Current guidelines for the prevention of osteoporosis are relatively vague, reflecting the large uncertainties surrounding treatment. In the recent past, we developed basic models to simulate the costs and effects of the prevention and treatment of osteoporosis and we propose to further refine and validate those models. Within them, we propose to include other risk indicators such as propensity to fall, visual impairment, use of walking aids, drug usage and co-morbidity in general, and also to consider other fractures than merely hip fractures, as well as other morbidity related to cardio-vascular disease and cancer.
At the end, the models aim to reduce the current uncertainty surrounding the question whether the prevention of osteoporosis and osteoporotic fractures can be cost-effective, taking a broad perspective considering various related diseases. Who should be treated, and when and how should we do this? Different scenarios will be compared and the most cost-effective options selected for incorporation in future guidelines.