Effective Prediction of Outcome after Congenital Heart Surgery (EPOCH Study)
Projectomschrijving
Het doel van dit project was het verbeteren van de zorg en de kwaliteit van leven van 3.9 miljoen patiënten met een aangeboren hartafwijking in Europa door het ontwikkelen van
betrouwbare methoden waarmee niet alleen de prognose van deze patiënten voorspeld kan worden, maar ook het optimale tijdstip van re-interventie. De resultaten van dit
project hebben ertoe geleid dat we meerdere (nieuwe) specifieke kenmerken van patiënten hebben geïdentificeerd die ons in staat stellen beter te voorspellen wanneer
patiënten met een aangeboren hartafwijking bijvoorbeeld een interventie moeten ondergaan. Deze bevindingen hebben we gebruikt om innovatieve predictie modellen te
bouwen die enerzijds ons in staat stellen om beter de uitkomsten van bepaalde behandelingen te voorspellen en anderzijds aangeven wanneer een eventuele nieuwe
operatie plaats zal moeten vinden. De verwachting is dat deze predictie modellen in de toekomst steeds vaker gebruikt zullen worden bij het nemen van behandel beslissingen
bij patiënten met aangeboren hartafwijkingen.
Producten
Titel: The first EACTS QUIP database results on coronary artery bypass
surgery
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Crucial basic statistics for scientific accuracy
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: The EACTS database: needed to get insights on valvular surgery in
Europe
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: The propensity score: opening a black box. Matching patients and
assessing balance
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Using repeated measurements for echocardiography data
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Propensity-matched analysis: what am I doing?
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Comparing baseline characteristics
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Does pregnancy influence the outcome of patients with a prosthetic
heart valve or homograft?
Auteur: MM Mokhles
Auteur: MM Mokhles
Titel: Long-term clinical outcome and echocardiographic function of homografts in the right ventricular outflow tract†
Auteur: Romeo, Jamie L R, Mokhles, M Mostafa, van de Woestijne, Pieter, de Jong, Peter, van den Bosch, Annemien, van Beynum, Ingrid M, Takkenberg, Johanna J M, Bogers, Ad J J C
Magazine: European Journal of Cardio-Thoracic Surgery
Auteur: Romeo, Jamie L R, Mokhles, M Mostafa, van de Woestijne, Pieter, de Jong, Peter, van den Bosch, Annemien, van Beynum, Ingrid M, Takkenberg, Johanna J M, Bogers, Ad J J C
Magazine: European Journal of Cardio-Thoracic Surgery
Titel: Male-female differences in aortic valve and combined aortic valve/coronary surgery: a national cohort study in the Netherlands
Auteur: Mokhles, M Mostafa, Soloukey Tbalvandany, Sadaf, Siregar, Sabrina, Versteegh, Michel I M, Noyez, Luc, van Putte, Bart, Vonk, Alexander B A, Roos-Hesselink, Jolien W, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: BMJ Open
Auteur: Mokhles, M Mostafa, Soloukey Tbalvandany, Sadaf, Siregar, Sabrina, Versteegh, Michel I M, Noyez, Luc, van Putte, Bart, Vonk, Alexander B A, Roos-Hesselink, Jolien W, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: BMJ Open
Titel: Effectiveness of adherence to a preoperative antiplatelet and anticoagulation cessation protocol in cardiac surgery
Auteur: van Valen, Richard, van Gameren, Menno, Mokhles, Mostafa M, Takkenberg, Johanna J M, ter Horst, Maarten, Hofland, Jan, Bogers, Ad J J C
Magazine: Interact Cardiovasc Thorac Surg
Auteur: van Valen, Richard, van Gameren, Menno, Mokhles, Mostafa M, Takkenberg, Johanna J M, ter Horst, Maarten, Hofland, Jan, Bogers, Ad J J C
Magazine: Interact Cardiovasc Thorac Surg
Titel: Decellularized Versus Standard Pulmonary Allografts in the Ross Procedure: Propensity-Matched Analysis
Auteur: da Costa, Francisco D.A., Etnel, Jonathan R.G., Charitos, Efstratios I., Sievers, Hans-Hinrich, Stierle, Ulrich, Fornazari, Daniele, Takkenberg, Johanna J.M., Bogers, Ad J.J.C., Mokhles, M. Mostafa
Magazine: Annals of Thoracic Surgery
Auteur: da Costa, Francisco D.A., Etnel, Jonathan R.G., Charitos, Efstratios I., Sievers, Hans-Hinrich, Stierle, Ulrich, Fornazari, Daniele, Takkenberg, Johanna J.M., Bogers, Ad J.J.C., Mokhles, M. Mostafa
Magazine: Annals of Thoracic Surgery
Titel: When Cold Matters, Consider Your Options
Auteur: Abjigitova, Djamila, Bogers, Ad J.J.C., Bekkers, Jos A., Mokhles, M. Mostafa
Magazine: Annals of Thoracic Surgery
Auteur: Abjigitova, Djamila, Bogers, Ad J.J.C., Bekkers, Jos A., Mokhles, M. Mostafa
Magazine: Annals of Thoracic Surgery
Titel: Statistical primer: how to deal with missing data in scientific research?†
Auteur: Papageorgiou, Grigorios, Grant, Stuart W, Takkenberg, Johanna J M, Mokhles, Mostafa M
Magazine: Interact Cardiovasc Thorac Surg
Auteur: Papageorgiou, Grigorios, Grant, Stuart W, Takkenberg, Johanna J M, Mokhles, Mostafa M
Magazine: Interact Cardiovasc Thorac Surg
Titel: Letter by Romeo et al Regarding Article, “Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study”
Auteur: Romeo, Jamie L.R., Bogers, Ad J.J.C., Mokhles, Mostafa M.
Magazine: Circulation
Auteur: Romeo, Jamie L.R., Bogers, Ad J.J.C., Mokhles, Mostafa M.
Magazine: Circulation
Titel: Male–female differences in characteristics and early outcomes of patients undergoing tricuspid valve surgery: a national cohort study in the Netherlands
Auteur: Veen, Kevin M, Mokhles, Mostafa M, Braun, Jerry, Versteegh, Michel I M, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: European Journal of Cardio-Thoracic Surgery
Auteur: Veen, Kevin M, Mokhles, Mostafa M, Braun, Jerry, Versteegh, Michel I M, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: European Journal of Cardio-Thoracic Surgery
Titel: Downsized cryopreserved and standard-sized allografts for right ventricular outflow tract reconstruction in children: long-term single-institutional experience
Auteur: Romeo, Jamie L R, Papageorgiou, Grigorios, van de Woestijne, Pieter C, Takkenberg, Johanna J M, Westenberg, Lauren E H, van Beynum, Ingrid, Bogers, Ad J J C, Mokhles, Mostafa M
Magazine: Interact Cardiovasc Thorac Surg
Auteur: Romeo, Jamie L R, Papageorgiou, Grigorios, van de Woestijne, Pieter C, Takkenberg, Johanna J M, Westenberg, Lauren E H, van Beynum, Ingrid, Bogers, Ad J J C, Mokhles, Mostafa M
Magazine: Interact Cardiovasc Thorac Surg
Titel: Comparison of clinical outcome of stage I non-small cell lung cancer treated surgically or with stereotactic radiotherapy: Results from propensity score analysis
Auteur: Mokhles, Sahar, Verstegen, Naomi, Maat, Alex P.W.M., Birim, Özcan, Bogers, Ad J.J.C., Mokhles, M. Mostafa, Lagerwaard, Frank J., Senan, Suresh, Takkenberg, Johanna J.M.
Magazine: Lung Cancer
Auteur: Mokhles, Sahar, Verstegen, Naomi, Maat, Alex P.W.M., Birim, Özcan, Bogers, Ad J.J.C., Mokhles, M. Mostafa, Lagerwaard, Frank J., Senan, Suresh, Takkenberg, Johanna J.M.
Magazine: Lung Cancer
Titel: Prosthetic valve endocarditis due toPropionibacterium acnes
Auteur: van Valen, Richard, de Lind van Wijngaarden, Robert A.F., Verkaik, Nelianne J., Mokhles, Mostafa M., Bogers, Ad J.J.C.
Magazine: Interact Cardiovasc Thorac Surg
Auteur: van Valen, Richard, de Lind van Wijngaarden, Robert A.F., Verkaik, Nelianne J., Mokhles, Mostafa M., Bogers, Ad J.J.C.
Magazine: Interact Cardiovasc Thorac Surg
Titel: Reply by the Authors of the Original Article
Auteur: Kik, Charles, Mokhles, Mostafa, Bogers, Ad, van Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Auteur: Kik, Charles, Mokhles, Mostafa, Bogers, Ad, van Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Titel: Atrioesophageal Fistula after Minimally Invasive Video-Assisted Epicardial Ablation for Lone Atrial Fibrillation
Auteur: Kik, Charles, Mokhles, Mostafa, Bekkers, Jos, Bogers, Ad, van Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Auteur: Kik, Charles, Mokhles, Mostafa, Bekkers, Jos, Bogers, Ad, van Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Titel: Reconstructive surgery for Ebstein anomaly: three decades of experience
Auteur: Veen, Kevin M, Mokhles, Mostafa M, Roos-Hesselink, Jolien W, Rebel, Bas R, Takkenberg, Johanna J M, Bogers, Ad J J C
Magazine: European Journal of Cardio-Thoracic Surgery
Auteur: Veen, Kevin M, Mokhles, Mostafa M, Roos-Hesselink, Jolien W, Rebel, Bas R, Takkenberg, Johanna J M, Bogers, Ad J J C
Magazine: European Journal of Cardio-Thoracic Surgery
Titel: Reply by the Authors of the Original Article
Auteur: Kik, Charles, Mokhles, Mostafa, Bogers, Ad, Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Auteur: Kik, Charles, Mokhles, Mostafa, Bogers, Ad, Valen, Richard
Magazine: Thoracic and Cardiovascular Surgery
Titel: Mechanical aortic valve replacement in non-elderly adults: meta-analysis and microsimulation
Auteur: Korteland, Nelleke M, Etnel, Jonathan R G, Arabkhani, Bardia, Mokhles, M Mostafa, Mohamad, Arezo, Roos-Hesselink, Jolien W, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: European Heart Journal
Auteur: Korteland, Nelleke M, Etnel, Jonathan R G, Arabkhani, Bardia, Mokhles, M Mostafa, Mohamad, Arezo, Roos-Hesselink, Jolien W, Bogers, Ad J J C, Takkenberg, Johanna J M
Magazine: European Heart Journal
Titel: The Ross Procedure: A Systematic Review, Meta-Analysis, and Microsimulation
Auteur: Etnel, Jonathan R.G., Grashuis, Pepijn, Huygens, Simone A., Pekbay, Begüm, Papageorgiou, Grigorios, Helbing, Willem A., Roos-Hesselink, Jolien W., Bogers, Ad J.J.C., Mokhles, M. Mostafa, Takkenberg, Johanna J.M.
Magazine: Circulation: Cardiovascular Quality and Outcomes
Auteur: Etnel, Jonathan R.G., Grashuis, Pepijn, Huygens, Simone A., Pekbay, Begüm, Papageorgiou, Grigorios, Helbing, Willem A., Roos-Hesselink, Jolien W., Bogers, Ad J.J.C., Mokhles, M. Mostafa, Takkenberg, Johanna J.M.
Magazine: Circulation: Cardiovascular Quality and Outcomes
Titel: Male–female differences and survival in patients undergoing isolated mitral valve surgery: a nationwide cohort study in the Netherlands
Auteur: Mokhles, Mostafa M., Siregar, Sabrina, Versteegh, Michel I.M., Noyez, Luc, van Putte, Bart, Vonk, Alexander B.A., Roos-Hesselink, Jolien W., Bogers, Ad J.J.C., Takkenberg, Johanna J.M.
Magazine: European Journal of Cardio-Thoracic Surgery
Auteur: Mokhles, Mostafa M., Siregar, Sabrina, Versteegh, Michel I.M., Noyez, Luc, van Putte, Bart, Vonk, Alexander B.A., Roos-Hesselink, Jolien W., Bogers, Ad J.J.C., Takkenberg, Johanna J.M.
Magazine: European Journal of Cardio-Thoracic Surgery
Titel: Outcomes of Pregnancy After Right Ventricular Outflow Tract Reconstruction With an Allograft Conduit
Auteur: Romeo, Jamie L.R., Takkenberg, Johanna J.M., Roos-Hesselink, Jolien W., Hanif, Milad, Cornette, Jerome M.J., van Leeuwen, Wouter J., van Dijk, Arie, Bogers, Ad J.J.C., Mokhles, M. Mostafa
Magazine: Journal of the American College of Cardiology
Auteur: Romeo, Jamie L.R., Takkenberg, Johanna J.M., Roos-Hesselink, Jolien W., Hanif, Milad, Cornette, Jerome M.J., van Leeuwen, Wouter J., van Dijk, Arie, Bogers, Ad J.J.C., Mokhles, M. Mostafa
Magazine: Journal of the American College of Cardiology
Titel: Exercise and sports participation in patients with thoracic aortic disease: a review
Auteur: Thijssen, Carlijn G. E., Bons, Lidia R., Gökalp, Arjen L., Van Kimmenade, Roland R. J., Mokhles, Mostafa M., Pelliccia, Antonio, Takkenberg, Johanna J. M., Roos-Hesselink, Jolien W.
Magazine: Expert Review of Cardiovascular Therapy
Auteur: Thijssen, Carlijn G. E., Bons, Lidia R., Gökalp, Arjen L., Van Kimmenade, Roland R. J., Mokhles, Mostafa M., Pelliccia, Antonio, Takkenberg, Johanna J. M., Roos-Hesselink, Jolien W.
Magazine: Expert Review of Cardiovascular Therapy
Titel: The right time-dependent statistics: this is the moment
Auteur: Romeo, Jamie L R, Papageorgiou, Grigorios, Takkenberg, Johanna J M, Mokhles, M Mostafa
Magazine: European Journal of Cardio-Thoracic Surgery
Auteur: Romeo, Jamie L R, Papageorgiou, Grigorios, Takkenberg, Johanna J M, Mokhles, M Mostafa
Magazine: European Journal of Cardio-Thoracic Surgery
Verslagen
Samenvatting van de aanvraag
Advances in cardiology and cardio-thoracic surgery during the past decades have significantly increased life expectancy of patients with congenital heart disease (CHD). At present it is estimated that there are between 1.9 and 3.9 million patients with CHD in Europe and this number is increasing at a rate of 5% per year.
Unfortunately, patients with CHD often require several heart operations during their life. In order to reduce the number of reoperations to a minimum, while maximizing life expectancy, accurate risk prediction models are needed to assess the most optimal timing of reoperation. Delaying a reoperation can damage the heart irreversibly while operating too early can result in more surgeries during patient’s life than strictly necessary leading to reduced life expectancy.
Current risk prediction models are not suitable for adequately predicting the outcome of patients with CHD after cardiac surgery at an individual level and, therefore, cannot be used to assess the most optimal timing of reoperation. This is because of two reasons. Current models do not adequately correlate clinical data of patients with their observed outcome and once built they are not updated regularly.
The two key innovations of this project are development of ‘joint models’ that combine clinical data which are repeatedly collected during follow-up of patients (e.g. biomarkers, echocardiographic data) with patients’ outcome (e.g. valve failure, reoperation, death) and making these models dynamic which means that the model will be updated periodically and therefore will account for changes in patient population and treatment options over time.
Through these novel accurate and dynamic risk prediction models, treatment selection will be optimized and the burden of CHD minimized. This project will serve as a test case for other chronic diseases (cardiac and non-cardiac) where reliable prediction models are urgently needed.