Systems and functional genomics strategies to identify novel vulnerability genes for heart failure
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Titel: A Genome-Wide Association Study of Circulating
Galectin-3
Auteur: Rudolf A. de Boer, Niek Verweij, Dirk J. van Veldhuisen, Harm-Jan Westra, Stephan J. L. Bakker, Ron T. Gansevoort, Anneke C. Muller Kobold, Wiek H. van Gilst, Lude Franke, Irene Mateo Leach, Pim van der Harst
Magazine: PlosOne
Auteur: Rudolf A. de Boer, Niek Verweij, Dirk J. van Veldhuisen, Harm-Jan Westra, Stephan J. L. Bakker, Ron T. Gansevoort, Anneke C. Muller Kobold, Wiek H. van Gilst, Lude Franke, Irene Mateo Leach, Pim van der Harst
Magazine: PlosOne
Titel: Clinical Risk Stratification Optimizes Value of Biomarkers to Predict New-Onset Heart Failure in a Community-Based Cohort
Auteur: Brouwers, F. P., van Gilst, W. H., Damman, K., van den Berg, M. P., Gansevoort, R. T., Bakker, S. J. L., Hillege, H. L., van Veldhuisen, D. J., van der Harst, P., de Boer, R. A.
Magazine: Circulation Heart failure
Auteur: Brouwers, F. P., van Gilst, W. H., Damman, K., van den Berg, M. P., Gansevoort, R. T., Bakker, S. J. L., Hillege, H. L., van Veldhuisen, D. J., van der Harst, P., de Boer, R. A.
Magazine: Circulation Heart failure
Titel: Defining the role of common variation in the genomic and biological architecture of adult human height
Auteur: Andrew R Wood, Tonu Esko, ... Peter MVisscher, Joel NHirschhorn, & Timothy MFrayling
Magazine: Nature Genetics
Auteur: Andrew R Wood, Tonu Esko, ... Peter MVisscher, Joel NHirschhorn, & Timothy MFrayling
Magazine: Nature Genetics
Titel: Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels
Auteur: van Leeuwen, Elisabeth M., Karssen, Lennart C., Deelen, Joris, Isaacs, Aaron, Medina-Gomez, Carolina, Mbarek, Hamdi, Kanterakis, Alexandros, Trompet, Stella, Postmus, Iris, Verweij, Niek, van Enckevort, David J., Huffman, Jennifer E., White, Charles C., Feitosa, Mary F., Bartz, Traci M., Manichaikul, Ani, Joshi, Peter K., Peloso, Gina M., Deelen, Patrick, van Dijk, Freerk, Willemsen, Gonneke, de Geus, Eco J., Milaneschi, Yuri, Penninx, Brenda W.J.H., Francioli, Laurent C., Menelaou, Androniki, P
Magazine: Nature Communications
Auteur: van Leeuwen, Elisabeth M., Karssen, Lennart C., Deelen, Joris, Isaacs, Aaron, Medina-Gomez, Carolina, Mbarek, Hamdi, Kanterakis, Alexandros, Trompet, Stella, Postmus, Iris, Verweij, Niek, van Enckevort, David J., Huffman, Jennifer E., White, Charles C., Feitosa, Mary F., Bartz, Traci M., Manichaikul, Ani, Joshi, Peter K., Peloso, Gina M., Deelen, Patrick, van Dijk, Freerk, Willemsen, Gonneke, de Geus, Eco J., Milaneschi, Yuri, Penninx, Brenda W.J.H., Francioli, Laurent C., Menelaou, Androniki, P
Magazine: Nature Communications
Titel: Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
Auteur: Zimmermann, E., Ängquist, L. H., Mirza, S. S., Zhao, J. H., Chasman, D. I., Fischer, K., Qi, Q., Smith, A. V., Thinggaard, M., Jarczok, M. N., Nalls, M. A., Trompet, S., Timpson, N. J., Schmidt, B., Jackson, A. U., Lyytikäinen, L. P., Verweij, N., Mueller-Nurasyid, M., Vikström, M., Marques-Vidal, P., Wong, A., Meidtner, K., Middelberg, R. P., Strawbridge, R. J., Christiansen, L., Kyvik, K. O., Hamsten, A., Jääskeläinen, T., Tjønneland, A., Eriksson, J. G., Whitfield, J. B., Boeing, H., H
Magazine: Obesity Reviews
Auteur: Zimmermann, E., Ängquist, L. H., Mirza, S. S., Zhao, J. H., Chasman, D. I., Fischer, K., Qi, Q., Smith, A. V., Thinggaard, M., Jarczok, M. N., Nalls, M. A., Trompet, S., Timpson, N. J., Schmidt, B., Jackson, A. U., Lyytikäinen, L. P., Verweij, N., Mueller-Nurasyid, M., Vikström, M., Marques-Vidal, P., Wong, A., Meidtner, K., Middelberg, R. P., Strawbridge, R. J., Christiansen, L., Kyvik, K. O., Hamsten, A., Jääskeläinen, T., Tjønneland, A., Eriksson, J. G., Whitfield, J. B., Boeing, H., H
Magazine: Obesity Reviews
Titel: Genetic Determinants of P Wave Duration and PR Segment
Auteur: Verweij N, Mateo Leach I, van den Boogaard M, van Veldhuisen DJ, Christoffels VM; LifeLines Cohort Study, Hillege HL, van Gilst WH, Barnett P, de Boer RA, van der Harst P.
Magazine: Circulation Cardiovascular Genetics
Auteur: Verweij N, Mateo Leach I, van den Boogaard M, van Veldhuisen DJ, Christoffels VM; LifeLines Cohort Study, Hillege HL, van Gilst WH, Barnett P, de Boer RA, van der Harst P.
Magazine: Circulation Cardiovascular Genetics
Titel: Clinical Risk Stratification Optimizes Value of Biomarkers to Predict New Onset Heart Failure in a Community-Based Cohort
Auteur: Brouwers FP, van Gilst WH, Damman K, van den Berg MP, Gansevoort RT, Bakker SJ, Hillege HL, van Veldhuisen DJ, van der Harst P, de Boer RA.
Magazine: Circulation Heart failure
Auteur: Brouwers FP, van Gilst WH, Damman K, van den Berg MP, Gansevoort RT, Bakker SJ, Hillege HL, van Veldhuisen DJ, van der Harst P, de Boer RA.
Magazine: Circulation Heart failure
Titel: Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
Auteur: Holmes MV, Dale CE, Zuccolo L, ... Palmer TM, Reiner AP, Keating BJ, Dudbridge F, Casas JP; InterAct Consortium.
Magazine: BMJ
Auteur: Holmes MV, Dale CE, Zuccolo L, ... Palmer TM, Reiner AP, Keating BJ, Dudbridge F, Casas JP; InterAct Consortium.
Magazine: BMJ
Titel: Novel loci affecting iron homeostasis and their
effects in individuals at risk for hemochromatosis
Auteur: Beben Benyamin, Tonu Esko, ... Dorine W. Swinkels & John B. Whitfield
Magazine: Nature Communications
Auteur: Beben Benyamin, Tonu Esko, ... Dorine W. Swinkels & John B. Whitfield
Magazine: Nature Communications
Titel: Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin
Auteur: Galesloot, Tessel E., Verweij, Niek, Traglia, Michela, Barbieri, Caterina, van Dijk, Freerk, Geurts-Moespot, Anneke J., Girelli, Domenico, Kiemeney, Lambertus A. L. M., Sweep, Fred C. G. J., Swertz, Morris A., van der Meer, Peter, Camaschella, Clara, Toniolo, Daniela, Vermeulen, Sita H., van der Harst, Pim, Swinkels, Dorine W.
Magazine: PLoS ONE
Auteur: Galesloot, Tessel E., Verweij, Niek, Traglia, Michela, Barbieri, Caterina, van Dijk, Freerk, Geurts-Moespot, Anneke J., Girelli, Domenico, Kiemeney, Lambertus A. L. M., Sweep, Fred C. G. J., Swertz, Morris A., van der Meer, Peter, Camaschella, Clara, Toniolo, Daniela, Vermeulen, Sita H., van der Harst, Pim, Swinkels, Dorine W.
Magazine: PLoS ONE
Titel: Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram
Auteur: Verweij, Niek, Mateo Leach, Irene, Isaacs, Aaron, Arking, Dan E., Bis, Joshua C., Pers, Tune H., Van Den Berg, Marten E., Lyytikäinen, Leo-Pekka, Barnett, Phil, Wang, Xinchen, Soliman, Elsayed Z., Van Duijn, Cornelia M., Kähönen, Mika, Van Veldhuisen, Dirk J., Kors, Jan A., Raitakari, Olli T., Silva, Claudia T., Lehtimäki, Terho, Hillege, Hans L., Hirschhorn, Joel N., Boyer, Laurie A., Van Gilst, Wiek H., Alonso, Alvaro, Sotoodehnia, Nona, Eijgelsheim, Mark, De Boer, Rudolf A., De Bakker, Pa
Magazine: Human Molecular Genetics
Link: http://hmg.oxfordjournals.org/content/25/10/2093.full.pdf
Auteur: Verweij, Niek, Mateo Leach, Irene, Isaacs, Aaron, Arking, Dan E., Bis, Joshua C., Pers, Tune H., Van Den Berg, Marten E., Lyytikäinen, Leo-Pekka, Barnett, Phil, Wang, Xinchen, Soliman, Elsayed Z., Van Duijn, Cornelia M., Kähönen, Mika, Van Veldhuisen, Dirk J., Kors, Jan A., Raitakari, Olli T., Silva, Claudia T., Lehtimäki, Terho, Hillege, Hans L., Hirschhorn, Joel N., Boyer, Laurie A., Van Gilst, Wiek H., Alonso, Alvaro, Sotoodehnia, Nona, Eijgelsheim, Mark, De Boer, Rudolf A., De Bakker, Pa
Magazine: Human Molecular Genetics
Link: http://hmg.oxfordjournals.org/content/25/10/2093.full.pdf
Titel: Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
Auteur: Teumer, Alexander, Tin, Adrienne, Sorice, Rossella, Gorski, Mathias, Yeo, Nan Cher, Chu, Audrey Y., Li, Man, Li, Yong, Mijatovic, Vladan, Ko, Yi-An, Taliun, Daniel, Luciani, Alessandro, Chen, Ming-Huei, Yang, Qiong, Foster, Meredith C., Olden, Matthias, Hiraki, Linda T., Tayo, Bamidele O., Fuchsberger, Christian, Dieffenbach, Aida Karina, Shuldiner, Alan R., Smith, Albert V., Zappa, Allison M., Lupo, Antonio, Kollerits, Barbara, Ponte, Belen, Stengel, Bénédicte, Krämer, Bernhard K., Paulweber
Magazine: Diabetes
Auteur: Teumer, Alexander, Tin, Adrienne, Sorice, Rossella, Gorski, Mathias, Yeo, Nan Cher, Chu, Audrey Y., Li, Man, Li, Yong, Mijatovic, Vladan, Ko, Yi-An, Taliun, Daniel, Luciani, Alessandro, Chen, Ming-Huei, Yang, Qiong, Foster, Meredith C., Olden, Matthias, Hiraki, Linda T., Tayo, Bamidele O., Fuchsberger, Christian, Dieffenbach, Aida Karina, Shuldiner, Alan R., Smith, Albert V., Zappa, Allison M., Lupo, Antonio, Kollerits, Barbara, Ponte, Belen, Stengel, Bénédicte, Krämer, Bernhard K., Paulweber
Magazine: Diabetes
Titel: Gene-gene Interaction Analyses for Atrial Fibrillation
Auteur: Honghuang Lin, Martina Mueller-Nurasyid, Albert V. Smith, Dan E. Arking, John Barnard, Traci M. Bartz, Kathryn L. Lunetta, Kurt Lohman, Marcus E. Kleber, Steven A. Lubitz, Bastiaan Geelhoed, Stella Trompet, Maartje N. Niemeijer, Tim Kacprowski, Daniel I. Chasman, Derek Klarin, Moritz F. Sinner, Melanie Waldenberger, Thomas Meitinger, Tamara B. Harris, Lenore J. Launer, Elsayed Z. Soliman, Lin Y. Chen, Jonathan D. Smith, David R. Van Wagoner, Jerome I. Rotter, Bruce M. Psaty, Zhijun Xie, Audrey E
Magazine: Scientific Reports
Auteur: Honghuang Lin, Martina Mueller-Nurasyid, Albert V. Smith, Dan E. Arking, John Barnard, Traci M. Bartz, Kathryn L. Lunetta, Kurt Lohman, Marcus E. Kleber, Steven A. Lubitz, Bastiaan Geelhoed, Stella Trompet, Maartje N. Niemeijer, Tim Kacprowski, Daniel I. Chasman, Derek Klarin, Moritz F. Sinner, Melanie Waldenberger, Thomas Meitinger, Tamara B. Harris, Lenore J. Launer, Elsayed Z. Soliman, Lin Y. Chen, Jonathan D. Smith, David R. Van Wagoner, Jerome I. Rotter, Bruce M. Psaty, Zhijun Xie, Audrey E
Magazine: Scientific Reports
Titel: 52 Genetic Loci Influencing Myocardial Mass
Auteur: van der Harst, Pim, van Setten, Jessica, Verweij, Niek, Vogler, Georg, Franke, Lude, Maurano, Matthew T., Wang, Xinchen, Mateo Leach, Irene, Eijgelsheim, Mark, Sotoodehnia, Nona, Hayward, Caroline, Sorice, Rossella, Meirelles, Osorio, Lyytikäinen, Leo-Pekka, Polašek, Ozren, Tanaka, Toshiko, Arking, Dan E., Ulivi, Sheila, Trompet, Stella, Müller-Nurasyid, Martina, Smith, Albert V., Dörr, Marcus, Kerr, Kathleen F., Magnani, Jared W., Del Greco M., Fabiola, Zhang, Weihua, Nolte, Ilja M., Silva,
Magazine: Journal of the American College of Cardiology
Link: http://www.sciencedirect.com/science/article/pii/S0735109716346642
Auteur: van der Harst, Pim, van Setten, Jessica, Verweij, Niek, Vogler, Georg, Franke, Lude, Maurano, Matthew T., Wang, Xinchen, Mateo Leach, Irene, Eijgelsheim, Mark, Sotoodehnia, Nona, Hayward, Caroline, Sorice, Rossella, Meirelles, Osorio, Lyytikäinen, Leo-Pekka, Polašek, Ozren, Tanaka, Toshiko, Arking, Dan E., Ulivi, Sheila, Trompet, Stella, Müller-Nurasyid, Martina, Smith, Albert V., Dörr, Marcus, Kerr, Kathleen F., Magnani, Jared W., Del Greco M., Fabiola, Zhang, Weihua, Nolte, Ilja M., Silva,
Magazine: Journal of the American College of Cardiology
Link: http://www.sciencedirect.com/science/article/pii/S0735109716346642
Titel: Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality
Auteur: Eppinga, Ruben N, Hagemeijer, Yanick, Burgess, Stephen, Hinds, David A, Stefansson, Kari, Gudbjartsson, Daniel F, van Veldhuisen, Dirk J, Munroe, Patricia B, Verweij, Niek, van der Harst, Pim
Magazine: Nature Genetics
Link: http://www.nature.com/ng/journal/vaop/ncurrent/pdf/ng.3708.pdf
Auteur: Eppinga, Ruben N, Hagemeijer, Yanick, Burgess, Stephen, Hinds, David A, Stefansson, Kari, Gudbjartsson, Daniel F, van Veldhuisen, Dirk J, Munroe, Patricia B, Verweij, Niek, van der Harst, Pim
Magazine: Nature Genetics
Link: http://www.nature.com/ng/journal/vaop/ncurrent/pdf/ng.3708.pdf
Titel: Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion
Auteur: Hartman, Minke H. T., Vreeswijk-Baudoin, Inge, Groot, Hilde E., van de Kolk, Kees W. A., de Boer, Rudolf A., Mateo Leach, Irene, Vliegenthart, Rozemarijn, Sillje, Herman H. W., van der Harst, Pim
Magazine: PLoS ONE
Auteur: Hartman, Minke H. T., Vreeswijk-Baudoin, Inge, Groot, Hilde E., van de Kolk, Kees W. A., de Boer, Rudolf A., Mateo Leach, Irene, Vliegenthart, Rozemarijn, Sillje, Herman H. W., van der Harst, Pim
Magazine: PLoS ONE
Titel: KLBis associated with alcohol drinking, and its gene product ß-Klotho is necessary for FGF21 regulation of alcohol preference
Auteur: Schumann, Gunter, Liu, Chunyu, O’Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Segura Lepe, Marcelo, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hällfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Åsa, Joshi, Peter K., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu, Luan, Jian’an, Lyyt
Magazine: Proceedings of the National Academy of Sciences USA
Auteur: Schumann, Gunter, Liu, Chunyu, O’Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Segura Lepe, Marcelo, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hällfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Åsa, Joshi, Peter K., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu, Luan, Jian’an, Lyyt
Magazine: Proceedings of the National Academy of Sciences USA
Titel: Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
Auteur: Holmes, M. V., Dale, C. E., Zuccolo, L., Silverwood, R. J., Guo, Y., Ye, Z., Prieto-Merino, D., Dehghan, A., Trompet, S., Wong, A., Cavadino, A., Drogan, D., Padmanabhan, S., Li, S., Yesupriya, A., Leusink, M., Sundstrom, J., Hubacek, J. A., Pikhart, H., Swerdlow, D. I., Panayiotou, A. G., Borinskaya, S. A., Finan, C., Shah, S., Kuchenbaecker, K. B., Shah, T., Engmann, J., Folkersen, L., Eriksson, P., Ricceri, F., Melander, O., Sacerdote, C., Gamble, D. M., Rayaprolu, S., Ross, O. A., McLachlan,
Magazine: BMJ
Auteur: Holmes, M. V., Dale, C. E., Zuccolo, L., Silverwood, R. J., Guo, Y., Ye, Z., Prieto-Merino, D., Dehghan, A., Trompet, S., Wong, A., Cavadino, A., Drogan, D., Padmanabhan, S., Li, S., Yesupriya, A., Leusink, M., Sundstrom, J., Hubacek, J. A., Pikhart, H., Swerdlow, D. I., Panayiotou, A. G., Borinskaya, S. A., Finan, C., Shah, S., Kuchenbaecker, K. B., Shah, T., Engmann, J., Folkersen, L., Eriksson, P., Ricceri, F., Melander, O., Sacerdote, C., Gamble, D. M., Rayaprolu, S., Ross, O. A., McLachlan,
Magazine: BMJ