen P, Lammers JW, Groen HJ, Isgum I, de Jong PA
Magazine: JACC Cardiovasc Imaging
Titel: Prevalence of incidental findings in computed tomographic screening of the chest: a systematic review.
Auteur: Jacobs PC, Mali WP, Grobbee DE, van der Graaf Y.
Titel: Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans.
Auteur: Mets OM, Buckens CF, Zanen P, Isgum I, van Ginneken B, Prokop M, Gietema HA, Lammers JW, Vliegenthart R, Oudkerk M, van Klaveren RJ, de Koning HJ, Mali WP, de Jong PA.
Magazine: Journal of the American Medical Association
Titel: Comparing coronary artery calcium and thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on low-dose non-gated computed tomography in a high-risk population of heavy smokers.
Auteur: Jacobs PC, Prokop M, van der Graaf Y, Gondrie MJ, Janssen KJ, de Koning HJ,Isgum I, van Klaveren RJ, Oudkerk M, van Ginneken B, Mali WP
Magazine: Atherosclerosis
Titel: ntra and interobserver reliability and agreement of semiquantitative vertebral fracture assessment on chest computed tomography.
Auteur: Buckens CF, de Jong PA, Mol C, Bakker E, Stallman HP, Mali WP, van der Graaf Y, Verkooijen HM.
Magazine: PLoS ONE
Titel: Anabolic androgenic steroid use is associated with ventricular dysfunction on cardiac MRI in strength trained athletes
Auteur: Luijkx T, Velthuis BK, Backx FJ, Buckens CF, Prakken NH, Rienks R, Mali WP, Cramer MJ.
Magazine: International Journal of Cardiology
Titel: Ethnic differences in ventricular hypertrabeculation on cardiac MRI in elite football players.
Auteur: Luijkx T, Cramer MJ, Zaidi A, Rienks R, Senden PJ, Sharma S, van Hellemondt FJ, Buckens CF, Mali WP, Velthuis BK.
Magazine: Netherlands Heart Journal
Titel: Impact of cardiovascular calcifications on the detrimental effect of continued smoking on cardiovascular risk in male lung cancer screening participants
Auteur: Jairam PM, de Jong PA, Mali WP, Isgum I, de Koning HJ, van der Aalst C, Oudkerk M, Vliegenthart R, van der Graaf Y. Impact of cardiovascular calcifications on the detrimental effect of continued smoking on cardiovascular risk in male lung cancer screening participants.
Magazine: PLoS ONE
Titel: The prognostic value of vascular diameter measurements on routine chest computed tomography in patients not referred for cardiovascular indications
Auteur: Gondrie MJ, van der Graaf Y, Jacobs PC, Buckens SC Mali WP, the PROVIDI Study Group.
Magazine: Journal of Computer Assisted Tomography
Titel: Prediction of cardiovascular events by using non-vascular findings on routine chest CT.
Auteur: de Jong PA, Gondrie MJ, Buckens CF, Jacobs PC, Mali WP, van der Graaf Y
Magazine: PLoS ONE
Titel: Coronary artery calcium can predict all-cause mortality and cardiovascular events on low-dose CT screening for lung cancer
Auteur: Jacobs PC, Gondrie MJ, van der Graaf Y, de Koning HJ, Isgum I, van Ginneken B, Mali WP
Magazine: American Journal of Roentgenology
Titel: The prognostic value of unrequested Information in Diagnostic Imaging (PROVIDI) Study: rationale and design.
Auteur: Gondrie MJ, Mali WP, Buckens CF, Jacobs PC, Grobbee DE, van der Graaf Y.
Magazine: European Journal of Epidemiology
Titel: Unrequested information from routine diagnostic chest CT predicts future cardiovascular events
Auteur: Jacobs PC, Gondrie MJ, Mali WP, Oen AL, Prokop M, Grobbee DE, van der Graaf Y
Magazine: European Radiology
Titel: The association of incidentally detected heart valve calcification with future cardiovascular events
Auteur: Gondrie MJ, van der Graaf Y, Jacobs PC, Oen AL, Mali WP
Magazine: European Radiology
Titel: Sport category is an important determinant of cardiac adaptation: an MRI study
Auteur: Luijkx T, Cramer MJ, Prakken NH, Buckens CF, Mosterd A, Rienks R, Backx FJ, Mali WP, Velthuis BK
Magazine: British Journal of Sports Medicine
Titel: Semiquantitative assessment of cardiovascular disease markers in multislice computed tomography of the chest: interobserver and intraobserver agreements.
Auteur: Jacobs PC, Prokop M, Oen AL, van der Graaf Y, Grobbee DE, Mali WP
Magazine: Journal of Computer Assisted Tomography
Titel: Cardiovascular disease: prediction with ancillary aortic findings on chest CT scans in routine practice.
Auteur: Gondrie MJ, Mali WP, Jacobs PC, Oen AL, van der Graaf Y; PROVIDI Study Group.
Magazine: Radiology
Titel: A simple adaptation method improved the interpretability of prediction models for composie end points
Auteur: Gondrie MJ, Janssen KJ, van der Graaf Y
Magazine: Journal of Clinical Epidemiology
Titel: Prevalence of incidental findings in computed tomographic screening of the chest: a systematic review.
Auteur: Jacobs PC, Mali WP, Grobbee DE, van der Graaf Y.
Magazine: Journal of Computer Assisted Tomography
Titel: Diagnosis of chronic obstructive pulmonary disease in lung cancer screening Computed Tomography scans: independent contribution of emphysema, air trapping and bronchial wall thickening
Auteur: Mets OM, Schmidt M, Buckens CF, Gondrie MJ, Isgum I, Oudkerk M, Vliegenthart R, de Koning HJ, van der Aalst CM, Prokop M, Lammers JW, Zanen P, Hoesein FA, Mali WP, van Ginneken B, van Rikxoort EM, de Jong PA
Magazine: Respiratory Research
Titel: Visual versus automated evaluation of chest computed tomography for the presence of chronic obstructive pulmonary disease.
Auteur: Mets OM, Smit EJ, Mohamed Hoesein FA, Gietema HA, Bokkers RP, Attrach M, van Amelsvoort-van de Vorst S, Scholten ET, Buckens CF, Oudkerk M, Lammers JW, Prokop M, de Jong PA.
Magazine: PLoS ONE
Titel: Coronary artery calcification scoring in low-dose ungated CT screening for lung cancer: interscan agreement.
Auteur: Jacobs PC, Isgum I, Gondrie MJ, Mali WP, van Ginneken B, Prokop M, van der Graaf Y.
Magazine: American Journal of Roentgenology
Titel: Unrequested findings on cardiac computed tomography: looking beyond the heart.
Auteur: Buckens CF, Verkooijen HM, Gondrie MJ, Jairam P, Mali WP, van der Graaf Y.
Magazine: PLoS ONE
Titel: Vascular calcifications as prognostic markers of CVD events in chest CT
Auteur: Jacobs PC
Link: http://igitur-archive.library.uu.nl/dissertations/2010-0122-200246/jacobs.pdf
Titel: Unrequested imaging findings on routine chest CT : results from the PROVIDI study
Auteur: Gondrie M.J.A.
Link: http://igitur-archive.library.uu.nl/dissertations/2011-0314-200310/gondrie.pdf

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Samenvatting van de aanvraag

Imaging plays a key role in diagnosis. Over 9 million investigations are performed annually in the Netherlands. Advances in imaging technology over the last decade have provided the opportunity to abstract prognostic information from multislice Computed Tomography (msCT) scans obtained for diagnostic reasons. This is often referred to as ancillary (unrequested) information. Currently, these imaging characteristics are largely ignored because their relevance is not known nor quantified. In this project, we will investigate the extent to which unrequested imaging findings are of prognostic relevance for the occurence of several relevant diseases, other than those clinically indicated. Using a case-cohort approach, we will follow up 20.000 patients with an indication for chest msCT. The msCT of all patients who experience a cardiovascular event, hip or vertebral fracture or lung disease (cases) and of a random sample of the baseline cohort (controls) will be retrieved and assessed with regard to information about a) known pathology, b) abnormalities of unknown relevance and c)other imaging findings. These imaging characteristics will be used together with clinical characteristics and routine classification of CT to construct prognostic models to predict future morbidity and mortality (cardiovascular, hip and vertebral fracture and admission for lung cancer or chronic obstructive pulmonary disease). The derived predictors will then be prospectively validated in patients not included in the derivation cohort. The novelty of the proposal lies in the recognition that imaging data obtained to serve a particular diagnostic purpose in daily clinical practice not only contain information related to the original indication, but also ancillary information of potential clinical benefit. It will identify which imaging information is medically relevant to patients and their physicians and which information is normal and should not lead to therapeutic intervention. The approach and findings may serve as a role model for other diagnostic techniques.

Onderwerpen

Kenmerken

Projectnummer:
91207005
Looptijd: 100%
Looptijd: 100 %
2007
2013
Onderdeel van programma:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Prof. dr. Y. van der Graaf
Verantwoordelijke organisatie:
Universitair Medisch Centrum Utrecht