Translocation of intestinal Ralstonia pickettii as driver of visceral adipose tissue inflammation and subsequent insulin resistance
Projectomschrijving
Overgewicht veroorzaakt vaak een ontsteking van het buikvetweefsel. Deze ontsteking bevordert het ontstaan van suikerziekte
bij mensen met overgewicht. In dit Vidi projectvheeft mijn groep van onderzoekers proberen te ontrafelen of
darmbacteriën (en specifiek de darmpathogenen zoals Ralstonia Pickettii) de bron van deze ontsteking vormen en of specifieke
behandeling met een feces transplantatie een mogelijke behandeling is voor vetweefselontsteking en insuline resistentie. We
hebben door middel van donor fecestransplantaties aangetoond dat darmbacteriën inderdaad een rol spelen in
suikerhuishouding en vetweefsel ontsteking. Bovendien hebben we in de HELIUS-cohort studie gevonden dat mensen van
verschillende ethniciteiten die in Amsterdam wonen allemaal een andere darmbacterie samenstelling hebben en dat dit ook
deels verbonden is met overgewicht, metabool syndroom/type 2 diabetes. Tenslotte hebben we meer inzicht gekregen in de
onderliggende (B cell immunologische) mechanismen over hoe darmbacteriën ons (vetweefsel) metabolisme verstoren.
Producten
Titel: Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome
Auteur: Smits, Loek P., Kootte, Ruud S., Levin, Evgeni, Prodan, Andrei, Fuentes, Susana, Zoetendal, Erwin G., Wang, Zeneng, Levison, Bruce S., Cleophas, Maartje C. P., Kemper, E. Marleen, Dallinga-Thie, Geesje M., Groen, Albert K., Joosten, Leo A. B., Netea, Mihai G., Stroes, Erik S. G., de Vos, Willem M., Hazen, Stanley L., Nieuwdorp, Max
Magazine: Journal of the American Heart Association
Auteur: Smits, Loek P., Kootte, Ruud S., Levin, Evgeni, Prodan, Andrei, Fuentes, Susana, Zoetendal, Erwin G., Wang, Zeneng, Levison, Bruce S., Cleophas, Maartje C. P., Kemper, E. Marleen, Dallinga-Thie, Geesje M., Groen, Albert K., Joosten, Leo A. B., Netea, Mihai G., Stroes, Erik S. G., de Vos, Willem M., Hazen, Stanley L., Nieuwdorp, Max
Magazine: Journal of the American Heart Association
Titel: Potential of butyrate to influence food intake in mice and men
Auteur: Fluitman, Kristina S, Wijdeveld, Madelief, Nieuwdorp, Max, IJzerman, Richard G
Magazine: Gut
Auteur: Fluitman, Kristina S, Wijdeveld, Madelief, Nieuwdorp, Max, IJzerman, Richard G
Magazine: Gut
Titel: Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
Auteur: van Baar, Annieke C G, Prodan, Andrei, Wahlgren, Camilla D, Poulsen, Steen S, Knop, Filip K, Groen, Albert K, Bergman, Jacques J, Nieuwdorp, Max, Levin, Evgeni
Magazine: Endocrine
Auteur: van Baar, Annieke C G, Prodan, Andrei, Wahlgren, Camilla D, Poulsen, Steen S, Knop, Filip K, Groen, Albert K, Bergman, Jacques J, Nieuwdorp, Max, Levin, Evgeni
Magazine: Endocrine
Titel: Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial
Auteur: Reijnders, Dorien, Goossens, Gijs H., Hermes, Gerben D.A., Neis, Evelien P.J.G., van der Beek, Christina M., Most, Jasper, Holst, Jens J., Lenaerts, Kaatje, Kootte, Ruud S., Nieuwdorp, Max, Groen, Albert K., Olde Damink, Steven W.M., Boekschoten, Mark V., Smidt, Hauke, Zoetendal, Erwin G., Dejong, Cornelis H.C., Blaak, Ellen E.
Magazine: Cell Metabolism
Auteur: Reijnders, Dorien, Goossens, Gijs H., Hermes, Gerben D.A., Neis, Evelien P.J.G., van der Beek, Christina M., Most, Jasper, Holst, Jens J., Lenaerts, Kaatje, Kootte, Ruud S., Nieuwdorp, Max, Groen, Albert K., Olde Damink, Steven W.M., Boekschoten, Mark V., Smidt, Hauke, Zoetendal, Erwin G., Dejong, Cornelis H.C., Blaak, Ellen E.
Magazine: Cell Metabolism
Titel: Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Auteur: Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groe
Magazine: Cell Metabolism
Auteur: Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groe
Magazine: Cell Metabolism
Titel: SGLT2 Inhibition in the Diabetic Kidney—From Mechanisms to Clinical Outcome
Auteur: van Bommel, Erik J.M., Muskiet, Marcel H.A., Tonneijck, Lennart, Kramer, Mark H.H., Nieuwdorp, Max, van Raalte, Daniel H.
Magazine: Clinical Journal of the American Society of Nephrology
Auteur: van Bommel, Erik J.M., Muskiet, Marcel H.A., Tonneijck, Lennart, Kramer, Mark H.H., Nieuwdorp, Max, van Raalte, Daniel H.
Magazine: Clinical Journal of the American Society of Nephrology
Titel: Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Auteur: Scheithauer, Torsten P.M., Dallinga-Thie, Geesje M., de Vos, Willem M., Nieuwdorp, Max, van Raalte, Daniël H.
Magazine: Molecular metabolism
Auteur: Scheithauer, Torsten P.M., Dallinga-Thie, Geesje M., de Vos, Willem M., Nieuwdorp, Max, van Raalte, Daniël H.
Magazine: Molecular metabolism
Titel: Targeted inhibition of gut microbiota proteins involved in
TMAO
production to reduce platelet aggregation and arterial thrombosis: a blueprint for drugging the microbiota in the treatment of cardiometabolic disease?
Auteur: Mens, T. E., Büller, H. R., Nieuwdorp, M.
Magazine: Journal of Thrombosis and Haemostasis
Auteur: Mens, T. E., Büller, H. R., Nieuwdorp, M.
Magazine: Journal of Thrombosis and Haemostasis
Titel: The Duodenum harbors a Broad Untapped Therapeutic Potential
Auteur: van Baar, Annieke C.G., Nieuwdorp, Max, Holleman, Frits, Soeters, Maarten R., Groen, Albert K., Bergman, Jacques J.G.H.M.
Magazine: Gastroenterology
Auteur: van Baar, Annieke C.G., Nieuwdorp, Max, Holleman, Frits, Soeters, Maarten R., Groen, Albert K., Bergman, Jacques J.G.H.M.
Magazine: Gastroenterology
Titel: Consensus report: faecal microbiota transfer - clinical applications and procedures
Auteur: König, J., Siebenhaar, A., Högenauer, C., Arkkila, P., Nieuwdorp, M., Norén, T., Ponsioen, C. Y., Rosien, U., Rossen, N. G., Satokari, R., Stallmach, A., de Vos, W., Keller, J., Brummer, R. J.
Magazine: Alimentary Pharmacology and Therapeutics
Auteur: König, J., Siebenhaar, A., Högenauer, C., Arkkila, P., Nieuwdorp, M., Norén, T., Ponsioen, C. Y., Rosien, U., Rossen, N. G., Satokari, R., Stallmach, A., de Vos, W., Keller, J., Brummer, R. J.
Magazine: Alimentary Pharmacology and Therapeutics
Titel: The Duodenum harbors a Broad Untapped Therapeutic Potential
Auteur: van Baar, Annieke C.G., Nieuwdorp, Max, Holleman, Frits, Soeters, Maarten R., Groen, Albert K., Bergman, Jacques J.G.H.M.
Magazine: Gastroenterology
Auteur: van Baar, Annieke C.G., Nieuwdorp, Max, Holleman, Frits, Soeters, Maarten R., Groen, Albert K., Bergman, Jacques J.G.H.M.
Magazine: Gastroenterology
Titel: Emerging role of intestinal microbiota and microbial metabolites in metabolic control
Auteur: Herrema, Hilde, IJzerman, Richard G., Nieuwdorp, Max
Magazine: Diabetologica
Auteur: Herrema, Hilde, IJzerman, Richard G., Nieuwdorp, Max
Magazine: Diabetologica
Titel: The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Demirkiran, Ahmet, van Wagensveld, Bart A., Ackermans, Mariette T., Verheij, Joanne, Romijn, Johannes A., Nieuwdorp, Max, Maratos-Flier, Eleftheria, Herman, Mark A., Serlie, Mireille J.
Magazine: Molecular metabolism
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Demirkiran, Ahmet, van Wagensveld, Bart A., Ackermans, Mariette T., Verheij, Joanne, Romijn, Johannes A., Nieuwdorp, Max, Maratos-Flier, Eleftheria, Herman, Mark A., Serlie, Mireille J.
Magazine: Molecular metabolism
Titel: An evaluation of the therapeutic potential of fecal microbiota transplantation to treat infectious and metabolic diseases
Auteur: Groen, Albert K, Nieuwdorp, Max
Magazine: EMBO Journal
Auteur: Groen, Albert K, Nieuwdorp, Max
Magazine: EMBO Journal
Titel: Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration
Auteur: van der Valk, Fleur M., van Wijk, Diederik F., Lobatto, Mark E., Verberne, Hein J., Storm, Gert, Willems, Martine C.M., Legemate, Dink A., Nederveen, Aart J., Calcagno, Claudia, Mani, Venkatesh, Ramachandran, Sarayu, Paridaans, Maarten P.M., Otten, Maarten J., Dallinga-Thie, Geesje M., Fayad, Zahi A., Nieuwdorp, Max, Schulte, Dominik M., Metselaar, Josbert M., Mulder, Willem J.M., Stroes, Erik S.
Magazine: Nanomedicine
Auteur: van der Valk, Fleur M., van Wijk, Diederik F., Lobatto, Mark E., Verberne, Hein J., Storm, Gert, Willems, Martine C.M., Legemate, Dink A., Nederveen, Aart J., Calcagno, Claudia, Mani, Venkatesh, Ramachandran, Sarayu, Paridaans, Maarten P.M., Otten, Maarten J., Dallinga-Thie, Geesje M., Fayad, Zahi A., Nieuwdorp, Max, Schulte, Dominik M., Metselaar, Josbert M., Mulder, Willem J.M., Stroes, Erik S.
Magazine: Nanomedicine
Titel: “Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans”
Auteur: Meijnikman, Abraham S, Gerdes, Victor E, Nieuwdorp, Max, Herrema, Hilde
Magazine: Endocrine Review
Auteur: Meijnikman, Abraham S, Gerdes, Victor E, Nieuwdorp, Max, Herrema, Hilde
Magazine: Endocrine Review
Titel: GLP1, an Important Regulator of Intestinal Lipid Metabolism
Auteur: Dallinga-Thie, G. M., Nieuwdorp, M.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Auteur: Dallinga-Thie, G. M., Nieuwdorp, M.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Titel: Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives
Auteur: Groen, Robin N., de Clercq, Nicolien C., Nieuwdorp, Max, Hoenders, H. J. Rogier, Groen, Albert K.
Magazine: Critical Reviews in Biochemistry and Molecular Biology
Auteur: Groen, Robin N., de Clercq, Nicolien C., Nieuwdorp, Max, Hoenders, H. J. Rogier, Groen, Albert K.
Magazine: Critical Reviews in Biochemistry and Molecular Biology
Titel: Smits MM, Tonneijck L, Muskiet MH, Hoekstra T, Kramer MH, Diamant M, Nieuwdorp M, Groen AK, Cahen DL, van Raalte DH.
Auteur: Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients.
Magazine: Diabetes, Obesity and Metabolism
Auteur: Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients.
Magazine: Diabetes, Obesity and Metabolism
Titel: Gut Microbiota in Obesity and Undernutrition
Auteur: de Clercq, Nicolien C, Groen, Albert K, Romijn, Johannes A, Nieuwdorp, Max
Magazine: Annual review of nutrition
Auteur: de Clercq, Nicolien C, Groen, Albert K, Romijn, Johannes A, Nieuwdorp, Max
Magazine: Annual review of nutrition
Titel: Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy
Auteur: Schnitzler, Johan G., Bernelot Moens, Sophie J., Tiessens, Feiko, Bakker, Guido J., Dallinga-Thie, Geesje M., Groen, Albert K., Nieuwdorp, Max, Stroes, Erik S. G., Kroon, Jeffrey
Magazine: Journal of Lipid Research
Auteur: Schnitzler, Johan G., Bernelot Moens, Sophie J., Tiessens, Feiko, Bakker, Guido J., Dallinga-Thie, Geesje M., Groen, Albert K., Nieuwdorp, Max, Stroes, Erik S. G., Kroon, Jeffrey
Magazine: Journal of Lipid Research
Titel: Effect of Single Dose of RANKL Antibody Treatment on Acute Charcot Neuro-osteoarthropathy of the Foot.
Auteur: Busch-Westbroek TE, Delpeut K, Balm R, Bus SA, Schepers T, Peters EJ, Smithuis FF, Maas M, Nieuwdorp M.
Magazine: Diabetes Care
Auteur: Busch-Westbroek TE, Delpeut K, Balm R, Bus SA, Schepers T, Peters EJ, Smithuis FF, Maas M, Nieuwdorp M.
Magazine: Diabetes Care
Titel: SGLT2 Inhibition in the Diabetic Kidney—From Mechanisms to Clinical Outcome
Auteur: van Bommel, Erik J.M., Muskiet, Marcel H.A., Tonneijck, Lennart, Kramer, Mark H.H., Nieuwdorp, Max, van Raalte, Daniel H.
Magazine: Clinical Journal of the American Society of Nephrology
Auteur: van Bommel, Erik J.M., Muskiet, Marcel H.A., Tonneijck, Lennart, Kramer, Mark H.H., Nieuwdorp, Max, van Raalte, Daniel H.
Magazine: Clinical Journal of the American Society of Nephrology
Titel: Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Auteur: Koh, Ara, Molinaro, Antonio, Ståhlman, Marcus, Khan, Muhammad Tanweer, Schmidt, Caroline, Mannerås-Holm, Louise, Wu, Hao, Carreras, Alba, Jeong, Heeyoon, Olofsson, Louise E., Bergh, Per-Olof, Gerdes, Victor, Hartstra, Annick, de Brauw, Maurits, Perkins, Rosie, Nieuwdorp, Max, Bergström, Göran, Bäckhed, Fredrik
Magazine: Cellular Microbiology
Auteur: Koh, Ara, Molinaro, Antonio, Ståhlman, Marcus, Khan, Muhammad Tanweer, Schmidt, Caroline, Mannerås-Holm, Louise, Wu, Hao, Carreras, Alba, Jeong, Heeyoon, Olofsson, Louise E., Bergh, Per-Olof, Gerdes, Victor, Hartstra, Annick, de Brauw, Maurits, Perkins, Rosie, Nieuwdorp, Max, Bergström, Göran, Bäckhed, Fredrik
Magazine: Cellular Microbiology
Titel: Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
Auteur: Bouter, Kristien E., van Raalte, Daniël H., Groen, Albert K., Nieuwdorp, Max
Magazine: Gastroenterology
Auteur: Bouter, Kristien E., van Raalte, Daniël H., Groen, Albert K., Nieuwdorp, Max
Magazine: Gastroenterology
Titel: Noninvasive Differentiation between Hepatic Steatosis and Steatohepatitis with MR Imaging Enhanced with USPIOs in Patients with Nonalcoholic Fatty Liver Disease: A Proof-of-Concept Study.
Auteur: Smits LP, Coolen BF, Panno MD, Runge JH, Nijhof WH, Verheij J, Nieuwdorp M, Stoker J, Beuers UH, Nederveen AJ, Stroes ES.
Magazine: Radiology
Auteur: Smits LP, Coolen BF, Panno MD, Runge JH, Nijhof WH, Verheij J, Nieuwdorp M, Stoker J, Beuers UH, Nederveen AJ, Stroes ES.
Magazine: Radiology
Titel: Effective Electroconvulsive Therapy in a Patient With Psychotic Depression With Active Cushing Disease
Auteur: van Rooijen, Geeske, Denys, Damiaan, Fliers, Eric, Nieuwdorp, Max
Magazine: Journal of Affective Disorders
Auteur: van Rooijen, Geeske, Denys, Damiaan, Fliers, Eric, Nieuwdorp, Max
Magazine: Journal of Affective Disorders
Titel: Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Auteur: Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groe
Magazine: Cell Metabolism
Auteur: Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groe
Magazine: Cell Metabolism
Titel: Hepatic Diacylglycerol-Associated Protein Kinase Ce Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Versteeg, Ruth I., Ackermans, Mariette T., Nederveen, Aart J., la Fleur, Susanne E., Romijn, Johannes A., Nieuwdorp, Max, Zhang, Dongyan, Samuel, Varman T., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I., Serlie, Mireille J.
Magazine: Cell Reports
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Versteeg, Ruth I., Ackermans, Mariette T., Nederveen, Aart J., la Fleur, Susanne E., Romijn, Johannes A., Nieuwdorp, Max, Zhang, Dongyan, Samuel, Varman T., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I., Serlie, Mireille J.
Magazine: Cell Reports
Titel: Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion
Auteur: Jakulj, Lily, van Dijk, Theo H., de Boer, Jan Freark, Kootte, Ruud S., Schonewille, Marleen, Paalvast, Yared, Boer, Theo, Bloks, Vincent W., Boverhof, Renze, Nieuwdorp, Max, Beuers, Ulrich H.W., Stroes, Erik S.G., Groen, Albert K.
Magazine: Cell Metabolism
Auteur: Jakulj, Lily, van Dijk, Theo H., de Boer, Jan Freark, Kootte, Ruud S., Schonewille, Marleen, Paalvast, Yared, Boer, Theo, Bloks, Vincent W., Boverhof, Renze, Nieuwdorp, Max, Beuers, Ulrich H.W., Stroes, Erik S.G., Groen, Albert K.
Magazine: Cell Metabolism
Titel: Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
Auteur: Neal, Bruce, Perkovic, Vlado, Mahaffey, Kenneth W., de Zeeuw, Dick, Fulcher, Greg, Erondu, Ngozi, Shaw, Wayne, Law, Gordon, Desai, Mehul, Matthews, David R.
Magazine: New England Journal of Medicine
Auteur: Neal, Bruce, Perkovic, Vlado, Mahaffey, Kenneth W., de Zeeuw, Dick, Fulcher, Greg, Erondu, Ngozi, Shaw, Wayne, Law, Gordon, Desai, Mehul, Matthews, David R.
Magazine: New England Journal of Medicine
Titel: 9.
Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans.
Auteur: van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES.
Magazine: Circulation
Auteur: van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES.
Magazine: Circulation
Titel: Predictive value of targeted proteomics for coronary plaque morphology in patients with suspected coronary artery disease.
Auteur: Bom MJ, Levin E, Driessen RS, Danad I, Van Kuijk CC, van Rossum AC, Narula J, Min JK, Leipsic JA, Belo Pereira JP, Taylor CA, Nieuwdorp M, Raijmakers PG, Koenig W, Groen AK, Stroes ESG, Knaapen P.
Magazine: EBioMedicine
Auteur: Bom MJ, Levin E, Driessen RS, Danad I, Van Kuijk CC, van Rossum AC, Narula J, Min JK, Leipsic JA, Belo Pereira JP, Taylor CA, Nieuwdorp M, Raijmakers PG, Koenig W, Groen AK, Stroes ESG, Knaapen P.
Magazine: EBioMedicine
Titel: Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Auteur: Li, S. S., Zhu, A., Benes, V., Costea, P. I., Hercog, R., Hildebrand, F., Huerta-Cepas, J., Nieuwdorp, M., Salojarvi, J., Voigt, A. Y., Zeller, G., Sunagawa, S., de Vos, W. M., Bork, P.
Magazine: Science
Auteur: Li, S. S., Zhu, A., Benes, V., Costea, P. I., Hercog, R., Hildebrand, F., Huerta-Cepas, J., Nieuwdorp, M., Salojarvi, J., Voigt, A. Y., Zeller, G., Sunagawa, S., de Vos, W. M., Bork, P.
Magazine: Science
Titel: Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography
Auteur: Deschasaux, Mélanie, Bouter, Kristien E., Prodan, Andrei, Levin, Evgeni, Groen, Albert K., Herrema, Hilde, Tremaroli, Valentina, Bakker, Guido J., Attaye, Ilias, Pinto-Sietsma, Sara-Joan, van Raalte, Daniel H., Snijder, Marieke B., Nicolaou, Mary, Peters, Ron, Zwinderman, Aeilko H., Bäckhed, Fredrik, Nieuwdorp, Max
Magazine: Nature Medicine
Auteur: Deschasaux, Mélanie, Bouter, Kristien E., Prodan, Andrei, Levin, Evgeni, Groen, Albert K., Herrema, Hilde, Tremaroli, Valentina, Bakker, Guido J., Attaye, Ilias, Pinto-Sietsma, Sara-Joan, van Raalte, Daniel H., Snijder, Marieke B., Nicolaou, Mary, Peters, Ron, Zwinderman, Aeilko H., Bäckhed, Fredrik, Nieuwdorp, Max
Magazine: Nature Medicine
Titel: Fecal microbiota transplantation against intestinal colonization by extended spectrum beta-lactamase producing Enterobacteriaceae: a proof of principle study
Auteur: Singh, Ramandeep, de Groot, Pieter F., Geerlings, Suzanne E., Hodiamont, Caspar J., Belzer, Clara, Berge, Ineke J. M. ten, de Vos, Willem M., Bemelman, Frederike J., Nieuwdorp, Max
Magazine: BMC Research Notes
Auteur: Singh, Ramandeep, de Groot, Pieter F., Geerlings, Suzanne E., Hodiamont, Caspar J., Belzer, Clara, Berge, Ineke J. M. ten, de Vos, Willem M., Bemelman, Frederike J., Nieuwdorp, Max
Magazine: BMC Research Notes
Titel: The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Demirkiran, Ahmet, van Wagensveld, Bart A., Ackermans, Mariette T., Verheij, Joanne, Romijn, Johannes A., Nieuwdorp, Max, Maratos-Flier, Eleftheria, Herman, Mark A., Serlie, Mireille J.
Magazine: Molecular metabolism
Auteur: ter Horst, Kasper W., Gilijamse, Pim W., Demirkiran, Ahmet, van Wagensveld, Bart A., Ackermans, Mariette T., Verheij, Joanne, Romijn, Johannes A., Nieuwdorp, Max, Maratos-Flier, Eleftheria, Herman, Mark A., Serlie, Mireille J.
Magazine: Molecular metabolism
Titel: Testing the sympathetic nervous system of the foot has a high predictive value for early amputation in patients with diabetes with a neuroischemic ulcer
Auteur: Schreuder, Sanne M, Nieuwdorp, M, Koelemay, Marc J W, Bipat, Shandra, Reekers, Jim A
Magazine: BMJ Open
Auteur: Schreuder, Sanne M, Nieuwdorp, M, Koelemay, Marc J W, Bipat, Shandra, Reekers, Jim A
Magazine: BMJ Open
Titel: Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction.
Auteur: Bouter KE, van Raalte DH, Groen AK, Nieuwdorp M.
Magazine: Gastroenterology
Auteur: Bouter KE, van Raalte DH, Groen AK, Nieuwdorp M.
Magazine: Gastroenterology
Titel: Insulin resistance in obesity can be reliably identified from fasting plasma insulin
Auteur: ter Horst, K W, Gilijamse, P W, Koopman, K E, de Weijer, B A, Brands, M, Kootte, R S, Romijn, J A, Ackermans, M T, Nieuwdorp, M, Soeters, M R, Serlie, M J
Magazine: International Journal of Obesity
Auteur: ter Horst, K W, Gilijamse, P W, Koopman, K E, de Weijer, B A, Brands, M, Kootte, R S, Romijn, J A, Ackermans, M T, Nieuwdorp, M, Soeters, M R, Serlie, M J
Magazine: International Journal of Obesity
Titel: The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
Auteur: Aydin, Ömrüm, Nieuwdorp, Max, Gerdes, Victor
Magazine: Current Diabetes Reports
Auteur: Aydin, Ömrüm, Nieuwdorp, Max, Gerdes, Victor
Magazine: Current Diabetes Reports
Titel: Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice
Auteur: Udayappan, Shanthadevi, Manneras-Holm, Louise, Chaplin-Scott, Alice, Belzer, Clara, Herrema, Hilde, Dallinga-Thie, Geesje M, Duncan, Silvia H, Stroes, Erik S G, Groen, Albert K, Flint, Harry J, Backhed, Fredrik, de Vos, Willem M, Nieuwdorp, Max
Magazine: Nature Microbiology
Auteur: Udayappan, Shanthadevi, Manneras-Holm, Louise, Chaplin-Scott, Alice, Belzer, Clara, Herrema, Hilde, Dallinga-Thie, Geesje M, Duncan, Silvia H, Stroes, Erik S G, Groen, Albert K, Flint, Harry J, Backhed, Fredrik, de Vos, Willem M, Nieuwdorp, Max
Magazine: Nature Microbiology
Titel: European consensus conference on faecal microbiota transplantation in clinical practice
Auteur: Cammarota, Giovanni, Ianiro, Gianluca, Tilg, Herbert, Rajilic-Stojanovic, Mirjana, Kump, Patrizia, Satokari, Reetta, Sokol, Harry, Arkkila, Perttu, Pintus, Cristina, Hart, Ailsa, Segal, Jonathan, Aloi, Marina, Masucci, Luca, Molinaro, Antonio, Scaldaferri, Franco, Gasbarrini, Giovanni, Lopez-Sanroman, Antonio, Link, Alexander, de Groot, Pieter, de Vos, Willem M, Högenauer, Christoph, Malfertheiner, Peter, Mattila, Eero, Milosavljevic, Tomica, Nieuwdorp, Max, Sanguinetti, Maurizio, Simren, Magnu
Magazine: Gut
Auteur: Cammarota, Giovanni, Ianiro, Gianluca, Tilg, Herbert, Rajilic-Stojanovic, Mirjana, Kump, Patrizia, Satokari, Reetta, Sokol, Harry, Arkkila, Perttu, Pintus, Cristina, Hart, Ailsa, Segal, Jonathan, Aloi, Marina, Masucci, Luca, Molinaro, Antonio, Scaldaferri, Franco, Gasbarrini, Giovanni, Lopez-Sanroman, Antonio, Link, Alexander, de Groot, Pieter, de Vos, Willem M, Högenauer, Christoph, Malfertheiner, Peter, Mattila, Eero, Milosavljevic, Tomica, Nieuwdorp, Max, Sanguinetti, Maurizio, Simren, Magnu
Magazine: Gut
Titel: Impaired insulin action in the liver, but not in adipose tissue or muscle, is a distinct metabolic feature of impaired fasting glucose in obese humans.
Auteur: Ter Horst KW, Gilijamse PW, Ackermans MT, Soeters MR, Nieuwdorp M, Romijn JA, Serlie MJ.
Magazine: Metabolism
Auteur: Ter Horst KW, Gilijamse PW, Ackermans MT, Soeters MR, Nieuwdorp M, Romijn JA, Serlie MJ.
Magazine: Metabolism
Titel: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
Auteur: Udayappan, Shanthadevi D., Kovatcheva-Datchary, Petia, Bakker, Guido J., Havik, Stefan R., Herrema, Hilde, Cani, Patrice D., Bouter, Kristien E., Belzer, Clara, Witjes, Julia J., Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H., Aalvink, Steven, Dallinga-Thie, Geesje M., Heilig, Hans G. H. J., Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A., Hoekstra, Joost B. L., Holleman, Frits, Stroes, Erik S. G., Groen, Albert K., Bäckhed, Fredrik, de Vos, Willem M.,
Magazine: PLoS ONE
Auteur: Udayappan, Shanthadevi D., Kovatcheva-Datchary, Petia, Bakker, Guido J., Havik, Stefan R., Herrema, Hilde, Cani, Patrice D., Bouter, Kristien E., Belzer, Clara, Witjes, Julia J., Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H., Aalvink, Steven, Dallinga-Thie, Geesje M., Heilig, Hans G. H. J., Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A., Hoekstra, Joost B. L., Holleman, Frits, Stroes, Erik S. G., Groen, Albert K., Bäckhed, Fredrik, de Vos, Willem M.,
Magazine: PLoS ONE
Titel: In Vivo Imaging of Enhanced Leukocyte Accumulation in Atherosclerotic Lesions in Humans
Auteur: van der Valk, Fleur M., Kroon, Jeffrey, Potters, Wouter V., Thurlings, Rogier M., Bennink, Roelof J., Verberne, Hein J., Nederveen, Aart J., Nieuwdorp, Max, Mulder, Willem J.M., Fayad, Zahi A., van Buul, Jaap D., Stroes, Erik S.G.
Magazine: JACC Cardiovasc Imaging
Auteur: van der Valk, Fleur M., Kroon, Jeffrey, Potters, Wouter V., Thurlings, Rogier M., Bennink, Roelof J., Verberne, Hein J., Nederveen, Aart J., Nieuwdorp, Max, Mulder, Willem J.M., Fayad, Zahi A., van Buul, Jaap D., Stroes, Erik S.G.
Magazine: JACC Cardiovasc Imaging
Titel: High daily insulin exposure in patients with type 2 diabetes is associated with increased risk of cardiovascular events
Auteur: Stoekenbroek, R.M., Rensing, K.L., Bernelot Moens, S.J., Nieuwdorp, M., DeVries, J.H., Zwinderman, A.H., Stroes, E.S., Currie, C.J., Hutten, B.A.
Magazine: Atherosclerosis
Auteur: Stoekenbroek, R.M., Rensing, K.L., Bernelot Moens, S.J., Nieuwdorp, M., DeVries, J.H., Zwinderman, A.H., Stroes, E.S., Currie, C.J., Hutten, B.A.
Magazine: Atherosclerosis
Titel: Gut Microbiota and Energy Expenditure in Health and Obesity
Auteur: Bakker, Guido J., Zhao, Jing, Herrema, Hilde, Nieuwdorp, Max
Magazine: Journal of Clinical Gastroenterology
Auteur: Bakker, Guido J., Zhao, Jing, Herrema, Hilde, Nieuwdorp, Max
Magazine: Journal of Clinical Gastroenterology
Titel: Hepatic Diacylglycerol-Associated Protein Kinase Ce Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.
Auteur: Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.
Magazine: Cell Reports
Auteur: Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.
Magazine: Cell Reports
Titel: Methods for quantifying adipose tissue insulin resistance in overweight/obese humans
Auteur: ter Horst, K W, van Galen, K A, Gilijamse, P W, Hartstra, A V, de Groot, P F, van der Valk, F M, Ackermans, M T, Nieuwdorp, M, Romijn, J A, Serlie, M J
Magazine: International Journal of Obesity
Auteur: ter Horst, K W, van Galen, K A, Gilijamse, P W, Hartstra, A V, de Groot, P F, van der Valk, F M, Ackermans, M T, Nieuwdorp, M, Romijn, J A, Serlie, M J
Magazine: International Journal of Obesity
Titel: Human microbiome as therapeutic intervention target to reduce cardiovascular disease risk.
Auteur: Koopen AM, Groen AK, Nieuwdorp M.
Magazine: Current Opinion in Lipidology
Auteur: Koopen AM, Groen AK, Nieuwdorp M.
Magazine: Current Opinion in Lipidology
Titel: van Beurden YH, Nieuwdorp M, van de Berg PJEJ, Mulder CJJ, Goorhuis A.
Auteur: Current challenges in the treatment of severe Clostridium difficile infection: early treatment potential of fecal microbiota transplantation.
Magazine: Journal of Clinical Gastroenterology
Auteur: Current challenges in the treatment of severe Clostridium difficile infection: early treatment potential of fecal microbiota transplantation.
Magazine: Journal of Clinical Gastroenterology
Titel: Recommendations for Probiotic Use—2015 Update
Auteur: Floch, Martin H., Walker, W. Allan, Sanders, Mary Ellen, Nieuwdorp, Max, Kim, Adam S., Brenner, David A., Qamar, Amir A., Miloh, Tamir A., Guarino, Alfredo, Guslandi, Mario, Dieleman, Levinus A., Ringel, Yehuda, Quigley, Eamonn M.M., Brandt, Lawrence J.
Magazine: Journal of Clinical Gastroenterology
Auteur: Floch, Martin H., Walker, W. Allan, Sanders, Mary Ellen, Nieuwdorp, Max, Kim, Adam S., Brenner, David A., Qamar, Amir A., Miloh, Tamir A., Guarino, Alfredo, Guslandi, Mario, Dieleman, Levinus A., Ringel, Yehuda, Quigley, Eamonn M.M., Brandt, Lawrence J.
Magazine: Journal of Clinical Gastroenterology
Titel: Intestinal Ralstonia pickettii augments glucose intolerance in obesity
Auteur: Udayappan, Shanthadevi D., Kovatcheva-Datchary, Petia, Bakker, Guido J., Havik, Stefan R., Herrema, Hilde, Cani, Patrice D., Bouter, Kristien E., Belzer, Clara, Witjes, Julia J., Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H., Aalvink, Steven, Dallinga-Thie, Geesje M., Heilig, Hans G. H. J., Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A., Hoekstra, Joost B. L., Holleman, Frits, Stroes, Erik S. G., Groen, Albert K., Bäckhed, Fredrik, de Vos, Willem M.,
Magazine: PLoS ONE
Auteur: Udayappan, Shanthadevi D., Kovatcheva-Datchary, Petia, Bakker, Guido J., Havik, Stefan R., Herrema, Hilde, Cani, Patrice D., Bouter, Kristien E., Belzer, Clara, Witjes, Julia J., Vrieze, Anne, de Sonnaville, Noor, Chaplin, Alice, van Raalte, Daniel H., Aalvink, Steven, Dallinga-Thie, Geesje M., Heilig, Hans G. H. J., Bergström, Göran, van der Meij, Suzan, van Wagensveld, Bart A., Hoekstra, Joost B. L., Holleman, Frits, Stroes, Erik S. G., Groen, Albert K., Bäckhed, Fredrik, de Vos, Willem M.,
Magazine: PLoS ONE
Titel:
Microbial modulation of insulin sensitivity.
Auteur: Khan MT, Nieuwdorp M, Bäckhed F.
Magazine: Cell Metabolism
Auteur: Khan MT, Nieuwdorp M, Bäckhed F.
Magazine: Cell Metabolism
Titel: Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance.
Auteur: Surendran RP, Udayyapan SD, Clemente-Postigo M, Havik SR, Schimmel AWM, Tinahones F, Nieuwdorp M, Dallinga-Thie GM.
Magazine: PLoS ONE
Auteur: Surendran RP, Udayyapan SD, Clemente-Postigo M, Havik SR, Schimmel AWM, Tinahones F, Nieuwdorp M, Dallinga-Thie GM.
Magazine: PLoS ONE
Titel: Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans
Auteur: Meijnikman, Abraham S, Gerdes, Victor E, Nieuwdorp, Max, Herrema, Hilde
Magazine: Endocrine Review
Auteur: Meijnikman, Abraham S, Gerdes, Victor E, Nieuwdorp, Max, Herrema, Hilde
Magazine: Endocrine Review
Titel: Fecal microbiota transplantation in metabolic syndrome: History, present and future.
Auteur: de Groot PF, Frissen MN, de Clercq NC, Nieuwdorp M.
Magazine: Gut
Auteur: de Groot PF, Frissen MN, de Clercq NC, Nieuwdorp M.
Magazine: Gut
Titel: Methods for quantifying adipose tissue insulin resistance in overweight/obese humans.
Auteur: Ter Horst KW, van Galen KA, Gilijamse PW, Hartstra AV, de Groot PF, van der Valk FM, Ackermans MT, Nieuwdorp M, Romijn JA, Serlie MJ.
Magazine: International Journal of Obesity
Auteur: Ter Horst KW, van Galen KA, Gilijamse PW, Hartstra AV, de Groot PF, van der Valk FM, Ackermans MT, Nieuwdorp M, Romijn JA, Serlie MJ.
Magazine: International Journal of Obesity
Titel: Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients
Auteur: Emanuel, Anna L., de Clercq, Nicolien C., Koopen, Annefleur M., van Poelgeest, Erik, Serlie, Mireille J. M., van Raalte, Daniel H., Kramer, Mark H. H., Nieuwdorp, Max, Eringa, Etto C., Serné, Erik H.
Magazine: Diabetes, Obesity and Metabolism
Auteur: Emanuel, Anna L., de Clercq, Nicolien C., Koopen, Annefleur M., van Poelgeest, Erik, Serlie, Mireille J. M., van Raalte, Daniel H., Kramer, Mark H. H., Nieuwdorp, Max, Eringa, Etto C., Serné, Erik H.
Magazine: Diabetes, Obesity and Metabolism
Titel: Domain intelligible models.
Auteur: Imangaliyev S, Prodan A, Nieuwdorp M, Groen AK, van Riel NAW, Levin E.
Magazine: Nature Methods
Auteur: Imangaliyev S, Prodan A, Nieuwdorp M, Groen AK, van Riel NAW, Levin E.
Magazine: Nature Methods
Titel: Gut Microbiota and the Gut-Brain Axis: New Insights in the Pathophysiology of Metabolic Syndrome.
Auteur: de Clercq NC, Frissen MN, Groen AK, Nieuwdorp M.
Magazine: Psychosomatic Medicine
Auteur: de Clercq NC, Frissen MN, Groen AK, Nieuwdorp M.
Magazine: Psychosomatic Medicine
Titel: Are Proton Pump Inhibitors Affecting Intestinal Microbiota Health?
Auteur: Melgar, Silvia, Nieuwdorp, Max
Magazine: Gastroenterology
Auteur: Melgar, Silvia, Nieuwdorp, Max
Magazine: Gastroenterology
Titel: Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects
Auteur: Bouter, KEC, Bakker, GJ, Levin, E., Hartstra, AV, Kootte, RS, Udayappan, SD, Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., Stahlman, M., Holleman, F., van Riel, N. A. W., Verberne, HJ, Romijn, JA, Dallinga-Thie, GM, Serlie, MJ, Ackermans, MT, Kemper, EM, Willems van Dijk, K., Backhed, F., Groen, AK, Nieuwdorp, M.
Magazine: Clinical and Translational Science
Auteur: Bouter, KEC, Bakker, GJ, Levin, E., Hartstra, AV, Kootte, RS, Udayappan, SD, Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., Stahlman, M., Holleman, F., van Riel, N. A. W., Verberne, HJ, Romijn, JA, Dallinga-Thie, GM, Serlie, MJ, Ackermans, MT, Kemper, EM, Willems van Dijk, K., Backhed, F., Groen, AK, Nieuwdorp, M.
Magazine: Clinical and Translational Science
Titel: Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes
Auteur: Hartstra, Annick V., Bouter, Kristien E.C., Bäckhed, Fredrik, Nieuwdorp, Max
Magazine: Diabetes Care
Auteur: Hartstra, Annick V., Bouter, Kristien E.C., Bäckhed, Fredrik, Nieuwdorp, Max
Magazine: Diabetes Care
Titel: Potential of butyrate to influence food intake in mice and men
Auteur: Fluitman, Kristina S, Wijdeveld, Madelief, Nieuwdorp, Max, IJzerman, Richard G
Magazine: Gut
Auteur: Fluitman, Kristina S, Wijdeveld, Madelief, Nieuwdorp, Max, IJzerman, Richard G
Magazine: Gut
Titel: Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study.
Auteur: de Groot PF, Belzer C, Aydin Ö, Levin E, Levels JH, Aalvink S, Boot F, Holleman F, van Raalte DH, Scheithauer TP, Simsek S, Schaap FG, Olde Damink SWM, Roep BO, Hoekstra JB, de Vos WM, Nieuwdorp M.
Magazine: PLoS ONE
Auteur: de Groot PF, Belzer C, Aydin Ö, Levin E, Levels JH, Aalvink S, Boot F, Holleman F, van Raalte DH, Scheithauer TP, Simsek S, Schaap FG, Olde Damink SWM, Roep BO, Hoekstra JB, de Vos WM, Nieuwdorp M.
Magazine: PLoS ONE
Titel:
Translating lipid-driven infammation in atherosclerosis
Auteur: Fleur van der Valk
Auteur: Fleur van der Valk
Titel: Gut microbiota in relation to pathogenesis of obesity and type 2 diabetes
Auteur: Shanta Devi Udayappan
Auteur: Shanta Devi Udayappan
Titel:
Functional consequences of inborn and acquired errors in endothelial glycocalyx heparan sulfates
Auteur: Hans Leonard Mooij
Auteur: Hans Leonard Mooij
Titel: Obesity, Ectopic Lipids, and Insulin Resistance. Tissue-Specific Defects in Nutrient Handling
Auteur: Prof. dr. J.A. Romijn prof. dr. M. Nieuwdorp en dr. M.J.M. Serlie.
Auteur: Prof. dr. J.A. Romijn prof. dr. M. Nieuwdorp en dr. M.J.M. Serlie.
Titel:
Fecal Microbiota Transplantation: Clinical and experimental studies
Auteur: Els van Nood
Auteur: Els van Nood
Titel: Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond Clostridium difficile
Auteur: Bakker, Guido J., Nieuwdorp, Max
Auteur: Bakker, Guido J., Nieuwdorp, Max
Verslagen
Samenvatting van de aanvraag
The number of subjects with type 2 diabetes mellitus increases worldwide. Visceral adipose tissue inflammation by macrophages is increasingly recognized as a crucial modulator of the insulin resistance underlying type 2 diabetes. Although many immunological processes have been put forward, the initial trigger that ignites this inflammatory response is still unknown. Pilot data from my group suggest that intestinal Gram-negative bacteria (notably Ralstonia pickettii), in conjunction with increased intestinal permeability and altered gutmicrobiota composition initiate and drive the development of insulin resistance. Insights from human host-microbiota interaction may provide novel perspectives to understand human disease phenotypes, design diagnostics and identify potential therapeutic targets. I aim to decipher which immunological mechanisms regulate intestinal bacterial translocation, how small intestinal microbiota regulate macrophage function in intestinal and visceral adipose tissue, and whether this ultimately results in insulin resistance. Therefore, I will:
WP1. Identify whether Ralstonia pickettii is causally involved in human visceral adipose tissue inflammation and insulin resistance (causality)
WP2. Determine via which deficiency in Toll-like receptor (TLR) functioning Ralstonia pickettii can translocate and induce visceral adipose tissue inflammation and insulin resistance (pathophysiology)
WP3. Establish how therapeutic interventions directed at the immune system (e.g. vaccination) can reverse these processes (therapy)
We will perform detailed postprandial lipid load studies and stable isotope-based glucose-lipid flux studies in combination with fecal transplantation studies in (insulin resistant) subjects scheduled for surgery to identify intestinal microbiota involved in adipose tissue inflammation. These studies will be strengthened by Ralstonia pickettii inoculation experiments in chimeric TLR2/5 knockout insulin resistant mice. The relation between intestinal microbiota and intestinal phagocyte subsets will also be studied in these murine and human models of insulin resistance.
This will allow demonstrating whether Ralstonia pickettii species are causally involved in adipose tissue inflammation and insulin resistance, thus providing a perspective for novel diagnostic and therapeutic targets.