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Artikel
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Titel: Simulation-based suggestions to improve dosing for patent ductus arteriosus in preterm newborns
Auteur(s): Flint,R.B.; Ter Heine,R.; Spaans,E.; Burger,D.M.; De Klerk,J.; Allegaert,K.; Knibbe,C.A.J.; Simons,S.H.P.
Tijdschrift: European Journal of Clinical Pharmacology
Start- en eindpagina: 0 - 0
Publicatiedatum: 30-04-2018

Titel: A population pharmacokinetic model for fentanyl in preterm born infants
Auteur(s): Voller,S; Flint,R.B.; Andriessen,P.; Allegaert,K.; Zimmermann,L.J.I.; Liem,K.D.; Koch,B.C.P.; Knibbe,C.A.J.; Simons,S.H.P.
Tijdschrift: Archives of Disease in Childhood - Fetal and Neonatal Edition
Start- en eindpagina: 0 - 0
Publicatiedatum: 12-07-2018

Titel: Simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram in plasma using liquid chromatography-tandem mass spectrometry
Auteur(s): Flint, Robert B., Bahmany, Soma, van der Nagel, Bart C. H., Koch, Birgit C. P.
Tijdschrift: Biomedical Chromatography
Start- en eindpagina: 1 - 8
Publicatiedatum: 12-06-2018
DOI: 10.1002/bmc.4290

Titel: Large differences in neonatal drug use between NICUs are common practice: time for consensus?
Auteur(s): Flint, Robert B., van Beek, Floor, Andriessen, Peter, Zimmermann, Luc J., Liem, Kian D., Reiss, Irwin K.M., de Groot, Ronald, Tibboel, Dick, Burger, David M., Simons, Sinno H.P.
Tijdschrift: British Journal of Clinical Pharmacology
Start- en eindpagina: 1313 - 1323
Publicatiedatum: 17-04-2018
DOI: 10.1111/bcp.13563

Titel: Therapeutic Drug Monitoring in Neonates: What Makes them Unique?
Auteur(s): Mian, P., Flint, R. B., Tibboel, D., N. van den Anker, J., Allegaert, K., Koch, B. C.P.
Tijdschrift: Current Pharmaceutical Design
Start- en eindpagina: 5790 - 5800
Publicatiedatum: 09-02-2018
DOI: 10.2174/1381612823666170926143820

Titel: Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants
Auteur(s): Flint, Robert B., Weteringen, Willem van, Völler, Swantje, Poppe, Jarinda A., Koch, Birgit C.P., Groot, Ronald de, Tibboel, Dick, Knibbe, Catherijne A.J., Reiss, Irwin K.M., Simons, Sinno H.P., DINO Research group, Bentham Science Publisher
Tijdschrift: Current Pharmaceutical Design
Start- en eindpagina: 5919 - 5927
Publicatiedatum: 09-02-2018
DOI: 10.2174/1381612823666170918121556

Titel: Exposure to acetaminophen and all its metabolites upon 10, 15 and 20 mg/kg intravenous acetaminophen in very preterm infants
Auteur(s): Flint, Robert B, Roofthooft, Daniella W, van Rongen, Anne, van Lingen, Richard A, van den Anker, Johannes N, van Dijk, Monique, Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A J, Simons, Sinno H P
Tijdschrift: Pediatric Research
Start- en eindpagina: 678 - 684
Publicatiedatum: 29-05-2017
DOI: 10.1038/pr.2017.129

Titel: Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation
Auteur(s): Völler, Swantje, Flint, Robert B., Stolk, Leo M., Degraeuwe, Pieter L.J., Simons, Sinno H.P., Pokorna, Paula, Burger, David M., de Groot, Ronald, Tibboel, Dick, Knibbe, Catherijne A.J.
Tijdschrift: European Journal of Pharmaceutical Sciences
Start- en eindpagina: 90 - 97
Publicatiedatum: 12-05-2017
DOI: 10.1016/j.ejps.2017.05.026

Titel: Retrospective study shows that doxapram therapy avoided the need for endotracheal intubation in most premature neonates
Auteur(s): Flint, Robert, Halbmeijer, Nienke, Meesters, Naomi, van Rosmalen, Joost, Reiss, Irwin, van Dijk, Monique, Simons, Sinno
Tijdschrift: Acta Paediatrica
Start- en eindpagina: 733 - 739
Publicatiedatum: 01-03-2017
DOI: 10.1111/apa.13761

Titel: Quantification of Acetaminophen and Its Metabolites in Plasma Using UPLC-MS
Auteur(s): Flint, Robert B., Mian, Paola, van der Nagel, Bart, Slijkhuis, Nuria, Koch, Birgit C. P.
Tijdschrift: Therapeutic Drug Monitoring
Start- en eindpagina: 164 - 171
Publicatiedatum: 27-01-2017
DOI: 10.1097/FTD.0000000000000379

Presentatie
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Titel: A population pharmacokinetic model for phenobarbital in term and preterm newborns
Auteur(s): S Völler, RB Flint, LM Stolk, PLJM Degraeuwe, SHP Simons, DM Burger, CAJ Knibbe
Publicatiedatum: 11-11-2016

Titel: Doxapram therapy in newborns; shoult we still use it?
Auteur(s): Flint, Robert, Halbmeijer, Nienke, Meesters, Naomi, van Rosmalen, Joost, Reiss, Irwin, van Dijk, Monique, Simons, Sinno
Publicatiedatum: 09-04-2015

Titel: New simulation based ibuprofen dosage regimen for ?Patent Ductus Arteriosus in ?Preterm Newborns
Auteur(s): R.Flint
Publicatiedatum: 04-11-2017

Titel: Pharmacokinetic and pharmacodynamic studies aiming for rational drug dosing in preterm neonates: the DINO study
Auteur(s): S.Voller
Publicatiedatum: 03-11-2017

Titel: Large differences in off-label and neonatal drug use still exist: ?time for consensus??
Auteur(s): R.B. Flint1, F. Van Beek, P.Andriessen, L.Zimmermann, D. Liem, I.K.M. Reiss, R. de Groot, D. Tibboel, D.M. Burger, S.H.P. Simons, DINO study group
Publicatiedatum: 03-11-2017

Titel: Big data analyses for continuous evaluation of pharmacotherapy: ??A proof of principle with doxapram in preterm infants
Auteur(s): R.B.Flint, W. van Weteringen, S. Völler, J.A. Poppe, B.C.P. Koch, R. de Groot, D. Tibboel, C.A.J. Knibbe, I.K.M. Reiss, S.H.P. Simons
Publicatiedatum: 01-11-2017

Titel: Doxapram therapy in newborns; should we still use it?
Auteur(s): Flint, Robert, Halbmeijer, Nienke, Meesters, Naomi, van Rosmalen, Joost, Reiss, Irwin, van Dijk, Monique, Simons, Sinno
Publicatiedatum: 10-11-2016

Titel: Analyses of current unlicensed and off-label for age drug prescriptions at a Neonatal Intensive Care Unit
Auteur(s): R.B. Flint, S.H.P. Simons, D.M. Burger, I.K.M. Reiss, R. de Groot, D. Tibboel
Publicatiedatum: 13-11-2015

Titel: Doxapram therapy in newborns; should we still use it?
Auteur(s): Flint, Robert, Halbmeijer, Nienke, Meesters, Naomi, van Rosmalen, Joost, Reiss, Irwin, van Dijk, Monique, Simons, Sinno
Publicatiedatum: 19-09-2015

Titel: De blauwdruk voor PK/PD onderzoek in de kindergeneeskunde
Auteur(s): D.H. Nuytemans; R.B. Flint
Publicatiedatum: 05-11-2015

Titel: Use of second-to-second physiological monitoring data for continuous evaluation of pharmacotherapy in preterm infants: an application to the respiratory stimulant doxapram
Auteur(s): J.A. Poppe, W. van Weteringen, R.B. Flint, T.G. Goos, I.K.M. Reiss, S.H.P. Simons, C.A.J. Knibbe, S.Völler
Publicatiedatum: 30-05-2018

Titel: Pharmacokinetics of ibuprofen in very preterm infants with patent ductus arteriosus
Auteur(s): A.G.J. Engbers, R.B. Flint, S. Völler, J. de Klerk, I. Reiss, P. Andriessen, K.D. Liem, P.L.J. Degraeuwe, S. Croubels, J. Millecam, K.M. Allegaert, C.A.J. Knibbe, S.H.P. Simons
Publicatiedatum: 30-05-2018

Titel: A population pharmacokinetic model for phenobarbital in term and preterm newbors
Auteur(s): S Völler, RB Flint, LM Stolk, PLJM Degraeuwe, SHP Simons, DM Burger, CAJ Knibbe
Publicatiedatum: 08-05-2017

Titel: Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants
Auteur(s): R.B.Flint, W. van Weteringen, S. Völler, J.A. Poppe, B.C.P. Koch, R. de Groot, D. Tibboel, C.A.J. Knibbe, I.K.M. Reiss, S.H.P. Simons
Publicatiedatum: 07-05-2017

Titel: ANALYSES OF CURRENT UNLICENSED AND OFF-LABEL FOR AGE DRUG PRESCRIPTIONS AT A NEONATAL INTENSIVE CARE UNIT
Auteur(s): R.B. Flint, S.H.P. Simons, D.M. Burger, I.K.M. Reiss, R. de Groot, D. Tibboel
Publicatiedatum: 19-10-2014

Titel: A BLUE-PRINT FOR PERFORMING PAEDIATRIC PHARMACOLOGICAL RESEARCH
Auteur(s): Vermeulen, Eric, Nuytemans, Debbie, de Haan, Timo, Flint, Robert, der Lee, Johanna van
Publicatiedatum: 14-12-2015

Titel: Analyses of current unlicensed and off-label for age drug prescriptions at A Neonatal Intensive Care Unit
Auteur(s): R.B. Flint a, b, S.H.P. Simons a, D.M. Burger b, I.K.M. Reiss a, R. de Groot c, D. Tibboel d
Publicatiedatum: 16-06-2014

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