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Inmiddels loopt het project Personalized blended care for depression with comorbid alcohol misuse among young people: a multi-centre RCT ruim twee jaar. In die twee jaar hebben we in samenwerking met voormalige en huidige ggz clienten in behandeling voor een depressie een digitale interventie ontwikkeld gericht op het verminderen van het alcoholgebruik. Hiervoor zijn we een samenwerking aangegaan met Jellinek. Dit heeft geleid tot de ontwikkeling van een nieuwe digitale alcoholinterventie op maat gemaakt voor clieten met een depressieve stoornis: Beating the Booze (


De interventie is ontwikkeld en wordt nu onderzocht in de praktijk. De interventie wordt aangeboden aan clienten die binnenkort voor een depressieve stoornis in behandeling gaan. De komende maanden werken we aan het werven van voldoende deelnemers aan het onderzoek zodat we in de resterende tijd van het project kunnen onderzoeken of de digitale alcoholinterventie inderdaad doet wat deze zou moeten doen.

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* Beating the Booze -





* Schouten MJE. Online self-help for young adults with co-occurring alcohol misuse and depression: intervention development & study design. EASAR 2019 Conference (European Association of Substance Abuse Research), 19 mei 2019, Lake Valence, Hongarije.


* Blankers M, Schouten MJE. Alcohol E-health voor depressieve jongeren. 6e Wetenschapssymposium Arkin, 7 november 2019, Amsterdam, Nederland.


* Schouten MJE, Olthof M, Blankers M, Goudriaan AE. Tafelgesprek Ehealth. Jellinek Symposium 2020 Yes We Connect! 10 maart 2020, Amsterdam, Nederland.





* Schouten MJE, Christ C, Dekker JJM, Riper H, Goudriaan AE, Blankers M. (2020). Digital Interventions for People with Co-occurring Depression and Problematic Alcohol Use: a Systematic Review and Meta-analysis. In review (13-AUG-2020).


* Christ C, Schouten MJE, Blankers M, van Schaik DJ, Beekman AT, Wisman MA, Stikkelbroek YAJ, Dekker JJM. (2020). Internet and Computer-based Cognitive Behavioral Therapy for Anxiety and Depression in Adolescents and Young Adults: A Systematic Review and Meta-analysis. J Med Internet Res. 2020 Jun 21. doi: 10.2196/17831.


Samenvatting van de aanvraag

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Many studies have found that consuming alcohol to cope with distress or to escape problems plays a fundamental role in the development of problematic drinking in young people including students with depressive symptoms or depression. Combined treatment of comorbid alcohol problems and MDD could hence be vitally important from a clinical and a public health viewpoint (Riper et al 2014), especially for adolescents and young adults. However, evidence on the effectiveness, and the availability of combined depression and alcohol interventions tailored at young people is currently insufficient.


Therefore, the threefold aim of this project is:


1. To develop - in collaboration with patient experts - online, cognitive behavioural therapy / motivational interviewing (CBT/MI) based alcohol reduction add-on modules tailored for young people (incl. students) in depression therapy;


2. To test the (cost-) effectiveness of treatment as usual + internet-based alcohol reduction add-on modules on alcohol and depression outcomes against treatment as usual (TAU) in a multi-centre randomized clinical trial (RCT);


3. To prepare and execute an implementation plan to foster the wider use of alcohol reduction add-on modules when successful outcomes of the RCT are found.


Objective RCT:

To reduce depression symptoms and alcohol intake simultaneously in a population of young adults with a depressive disorder and problematic alcohol use.


Primary outcome variable:

Positive clinical treatment outcome in this trial (treatment response) is defined as:


(a) Drinking less than 21 (males) / 14 (females) standard alcohol drinks in the week prior to measurement;

(b) 0 days with 4 or more (women), or 5 or more (men) drinks reported in the last 7 days;

(c) Center for Epidemiological Studies-Depression (CES-D) score < 16 or reduced by 40% relative to CES-D at baseline.


The primary clinical endpoint assessment is 6 months post-randomization. For the cost-effectiveness analyses, all outcomes up until 12 months will be used.


Patients (n=156) will enrol in this RCT from two sites in Amsterdam (NL): Arkin and GGZ inGeest.


The primary outcome -treatment response- is assessed 3, 6 (primary) and 12 months post-randomization. For the cost-effectiveness analyses, all outcomes up until 12 months will be used.


An implementation plan will be developed in collaboration with patient organizations. If successful, the add-on modules will be integrated in clinical practice.


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