Understanding how diet modifies cognitive ageing represents the next frontiers for developing interventions. To this end it is key to (i) elucidate the combination of nutrients capable of modulating cognitive decline via the ability of the brain to be plastic and (ii) identify vulnerable populations. We think that the influence of diet on the brain occurs throughout life and that we should consider exposure to stress/genetic predisposition as vulnerability factors. We propose a project across the field of nutrition, epidemiology, and neuroscience.
We aim to identify (i) a combination of dietary compounds protecting against cognitive ageing and (ii) a population responding to the impact of diet on cognitive decline; and to provide (iii) evidence of brain plasticity as targets for nutrients intervention and (iv) a proof-of-principle life-long dietary intervention for preventing/rescuing cognitive decline. This will open entirely new avenues for dietary interventions for cognitive decline.