In de tweede open subsidieronde Goed Gebruik Geneesmiddelen zijn 69 uitgewerkte aanvragen ingediend. Uiteindelijk is aan 24 projecten subsidie verstrekt. Het totale subsidie bedrag bedraagt circa € 7,5 miljoen. De indeling van de projecten is gebaseerd op de vastgestelde lacunes. Zij zijn tevens ingedeeld per bijzondere patiëntengroep. Hierdoor staan enkele projecten dubbel vermeld.
Doelmatigheid en effectiviteit:
- Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care (nr. 836021002)
- Anti-TNF during pregnancy: safe for growth and development of the child? (nr. 836021004)
- Optimizing DMARD therapy for primary Sjogren’s syndrome (nr. 836021005)
- Quality of prescribing: patient specific indicators that predict better outcomes in diabetes patients (nr. 836021007)
- Rituximab in life threatening therapy resistant progressive interstitial pneumonitis (nr. 836021009)
- Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child (nr. 836021011)
- Pregnancy immunoglobulin for the prevention of congenital cytomegalovirus infection (PICCOLO) (nr. 836021014)
- Effectiveness of routine nebulisation of mucolytic agents and bronchodilating drugs in intubated and ventilated intensive care unit patients (nr. 836021016)
- Prothrombin Complex Concentrate (PCC) for the immediate reversal of the anticoagulant effects of new oral anticoagulants in emergency situations (nr. 836021017)
- Co-administration of proton pump inhibitors in patients prescribed long-term low-dose aspirin: benefit, harm and cost-effectiveness (nr. 836021018)
- The Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset intrauterine growth Restriction) Trial (nr. 836021023)
- Risk-group Infant Vaccination Against Rotavirus (RIVAR): Phase IV effectiveness study (nr. 836021024)
Farmacotherapie op maat:
- A computer-assisted decision support model used for antibiotic stewardship (nr. 836021021)
- Goal oriented therapy with intravenous colistin to optimally treat infections with multidrug-resistant Gram-negative bacteria (COLIGO study) (nr. 836021008)
- PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients (nr. 836021012)
- The Netherlands Breast Cancer Project (NBCP): Towards personalized medicine by using the nationwide population-based breast cancer registry (1989-2011) coupled with biobanking (nr. 836021019)
- Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care (nr. 836021022)
Off-label:
Nieuwe indicaties:
Polyfarmacie:
Over- en onderbehandeling:
- Optimal antibiotic use: an 'antibiotic checklist' for all bacterial infections in the hospital (nr. 836021001)
- Overtreatment with intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy (nr. 836021010)
- Quality assessment of pharmacotherapy in patients with chronic kidney disease (nr. 836021013)
Toedieningsvormen:
Bijzondere groepen:
Over het gebruik van geneesmiddelen door kinderen, ouderen, zwangeren, mensen met zeldzame aandoeningen en ter voorkoming van antimicrobiële resistentie is meer wetenschappelijke onderbouwde kennis nodig.
Kinderen:
- Anti-TNF during pregnancy: safe for growth and development of the child? (nr. 836021004)
- Reducing vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia by one-hour infusions instead of bolus injections (nr. 836021006)
- Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child (nr. 836021011)
- PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients (nr. 836021012)
- Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care (nr. 836021022)
- Off label use of antipsychotics in vulnerable groups: survey of prescription policy and controlled discontinuation studies in children and adolescents and in individuals with intellectual disability with disruptive behavior problems (nr. 836021020)
Zwangeren:
- Tapering antidepressants in pregnancy: a pragmatic multicenter RCT to investigate risk and benefits for mother and child (nr. 836021011)
- Anti-TNF during pregnancy: safe for growth and development of the child? (nr. 836021004)
- Pregnancy immunoglobulin for the prevention of congenital cytomegalovirus infection (PICCOLO) (nr. 836021014)
Zeldzame aandoeningen:
- Rituximab in life threatening therapy resistant progressive interstitial pneumonitis (nr. 836021009)
- Overtreatment with intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy (nr. 836021010)
- Optimizing DMARD therapy for primary Sjogren’s syndrome (nr. 836021005)
Antimicrobiële resistentie:
- A computer-assisted decision support model used for antibiotic stewardship (nr. 836021021)
- Goal oriented therapy with intravenous colistin to optimally treat infections with multidrug-resistant Gram-negative bacteria (COLIGO study) (nr. 836021008)
- Optimal antibiotic use: an 'antibiotic checklist for all bacterial infections in the hospital (nr. 836021001)
- Childhood Infections Limburg (CHILI): Optimizing management and medication of febrile children in out-of-hours primary care (nr. 836021022)