TissueFAXS: the equivalent to flow cytometry for multiparameter quantitative analyses in tissues
Projectomschrijving
Aan de ontwikkeling van ziekten (bijvoorbeeld atherosclerose, autoimmuunziekten en kanker) ligt vaak een verstoorde functie van cellen ten grondslag. Eiwitten spelen een belangrijke rol bij de functie van cellen en veranderingen in productie van eiwitten is dan ook vaak betrokken bij de ziekte ontwikkeling. Het is daarom van groot belang in staat te zijn te weten welke, en hoeveel eiwitten gemaakt worden door de verschillende cellen in het weefsel tijdens de ontwikkeling van een ziekte. In dit project wordt een geavanceerde microscoop gebruikt die ons in staat stelt de aanwezigheid en hoeveelheid van verschillende eiwitten in gezonde en zieke weefsels te meten. Op deze manier wordt er nieuwe informatie verkregen over welke eiwitten betrokken zijn bij het niet goed functioneren van cellen, wat belangrijk is voor de ontwikkeling van nieuwe therapieën om ziekten te voorkomen of te behandelen.
Producten
Titel: Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of -Tubulin Proteostasis in Experimental and Human Atrial Fibrillation
Auteur: Zhang, D., Wu, C.-T., Qi, X., Meijering, R. A. M., Hoogstra-Berends, F., Tadevosyan, A., Cubukcuoglu Deniz, G., Durdu, S., Akar, A. R., Sibon, O. C. M., Nattel, S., Henning, R. H., Brundel, B. J. J. M.
Magazine: Circulation
Auteur: Zhang, D., Wu, C.-T., Qi, X., Meijering, R. A. M., Hoogstra-Berends, F., Tadevosyan, A., Cubukcuoglu Deniz, G., Durdu, S., Akar, A. R., Sibon, O. C. M., Nattel, S., Henning, R. H., Brundel, B. J. J. M.
Magazine: Circulation
Titel: Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction
Auteur: Koopmans, Tim, Kumawat, Kuldeep, Halayko, Andrew J, Gosens, Reinoud
Magazine: Scientific Reports
Auteur: Koopmans, Tim, Kumawat, Kuldeep, Halayko, Andrew J, Gosens, Reinoud
Magazine: Scientific Reports
Titel: VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression
Auteur: Leus, Niek G.J., Morselt, Henriëtte W.M., Zwiers, Peter J., Kowalski, Piotr S., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.
Magazine: International Journal of Pharmaceutics
Auteur: Leus, Niek G.J., Morselt, Henriëtte W.M., Zwiers, Peter J., Kowalski, Piotr S., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.
Magazine: International Journal of Pharmaceutics
Titel: The I?B kinase inhibitor ACHP strongly attenuates TGFß1-induced myofibroblast formation and collagen synthesis
Auteur: Mia, Masum M., Bank, Ruud A.
Magazine: Journal of Cellular and Molecular Medicine
Auteur: Mia, Masum M., Bank, Ruud A.
Magazine: Journal of Cellular and Molecular Medicine
Titel: Priming of microglia in a DNA-repair deficient model of accelerated aging
Auteur: Raj, Divya D.A., Jaarsma, Dick, Holtman, Inge R., Olah, Marta, Ferreira, Filipa M., Schaafsma, Wandert, Brouwer, Nieske, Meijer, Michel M., de Waard, Monique C., van der Pluijm, Ingrid, Brandt, Renata, Kreft, Karim L., Laman, Jon D., de Haan, Gerald, Biber, Knut P.H., Hoeijmakers, Jan H.J., Eggen, Bart J.L., Boddeke, Hendrikus W.G.M.
Magazine: Neurobiology of Aging
Auteur: Raj, Divya D.A., Jaarsma, Dick, Holtman, Inge R., Olah, Marta, Ferreira, Filipa M., Schaafsma, Wandert, Brouwer, Nieske, Meijer, Michel M., de Waard, Monique C., van der Pluijm, Ingrid, Brandt, Renata, Kreft, Karim L., Laman, Jon D., de Haan, Gerald, Biber, Knut P.H., Hoeijmakers, Jan H.J., Eggen, Bart J.L., Boddeke, Hendrikus W.G.M.
Magazine: Neurobiology of Aging
Titel: Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue
Auteur: Mencke, Rik, Harms, Geert, Mirkovic, Katarina, Struik, Joyce, Van Ark, Joris, Van Loon, Ellen, Verkaik, Melissa, De Borst, Martin H., Zeebregts, Clark J., Hoenderop, Joost G., Vervloet, Marc G., Hillebrands, Jan-Luuk
Magazine: Cardiovascular Research
Auteur: Mencke, Rik, Harms, Geert, Mirkovic, Katarina, Struik, Joyce, Van Ark, Joris, Van Loon, Ellen, Verkaik, Melissa, De Borst, Martin H., Zeebregts, Clark J., Hoenderop, Joost G., Vervloet, Marc G., Hillebrands, Jan-Luuk
Magazine: Cardiovascular Research
Titel: RTEL1 contributes to DNA replication and repair and telomere maintenance
Auteur: Uringa EJ, Lisaingo K, Pickett HA, Brind'Amour J, Rohde JH, Zelensky A, Essers J, Lansdorp PM
Magazine: Molecular Biology of the Cell
Auteur: Uringa EJ, Lisaingo K, Pickett HA, Brind'Amour J, Rohde JH, Zelensky A, Essers J, Lansdorp PM
Magazine: Molecular Biology of the Cell
Titel: Adipose stromal cells primed with hypoxia and
inflammation enhance cardiomyocyte
proliferation rate in vitro through STAT3
and Erk1/2
Auteur: Ewa Przybyt, Guido Krenning, Marja GL Brinker and Martin C Harmsen
Magazine: Journal of Translational Medicine
Auteur: Ewa Przybyt, Guido Krenning, Marja GL Brinker and Martin C Harmsen
Magazine: Journal of Translational Medicine
Titel: MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains
Auteur: Bijlard, Marjolein, de Jonge, Jenny C., Klunder, Bert, Nomden, Anita, Hoekstra, Dick, Baron, Wia
Magazine: PLoS ONE
Auteur: Bijlard, Marjolein, de Jonge, Jenny C., Klunder, Bert, Nomden, Anita, Hoekstra, Dick, Baron, Wia
Magazine: PLoS ONE
Titel: Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal
Auteur: Wang, Cuifeng, de Jong, Edwin, Sjollema, Klaas A., Zuhorn, Inge S.
Magazine: Scientific Reports
Auteur: Wang, Cuifeng, de Jong, Edwin, Sjollema, Klaas A., Zuhorn, Inge S.
Magazine: Scientific Reports
Titel: Macrophage phenotypes in the collagen-induced foreign body reaction in rats
Auteur: Sander M. van Putten, Diana T.A. Ploeger, Eliane R. Popa, Ruud A. Bank
Magazine: Acta Biomaterialia
Auteur: Sander M. van Putten, Diana T.A. Ploeger, Eliane R. Popa, Ruud A. Bank
Magazine: Acta Biomaterialia
Titel: In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain
Auteur: Tigchelaar, Wardit, De Jong, Anne Margreet, van Gilst, Wiek H., De Boer, Rudolf A., Silljé, Herman H.?W.
Magazine: Bioassays
Auteur: Tigchelaar, Wardit, De Jong, Anne Margreet, van Gilst, Wiek H., De Boer, Rudolf A., Silljé, Herman H.?W.
Magazine: Bioassays
Titel: Streptococcus pneumoniae Invades Endothelial Host Cells via Multiple Pathways and Is Killed in a Lysosome Dependent Manner
Auteur: Gradstedt, Henrik, Iovino, Federico, Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Auteur: Gradstedt, Henrik, Iovino, Federico, Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Titel: The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
Auteur: Kakkar, Vaishali, Månsson, Cecilia, de Mattos, Eduardo P., Bergink, Steven, van der Zwaag, Marianne, van Waarde, Maria A.W.H., Kloosterhuis, Niels J., Melki, Ronald, van Cruchten, Remco T.P., Al-Karadaghi, Salam, Arosio, Paolo, Dobson, Christopher M., Knowles, Tuomas P.J., Bates, Gillian P., van Deursen, Jan M., Linse, Sara, van de Sluis, Bart, Emanuelsson, Cecilia, Kampinga, Harm H.
Magazine: Molecular Cell
Auteur: Kakkar, Vaishali, Månsson, Cecilia, de Mattos, Eduardo P., Bergink, Steven, van der Zwaag, Marianne, van Waarde, Maria A.W.H., Kloosterhuis, Niels J., Melki, Ronald, van Cruchten, Remco T.P., Al-Karadaghi, Salam, Arosio, Paolo, Dobson, Christopher M., Knowles, Tuomas P.J., Bates, Gillian P., van Deursen, Jan M., Linse, Sara, van de Sluis, Bart, Emanuelsson, Cecilia, Kampinga, Harm H.
Magazine: Molecular Cell
Titel: Nonviral Gene Delivery Vectors Use Syndecan-Dependent Transport Mechanisms in Filopodia To Reach the Cell Surface
Auteur: Rehman, Zia ur, Sjollema, Klaas A., Kuipers, Jeroen, Hoekstra, Dick, Zuhorn, Inge S.
Magazine: American chemical society (ACS) chemical biology
Auteur: Rehman, Zia ur, Sjollema, Klaas A., Kuipers, Jeroen, Hoekstra, Dick, Zuhorn, Inge S.
Magazine: American chemical society (ACS) chemical biology
Titel: The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes
Auteur: van Dongen, Joris A., Stevens, Hieronymus P., Parvizi, Mojtaba, van der Lei, Berend, Harmsen, Martin C.
Magazine: Wound Repair and Regeneration
Auteur: van Dongen, Joris A., Stevens, Hieronymus P., Parvizi, Mojtaba, van der Lei, Berend, Harmsen, Martin C.
Magazine: Wound Repair and Regeneration
Titel: Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening
Auteur: Raj, Divya D. A., Moser, Jill, van der Pol, Susanne M. A., van Os, Ronald P., Holtman, Inge R., Brouwer, Nieske, Oeseburg, Hisko, Schaafsma, Wandert, Wesseling, Evelyn M., den Dunnen, Wilfred, Biber, Knut P. H., de Vries, Helga E., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Magazine: Aging Cell
Auteur: Raj, Divya D. A., Moser, Jill, van der Pol, Susanne M. A., van Os, Ronald P., Holtman, Inge R., Brouwer, Nieske, Oeseburg, Hisko, Schaafsma, Wandert, Wesseling, Evelyn M., den Dunnen, Wilfred, Biber, Knut P. H., de Vries, Helga E., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Magazine: Aging Cell
Titel: CD16+ monocytes with smooth muscle cell characteristics are reduced in human renal chronic transplant dysfunction
Auteur: Boersema, M., van den Born, J.C., van Ark, J., Harms, G., Seelen, M.A., van Dijk, M.C.R.F., van Goor, H., Navis, G.J., Popa, E.R., Hillebrands, J.L.
Magazine: Immunobiology
Auteur: Boersema, M., van den Born, J.C., van Ark, J., Harms, G., Seelen, M.A., van Dijk, M.C.R.F., van Goor, H., Navis, G.J., Popa, E.R., Hillebrands, J.L.
Magazine: Immunobiology
Titel: The function of the ATP-binding cassette (ABC) transporter ABCB1 is not susceptible to actin disruption
Auteur: Meszaros, Peter, Hummel, Ina, Klappe, Karin, Draghiciu, Oana, Hoekstra, Dick, Kok, Jan W.
Magazine: Biochimica et Biophysica Acta
Auteur: Meszaros, Peter, Hummel, Ina, Klappe, Karin, Draghiciu, Oana, Hoekstra, Dick, Kok, Jan W.
Magazine: Biochimica et Biophysica Acta
Titel: AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates
Cardiomyocyte Growth via the Akt Pathway
Auteur: Hongjuan Yu, Wardit Tigchelaar, Bo Lu, Wiek H. van Gilst, Rudolf A. de Boer, B. Daan Westenbrink, Herman H. W. Silljé
Magazine: International Journal of Molecular Sciences
Auteur: Hongjuan Yu, Wardit Tigchelaar, Bo Lu, Wiek H. van Gilst, Rudolf A. de Boer, B. Daan Westenbrink, Herman H. W. Silljé
Magazine: International Journal of Molecular Sciences
Titel: The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis
Auteur: Mia, Masum M., Bank, Ruud A.
Magazine: Cell tissue research
Auteur: Mia, Masum M., Bank, Ruud A.
Magazine: Cell tissue research
Titel: Proteinuria Triggers Renal Lymphangiogenesis Prior to
the Development of Interstitial Fibrosis
Auteur: Saleh Yazdani, Fariba Poosti, Andrea B. Kramer, Katarina Mirkovic, Arjan J. Kwakernaak, Menno Hovingh, Maartje C. J. Slagman, Klaas A. Sjollema, Martin H. de Borst, Gerjan Navis, Harry van Goor, Jacob van den Born
Magazine: PLoS ONE
Auteur: Saleh Yazdani, Fariba Poosti, Andrea B. Kramer, Katarina Mirkovic, Arjan J. Kwakernaak, Menno Hovingh, Maartje C. J. Slagman, Klaas A. Sjollema, Martin H. de Borst, Gerjan Navis, Harry van Goor, Jacob van den Born
Magazine: PLoS ONE
Titel: Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training.
Auteur: Fornari RV, Wichmann R, Atucha E, Desprez T, Eggens-Meijer E, Roozendaal B.
Magazine: Frontiers in Behavioral Neuroscience
Auteur: Fornari RV, Wichmann R, Atucha E, Desprez T, Eggens-Meijer E, Roozendaal B.
Magazine: Frontiers in Behavioral Neuroscience
Titel: Hypoxia Promotes Proliferation of Human Myogenic
Satellite Cells: A Potential Benefactor in Tissue Engineering
of Skeletal Muscle
Auteur: Merel Koning, M.D., Paul M.N. Werker, M.D., Ph.D., Marja J.A. van Luyn, Ph.D., and Martin C. Harmsen, Ph.D.
Magazine: Tissue Engineering Part A
Auteur: Merel Koning, M.D., Paul M.N. Werker, M.D., Ph.D., Marja J.A. van Luyn, Ph.D., and Martin C. Harmsen, Ph.D.
Magazine: Tissue Engineering Part A
Titel: Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma
Auteur: Li, Jun, Kluiver, Joost, Osinga, Jan, Westers, Helga, van Werkhoven, Maaike B, Seelen, Marc A., Sijmons, Rolf H., van den Berg, Anke, Kok, Klaas
Magazine: Neoplasia
Auteur: Li, Jun, Kluiver, Joost, Osinga, Jan, Westers, Helga, van Werkhoven, Maaike B, Seelen, Marc A., Sijmons, Rolf H., van den Berg, Anke, Kok, Klaas
Magazine: Neoplasia
Titel: Destruction of Tissue, Cells and Organelles in Type 1 Diabetic Rats Presented at Macromolecular Resolution
Auteur: Ravelli, Raimond B. G., Kalicharan, Ruby D., Avramut, M. Cristina, Sjollema, Klaas A., Pronk, Joachim W., Dijk, Freark, Koster, Abraham J., Visser, Jeroen T. J., Faas, Frank G. A., Giepmans, Ben N. G.
Magazine: Scientific Reports
Auteur: Ravelli, Raimond B. G., Kalicharan, Ruby D., Avramut, M. Cristina, Sjollema, Klaas A., Pronk, Joachim W., Dijk, Freark, Koster, Abraham J., Visser, Jeroen T. J., Faas, Frank G. A., Giepmans, Ben N. G.
Magazine: Scientific Reports
Titel: Tubular epithelial syndecan-1 maintains renal
function in murine ischemia/reperfusion and
human transplantation
Auteur: Johanna W.A.M. Celie, Kiran K. Katta, Saritha Adepu, Wynand B.W.H. Melenhorst, Rogier M. Reijmers, Edith M. Slot, Robert H.J. Beelen, Marcel Spaargaren, Rutger J. Ploeg, Gerjan Navis, Jaap J. Homan van der Heide, Marcory C.R.F. van Dijk, Harry van Goor and Jacob van den Born
Magazine: Kidney International
Auteur: Johanna W.A.M. Celie, Kiran K. Katta, Saritha Adepu, Wynand B.W.H. Melenhorst, Rogier M. Reijmers, Edith M. Slot, Robert H.J. Beelen, Marcel Spaargaren, Rutger J. Ploeg, Gerjan Navis, Jaap J. Homan van der Heide, Marcory C.R.F. van Dijk, Harry van Goor and Jacob van den Born
Magazine: Kidney International
Titel: Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers.
Auteur: van Ark J, Moser J, Lexis CP, Bekkema F, Pop I, van der Horst IC, Zeebregts CJ, van Goor H, Wolffenbuttel BH, Hillebrands JL.
Magazine: Diabetologia
Auteur: van Ark J, Moser J, Lexis CP, Bekkema F, Pop I, van der Horst IC, Zeebregts CJ, van Goor H, Wolffenbuttel BH, Hillebrands JL.
Magazine: Diabetologia
Titel: Mutations in potassium channelkcnd3cause spinocerebellar ataxia type 19
Auteur: Duarri, Anna, Jezierska, Justyna, Fokkens, Michiel, Meijer, Michel, Schelhaas, Helenius J., den Dunnen, Wilfred F. A., van Dijk, Freerk, Verschuuren-Bemelmans, Corien, Hageman, Gerard, van de Vlies, Pieter, Küsters, Benno, van de Warrenburg, Bart P., Kremer, Berry, Wijmenga, Cisca, Sinke, Richard J., Swertz, Morris A., Kampinga, Harm H., Boddeke, Erik, Verbeek, Dineke S.
Magazine: Annals of Neurology
Auteur: Duarri, Anna, Jezierska, Justyna, Fokkens, Michiel, Meijer, Michel, Schelhaas, Helenius J., den Dunnen, Wilfred F. A., van Dijk, Freerk, Verschuuren-Bemelmans, Corien, Hageman, Gerard, van de Vlies, Pieter, Küsters, Benno, van de Warrenburg, Bart P., Kremer, Berry, Wijmenga, Cisca, Sinke, Richard J., Swertz, Morris A., Kampinga, Harm H., Boddeke, Erik, Verbeek, Dineke S.
Magazine: Annals of Neurology
Titel: The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction
Auteur: Ye Q, Harmsen MC, van Luyn MJ, Bank RA
Magazine: Biomaterials
Auteur: Ye Q, Harmsen MC, van Luyn MJ, Bank RA
Magazine: Biomaterials
Titel: Endo180 and MT1-MMP are involved in the phagocytosis of collagen scaffolds by macrophages and is regulated by interferon-gamma
Auteur: Ye Q, Xing Q, Ren Y, Harmsen MC, Bank RA
Magazine: European Cells and Materials
Auteur: Ye Q, Xing Q, Ren Y, Harmsen MC, Bank RA
Magazine: European Cells and Materials
Titel: Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targetingex vivo
Auteur: Poosti, Fariba, Pham, Bao Tung, Oosterhuis, Dorenda, Poelstra, Klaas, van Goor, Harry, Olinga, Peter, Hillebrands, Jan-Luuk
Magazine: Disease Models & Mechanisms
Auteur: Poosti, Fariba, Pham, Bao Tung, Oosterhuis, Dorenda, Poelstra, Klaas, van Goor, Harry, Olinga, Peter, Hillebrands, Jan-Luuk
Magazine: Disease Models & Mechanisms
Titel: Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress
Auteur: Moonen, Jan-Renier A.J., Lee, Ee Soo, Schmidt, Marc, Maleszewska, Monika, Koerts, Jasper A., Brouwer, Linda A., van Kooten, Theo G., van Luyn, Marja J.A., Zeebregts, Clark J., Krenning, Guido, Harmsen, Martin C.
Magazine: Cardiovascular Research
Auteur: Moonen, Jan-Renier A.J., Lee, Ee Soo, Schmidt, Marc, Maleszewska, Monika, Koerts, Jasper A., Brouwer, Linda A., van Kooten, Theo G., van Luyn, Marja J.A., Zeebregts, Clark J., Krenning, Guido, Harmsen, Martin C.
Magazine: Cardiovascular Research
Titel: Immunolabeling artifacts and the need for live-cell imaging
Auteur: Schnell, Ulrike, Dijk, Freark, Sjollema, Klaas A, Giepmans, Ben N G
Magazine: Nature Methods
Auteur: Schnell, Ulrike, Dijk, Freark, Sjollema, Klaas A, Giepmans, Ben N G
Magazine: Nature Methods
Titel: HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-?B p65 transcriptional activity
Auteur: Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Magazine: Biochemical Pharmacology
Auteur: Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Magazine: Biochemical Pharmacology
Titel: Circulating alpha-klotho levels are not disturbed
in patients with type 2 diabetes with and without
macrovascular disease in the absence of
nephropathy
Auteur: Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
Magazine: Cardiovascular Diabetology
Auteur: Joris van Ark, Hans-Peter Hammes, Marcory C R F van Dijk, Marc G Vervloet, Bruce H R Wolffenbuttel, Harry van Goor and Jan-Luuk Hillebrands
Magazine: Cardiovascular Diabetology
Titel: Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice
Auteur: Poosti, Fariba, Bansal, Ruchi, Yazdani, Saleh, Prakash, Jai, Beljaars, Leonie, Born, Jacob van den, de Borst, Martin H., van Goor, Harry, Hillebrands, Jan-Luuk, Poelstra, Klaas
Magazine: Oncotarget
Auteur: Poosti, Fariba, Bansal, Ruchi, Yazdani, Saleh, Prakash, Jai, Beljaars, Leonie, Born, Jacob van den, de Borst, Martin H., van Goor, Harry, Hillebrands, Jan-Luuk, Poelstra, Klaas
Magazine: Oncotarget
Titel: Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts
Auteur: Wedel, Johannes, Jansen, Patrick A.M., Botman, Peter N.M., Rutjes, Floris P.J.T., Schalkwijk, Joost, Hillebrands, Jan-Luuk
Magazine: Transplantation
Auteur: Wedel, Johannes, Jansen, Patrick A.M., Botman, Peter N.M., Rutjes, Floris P.J.T., Schalkwijk, Joost, Hillebrands, Jan-Luuk
Magazine: Transplantation
Titel: The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells
Auteur: Hajmousa, Ghazaleh, Vogelaar, Pieter, Brouwer, Linda A., van der Graaf, Adrianus C., Henning, Robert H., Krenning, Guido
Magazine: Biomaterials
Auteur: Hajmousa, Ghazaleh, Vogelaar, Pieter, Brouwer, Linda A., van der Graaf, Adrianus C., Henning, Robert H., Krenning, Guido
Magazine: Biomaterials
Titel: Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes
Auteur: Georgieva, Julia V., Brinkhuis, René P., Stojanov, Katica, Weijers, Carel A. G. M., Zuilhof, Han, Rutjes, Floris P. J. T., Hoekstra, Dick, van Hest, Jan C. M., Zuhorn, Inge S.
Magazine: Angewandte Chemie International Edition
Auteur: Georgieva, Julia V., Brinkhuis, René P., Stojanov, Katica, Weijers, Carel A. G. M., Zuilhof, Han, Rutjes, Floris P. J. T., Hoekstra, Dick, van Hest, Jan C. M., Zuhorn, Inge S.
Magazine: Angewandte Chemie International Edition
Titel: Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy
Auteur: Tigchelaar, Wardit, Yu, Hongjuan, de Jong, Anne Margreet, van Gilst, Wiek H., van der Harst, Pim, Westenbrink, B. Daan, de Boer, Rudolf A., Silljé, Herman H. W.
Magazine: American Journal of Physiology - Endocrinology and Metabolism
Auteur: Tigchelaar, Wardit, Yu, Hongjuan, de Jong, Anne Margreet, van Gilst, Wiek H., van der Harst, Pim, Westenbrink, B. Daan, de Boer, Rudolf A., Silljé, Herman H. W.
Magazine: American Journal of Physiology - Endocrinology and Metabolism
Titel: Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction
Auteur: Katta K, Boersema M, Adepu S, Rienstra H, Celie JW, Mencke R, Molema G, van Goor H, Berden JH, Navis G, Hillebrands JL, van den Born J.
Magazine: American Journal of Pathology
Auteur: Katta K, Boersema M, Adepu S, Rienstra H, Celie JW, Mencke R, Molema G, van Goor H, Berden JH, Navis G, Hillebrands JL, van den Born J.
Magazine: American Journal of Pathology
Titel: Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2
Auteur: Gjaltema, Rutger A. F., van der Stoel, Miesje M., Boersema, Miriam, Bank, Ruud A.
Magazine: Proceedings of the National Academy of Sciences
Auteur: Gjaltema, Rutger A. F., van der Stoel, Miesje M., Boersema, Miriam, Bank, Ruud A.
Magazine: Proceedings of the National Academy of Sciences
Titel: Ex vivoaddition of fibrinogen concentrate improves the fibrin network structure in plasma samples taken during liver transplantation
Auteur: Groeneveld, D. J., Adelmeijer, J., Hugenholtz, G. C. G., Ariëns, R. A. S., Porte, R. J., Lisman, T.
Magazine: Journal of Thrombosis and Haemostasis
Auteur: Groeneveld, D. J., Adelmeijer, J., Hugenholtz, G. C. G., Ariëns, R. A. S., Porte, R. J., Lisman, T.
Magazine: Journal of Thrombosis and Haemostasis
Titel: MicroRNA-1 and microRNA-206 improve differentiation potential of human satellite cells: A novel approach for tissue engineering of skeletal muscle.
Auteur: Koning M, Werker P, Bank RA, Harmsen MC
Magazine: Tissue Engineering Part A
Auteur: Koning M, Werker P, Bank RA, Harmsen MC
Magazine: Tissue Engineering Part A
Titel: TGF-ß is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion
Auteur: Joseph, J V, Conroy, S, Tomar, T, Eggens-Meijer, E, Bhat, K, Copray, S, Walenkamp, A M E, Boddeke, E, Balasubramanyian, V, Wagemakers, M, den Dunnen, W F A, Kruyt, F A E
Magazine: Cell Death and Disease
Auteur: Joseph, J V, Conroy, S, Tomar, T, Eggens-Meijer, E, Bhat, K, Copray, S, Walenkamp, A M E, Boddeke, E, Balasubramanyian, V, Wagemakers, M, den Dunnen, W F A, Kruyt, F A E
Magazine: Cell Death and Disease
Titel: Cystathionine g-Lyase Protects against Renal
Ischemia/Reperfusion by Modulating Oxidative Stress
Auteur: Eelke M. Bos, Rui Wang, Pauline M. Snijder, Miriam Boersema, Jeffrey Damman, Ming Fu, Jill Moser, Jan-Luuk Hillebrands, Rutger J. Ploeg, Guangdong Yang, Henri G.D. Leuvenink, and Harry van Goor
Magazine: Journal of the American Society of Nephrology
Auteur: Eelke M. Bos, Rui Wang, Pauline M. Snijder, Miriam Boersema, Jeffrey Damman, Ming Fu, Jill Moser, Jan-Luuk Hillebrands, Rutger J. Ploeg, Guangdong Yang, Henri G.D. Leuvenink, and Harry van Goor
Magazine: Journal of the American Society of Nephrology
Titel: Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo
Auteur: Kowalski, Piotr S., Zwiers, Peter J., Morselt, Henriëtte W.M., Kuldo, Joanna M., Leus, Niek G.J., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.
Magazine: Journal of Controlled Release
Auteur: Kowalski, Piotr S., Zwiers, Peter J., Morselt, Henriëtte W.M., Kuldo, Joanna M., Leus, Niek G.J., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.
Magazine: Journal of Controlled Release
Titel: Anti-VCAM-1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells
Auteur: Kowalski, Piotr S., Lintermans, Lucas L., Morselt, Henriëtte W. M., Leus, Niek G. J., Ruiters, Marcel H. J., Molema, Grietje, Kamps, Jan A. A. M.
Magazine: Molecular Pharmacology
Auteur: Kowalski, Piotr S., Lintermans, Lucas L., Morselt, Henriëtte W. M., Leus, Niek G. J., Ruiters, Marcel H. J., Molema, Grietje, Kamps, Jan A. A. M.
Magazine: Molecular Pharmacology
Titel: Correlated light microscopy and electron microscopy
Auteur: Sjollema KA, Schnell U, Kuipers J, Kalicharan R, Giepmans BN
Magazine: Methods in Cell Biology
Auteur: Sjollema KA, Schnell U, Kuipers J, Kalicharan R, Giepmans BN
Magazine: Methods in Cell Biology
Titel: Functional Analysis Helps to Define KCNC3 Mutational Spectrum in Dutch Ataxia Cases
Auteur: Duarri, Anna, Nibbeling, Esther A. R., Fokkens, Michiel R., Meijer, Michel, Boerrigter, Melissa, Verschuuren-Bemelmans, Corien C., Kremer, Berry P. H., van de Warrenburg, Bart P., Dooijes, Dennis, Boddeke, Erik, Sinke, Richard J., Verbeek, Dineke S.
Magazine: PLoS ONE
Auteur: Duarri, Anna, Nibbeling, Esther A. R., Fokkens, Michiel R., Meijer, Michel, Boerrigter, Melissa, Verschuuren-Bemelmans, Corien C., Kremer, Berry P. H., van de Warrenburg, Bart P., Dooijes, Dennis, Boddeke, Erik, Sinke, Richard J., Verbeek, Dineke S.
Magazine: PLoS ONE
Titel: Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate
Auteur: Zaferani, A., Vives, R. R., van der Pol, P., Navis, G. J., Daha, M. R., van Kooten, C., Lortat-Jacob, H., Seelen, M. A., van den Born, J.
Magazine: Journal of Biological Chemistry
Auteur: Zaferani, A., Vives, R. R., van der Pol, P., Navis, G. J., Daha, M. R., van Kooten, C., Lortat-Jacob, H., Seelen, M. A., van den Born, J.
Magazine: Journal of Biological Chemistry
Titel: SCA14 mutation V138E leads to partly unfolded PKC? associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization
Auteur: Jezierska, Justyna, Goedhart, Joachim, Kampinga, Harm H., Reits, Eric A., Verbeek, Dineke S.
Magazine: Journal of Neurochemistry
Auteur: Jezierska, Justyna, Goedhart, Joachim, Kampinga, Harm H., Reits, Eric A., Verbeek, Dineke S.
Magazine: Journal of Neurochemistry
Titel: Extracellular matrix components of adipose derived stromal cells promote alignment, organization, and maturation of cardiomyocytesin vitro
Auteur: Przybyt, Ewa, van Luyn, Marja J. A., Harmsen, Martin C.
Magazine: Journal of Biomedical Materials Research Part B
Auteur: Przybyt, Ewa, van Luyn, Marja J. A., Harmsen, Martin C.
Magazine: Journal of Biomedical Materials Research Part B
Titel: Pyruvate Oxidase Influences the Sugar Utilization Pattern and Capsule Production in Streptococcus pneumoniae
Auteur: Carvalho, Sandra M., Farshchi Andisi, Vahid, Gradstedt, Henrik, Neef, Jolanda, Kuipers, Oscar P., Neves, Ana R., Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Auteur: Carvalho, Sandra M., Farshchi Andisi, Vahid, Gradstedt, Henrik, Neef, Jolanda, Kuipers, Oscar P., Neves, Ana R., Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Titel: Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury
Auteur: Moser, Jill, van Ark, Joris, van Dijk, Marcory C., Greiner, Dale L., Shultz, Leonard D., van Goor, Harry, Hillebrands, Jan-Luuk
Magazine: science reports
Auteur: Moser, Jill, van Ark, Joris, van Dijk, Marcory C., Greiner, Dale L., Shultz, Leonard D., van Goor, Harry, Hillebrands, Jan-Luuk
Magazine: science reports
Titel: Selective delivery of IFN- to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis
Auteur: Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Post, E., Klok, P., van den Born, J., de Borst, M. H., van Goor, H., Poelstra, K., Hillebrands, J.-L.
Magazine: The FASEB Journal
Auteur: Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Post, E., Klok, P., van den Born, J., de Borst, M. H., van Goor, H., Poelstra, K., Hillebrands, J.-L.
Magazine: The FASEB Journal
Titel: YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts
Auteur: Piersma, Bram, de Rond, Saskia, Werker, Paul M.N., Boo, Stellar, Hinz, Boris, van Beuge, Marike M., Bank, Ruud A.
Magazine: American Journal of Pathology
Auteur: Piersma, Bram, de Rond, Saskia, Werker, Paul M.N., Boo, Stellar, Hinz, Boris, van Beuge, Marike M., Bank, Ruud A.
Magazine: American Journal of Pathology
Titel: FGF2 inhibits endothelial-mesenchymal transition through microRNA-20a-mediated repression of canonical TGF- signaling
Auteur: Correia, A. C. P., Moonen, J.-R. A. J., Brinker, M. G. L., Krenning, G.
Magazine: Journal of Cell Science
Auteur: Correia, A. C. P., Moonen, J.-R. A. J., Brinker, M. G. L., Krenning, G.
Magazine: Journal of Cell Science
Titel: Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
Auteur: van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., Baanstra, M., van der Laan, H. P., Kierkels, R. G. J., van der Schaaf, A., Witjes, M. J., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Wu, J., Coppes, R. P.
Magazine: Science translational medicine
Auteur: van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., Baanstra, M., van der Laan, H. P., Kierkels, R. G. J., van der Schaaf, A., Witjes, M. J., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Wu, J., Coppes, R. P.
Magazine: Science translational medicine
Titel: CD20+T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer
Auteur: de Bruyn, Marco, Wiersma, Valerie R, Wouters, Maartje C A, Samplonius, Douwe F, Klip, Harry G, Helfrich, Wijnand, Nijman, Hans W, Eggleton, Paul, Bremer, Edwin
Magazine: OncoImmunology
Auteur: de Bruyn, Marco, Wiersma, Valerie R, Wouters, Maartje C A, Samplonius, Douwe F, Klip, Harry G, Helfrich, Wijnand, Nijman, Hans W, Eggleton, Paul, Bremer, Edwin
Magazine: OncoImmunology
Titel: The role of collagen receptors Endo180 and DDR-2 in the foreign body reaction against non-crosslinked collagen and gelatin
Auteur: Ye Q, Harmsen MC, Ren Y, Bank RA
Magazine: Biomaterials
Auteur: Ye Q, Harmsen MC, Ren Y, Bank RA
Magazine: Biomaterials
Titel: Interleukin-1ß Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-ß1
Auteur: Mia, Masum M., Boersema, Miriam, Bank, Ruud A.
Magazine: PLoS ONE
Auteur: Mia, Masum M., Boersema, Miriam, Bank, Ruud A.
Magazine: PLoS ONE
Titel: Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis
Auteur: Iovino, Federico, Orihuela, Carlos J., Moorlag, Henk E., Molema, Grietje, Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Auteur: Iovino, Federico, Orihuela, Carlos J., Moorlag, Henk E., Molema, Grietje, Bijlsma, Jetta J. E.
Magazine: PLoS ONE
Titel: Gaseous Hydrogen Sulfide Protects against Myocardial
Ischemia-Reperfusion Injury in Mice Partially
Independent from Hypometabolism
Auteur: Pauline M. Snijder, Rudolf A. de Boer, Eelke M. Bos, Joost C. van den Born, Willem-Peter T. Ruifrok, Inge Vreeswijk-Baudoin, Marcory C. R. F. van Dijk, Jan-Luuk Hillebrands, Henri G. D. Leuvenink, Harry van Goor
Magazine: PLoS ONE
Auteur: Pauline M. Snijder, Rudolf A. de Boer, Eelke M. Bos, Joost C. van den Born, Willem-Peter T. Ruifrok, Inge Vreeswijk-Baudoin, Marcory C. R. F. van Dijk, Jan-Luuk Hillebrands, Henri G. D. Leuvenink, Harry van Goor
Magazine: PLoS ONE
Titel: Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained
Auteur: Hajmousa, Ghazaleh, Elorza, Alvaro A., Nies, Vera J.M., Jensen, Erik L., Nagy, Ruxandra A., Harmsen, Martin C.
Magazine: Stem cells and development
Auteur: Hajmousa, Ghazaleh, Elorza, Alvaro A., Nies, Vera J.M., Jensen, Erik L., Nagy, Ruxandra A., Harmsen, Martin C.
Magazine: Stem cells and development
Titel: Basement Membrane Zone Collagens XV and XVIII/Proteoglycans Mediate Leukocyte Influx in Renal Ischemia/Reperfusion
Auteur: Zaferani, Azadeh, Talsma, Ditmer T., Yazdani, Saleh, Celie, Johanna W. A. M., Aikio, Mari, Heljasvaara, Ritva, Navis, Gerjan J., Pihlajaniemi, Taina, van den Born, Jacob
Magazine: PLoS ONE
Auteur: Zaferani, Azadeh, Talsma, Ditmer T., Yazdani, Saleh, Celie, Johanna W. A. M., Aikio, Mari, Heljasvaara, Ritva, Navis, Gerjan J., Pihlajaniemi, Taina, van den Born, Jacob
Magazine: PLoS ONE
Titel: The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence
Auteur: Maleszewska, Monika, Vanchin, Byambasuren, Harmsen, Martin C., Krenning, Guido
Magazine: Angiogenesis
Auteur: Maleszewska, Monika, Vanchin, Byambasuren, Harmsen, Martin C., Krenning, Guido
Magazine: Angiogenesis
Titel: Selective targeting of CREB-binding protein/ß-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle
Auteur: Koopmans, Tim, Crutzen, Stijn, Menzen, Mark H, Halayko, Andrew J, Hackett, Tillie-Louise, Knight, Darryl A, Gosens, Reinoud
Magazine: British Journal of Pharmacology
Auteur: Koopmans, Tim, Crutzen, Stijn, Menzen, Mark H, Halayko, Andrew J, Hackett, Tillie-Louise, Knight, Darryl A, Gosens, Reinoud
Magazine: British Journal of Pharmacology
Titel: CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma
Auteur: Workel, Hagma H., Komdeur, Fenne L., Wouters, Maartje C.A., Plat, Annechien, Klip, Harry G., Eggink, Florine A., Wisman, G. Bea A., Arts, Henriette J.G., Oonk, Maaike H.M., Mourits, Marian J.E., Yigit, Refika, Versluis, Marco, Duiker, Evelien W., Hollema, Harry, de Bruyn, Marco, Nijman, Hans W.
Magazine: European Journal of Cancer
Auteur: Workel, Hagma H., Komdeur, Fenne L., Wouters, Maartje C.A., Plat, Annechien, Klip, Harry G., Eggink, Florine A., Wisman, G. Bea A., Arts, Henriette J.G., Oonk, Maaike H.M., Mourits, Marian J.E., Yigit, Refika, Versluis, Marco, Duiker, Evelien W., Hollema, Harry, de Bruyn, Marco, Nijman, Hans W.
Magazine: European Journal of Cancer
Titel: Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation.
Auteur: Teuling E, Bourgonje A, Veenje S, Thijssen K, de Boer J, van der Velde J, Swertz M, Nollen E.
Magazine: PLOS Currents: Huntington Disease
Auteur: Teuling E, Bourgonje A, Veenje S, Thijssen K, de Boer J, van der Velde J, Swertz M, Nollen E.
Magazine: PLOS Currents: Huntington Disease
Titel: CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRab+ CD8ab+ T cells that can be targeted for cancer immunotherapy
Auteur: Komdeur, Fenne L., Wouters, Maartje C.A., Workel, Hagma H., Tijans, Aline M., Terwindt, Anouk L.J., Brunekreeft, Kim L., Plat, Annechien, Klip, Harry G., Eggink, Florine A., Leffers, Ninke, Helfrich, Wijnand, Samplonius, Douwe F., Bremer, Edwin, Wisman, G Bea A., Daemen, Toos, Duiker, Evelien W., Hollema, Harry, Nijman, Hans W., de Bruyn, Marco
Magazine: Oncotarget
Auteur: Komdeur, Fenne L., Wouters, Maartje C.A., Workel, Hagma H., Tijans, Aline M., Terwindt, Anouk L.J., Brunekreeft, Kim L., Plat, Annechien, Klip, Harry G., Eggink, Florine A., Leffers, Ninke, Helfrich, Wijnand, Samplonius, Douwe F., Bremer, Edwin, Wisman, G Bea A., Daemen, Toos, Duiker, Evelien W., Hollema, Harry, Nijman, Hans W., de Bruyn, Marco
Magazine: Oncotarget
Titel: Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
Auteur: Maimets, Martti, Rocchi, Cecilia, Bron, Reinier, Pringle, Sarah, Kuipers, Jeroen, Giepmans, Ben N.G., Vries, Robert G.J., Clevers, Hans, de Haan, Gerald, van Os, Ronald, Coppes, Robert P.
Magazine: Stem Cell Reports
Auteur: Maimets, Martti, Rocchi, Cecilia, Bron, Reinier, Pringle, Sarah, Kuipers, Jeroen, Giepmans, Ben N.G., Vries, Robert G.J., Clevers, Hans, de Haan, Gerald, van Os, Ronald, Coppes, Robert P.
Magazine: Stem Cell Reports
Titel: Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoforms
Auteur: Ozgen, Hande, Kahya, Nicoletta, de Jonge, Jenny C., Smith, Graham S.T., Harauz, George, Hoekstra, Dick, Baron, Wia
Magazine: Biochimica et Biophysica Acta
Auteur: Ozgen, Hande, Kahya, Nicoletta, de Jonge, Jenny C., Smith, Graham S.T., Harauz, George, Hoekstra, Dick, Baron, Wia
Magazine: Biochimica et Biophysica Acta
Titel: Detailed Analysis of the Genetic and Epigenetic Signatures of iPSC-Derived Mesodiencephalic Dopaminergic Neurons
Auteur: Roessler, Reinhard, Smallwood, Sebastien A., Veenvliet, Jesse V., Pechlivanoglou, Petros, Peng, Su-Ping, Chakrabarty, Koushik, Groot-Koerkamp, Marian J.A., Pasterkamp, R. Jeroen, Wesseling, Evelyn, Kelsey, Gavin, Boddeke, Erik, Smidt, Marten P., Copray, Sjef
Magazine: Journal of Stem Cells
Auteur: Roessler, Reinhard, Smallwood, Sebastien A., Veenvliet, Jesse V., Pechlivanoglou, Petros, Peng, Su-Ping, Chakrabarty, Koushik, Groot-Koerkamp, Marian J.A., Pasterkamp, R. Jeroen, Wesseling, Evelyn, Kelsey, Gavin, Boddeke, Erik, Smidt, Marten P., Copray, Sjef
Magazine: Journal of Stem Cells
Titel: POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
Auteur: van Gool, I. C., Eggink, F. A., Freeman-Mills, L., Stelloo, E., Marchi, E., de Bruyn, M., Palles, C., Nout, R. A., de Kroon, C. D., Osse, E. M., Klenerman, P., Creutzberg, C. L., Tomlinson, I. P. M., Smit, V. T. H. B. M., Nijman, H. W., Bosse, T., Church, D. N.
Magazine: Clinical Cancer Research
Auteur: van Gool, I. C., Eggink, F. A., Freeman-Mills, L., Stelloo, E., Marchi, E., de Bruyn, M., Palles, C., Nout, R. A., de Kroon, C. D., Osse, E. M., Klenerman, P., Creutzberg, C. L., Tomlinson, I. P. M., Smit, V. T. H. B. M., Nijman, H. W., Bosse, T., Church, D. N.
Magazine: Clinical Cancer Research
Titel: Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
Auteur: Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Klip, H. G., Plat, A., Kooi, N. M., Wisman, G. B. A., Mourits, M. J. E., Arts, H. J. G., Oonk, M. H. M., Yigit, R., de Jong, S., Melief, C. J. M., Hollema, H., Duiker, E. W., Daemen, T., de Bruyn, M., Nijman, H. W.
Magazine: Clinical Cancer Research
Auteur: Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Klip, H. G., Plat, A., Kooi, N. M., Wisman, G. B. A., Mourits, M. J. E., Arts, H. J. G., Oonk, M. H. M., Yigit, R., de Jong, S., Melief, C. J. M., Hollema, H., Duiker, E. W., Daemen, T., de Bruyn, M., Nijman, H. W.
Magazine: Clinical Cancer Research
Titel: N-octanoyl Dopamine Attenuates the Development of Transplant Vasculopathy in Rat Aortic Allografts Via Smooth Muscle Cell Protective Mechanisms
Auteur: Wedel, Johannes, Hottenrott, Maximilia C., Bulthuis, Marian, Huitema, Sippie, Yard, Benito A., Hillebrands, Jan-Luuk
Magazine: Transplantation
Auteur: Wedel, Johannes, Hottenrott, Maximilia C., Bulthuis, Marian, Huitema, Sippie, Yard, Benito A., Hillebrands, Jan-Luuk
Magazine: Transplantation
Titel: Absence of cell-surface EpCAM in congenital tufting enteropathy
Auteur: Schnell, U., Kuipers, J., Mueller, J. L., Veenstra-Algra, A., Sivagnanam, M., Giepmans, B. N. G.
Magazine: Human Molecular Genetics
Auteur: Schnell, U., Kuipers, J., Mueller, J. L., Veenstra-Algra, A., Sivagnanam, M., Giepmans, B. N. G.
Magazine: Human Molecular Genetics
Titel: Degradation of Granular Starch by the Bacterium Microbacterium aurum Strain B8.A Involves a Modular a-Amylase Enzyme System with FNIII and CBM25 Domains
Auteur: Valk, Vincent, Eeuwema, Wieger, Sarian, Fean D., van der Kaaij, Rachel M., Dijkhuizen, Lubbert
Magazine: Applied and Environmental Microbiology
Auteur: Valk, Vincent, Eeuwema, Wieger, Sarian, Fean D., van der Kaaij, Rachel M., Dijkhuizen, Lubbert
Magazine: Applied and Environmental Microbiology
Titel: Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis
Auteur: Rehman, Zia ur, Hoekstra, Dick, Zuhorn, Inge S.
Magazine: American chemical society (ACS) chemical biology
Auteur: Rehman, Zia ur, Hoekstra, Dick, Zuhorn, Inge S.
Magazine: American chemical society (ACS) chemical biology
Titel: Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22a expression in endothelial cells in response to interleukin-1ß and transforming growth factor-ß2
Auteur: Maleszewska, Monika, Gjaltema, Rutger A.F., Krenning, Guido, Harmsen, Martin C.
Magazine: Cell signalling
Auteur: Maleszewska, Monika, Gjaltema, Rutger A.F., Krenning, Guido, Harmsen, Martin C.
Magazine: Cell signalling
Titel: Bronchoconstriction Induces TGF-ß Release and Airway Remodelling in Guinea Pig Lung Slices
Auteur: Oenema, Tjitske A., Maarsingh, Harm, Smit, Marieke, Groothuis, Geny M. M., Meurs, Herman, Gosens, Reinoud
Magazine: PLoS ONE
Auteur: Oenema, Tjitske A., Maarsingh, Harm, Smit, Marieke, Groothuis, Geny M. M., Meurs, Herman, Gosens, Reinoud
Magazine: PLoS ONE
Titel: EpCAM proteolysis: new fragments with distinct functions?
Auteur: Schnell, Ulrike, Kuipers, Jeroen, Giepmans, Ben N. G.
Magazine: Bioscience Reports
Auteur: Schnell, Ulrike, Kuipers, Jeroen, Giepmans, Ben N. G.
Magazine: Bioscience Reports
Titel: Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma
Auteur: Renske A. de Jong, Ido P. Kema, Annemarie Boerma, H. Marike Boezen, Johannes J.L. van der Want, Marloes J.M. Gooden, Harry Hollema, Hans W. Nijman
Magazine: Gynecologic Oncology
Auteur: Renske A. de Jong, Ido P. Kema, Annemarie Boerma, H. Marike Boezen, Johannes J.L. van der Want, Marloes J.M. Gooden, Harry Hollema, Hans W. Nijman
Magazine: Gynecologic Oncology
Titel: Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
Auteur: Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Klip, H. G., Plat, A., Kooi, N. M., Wisman, G. B. A., Mourits, M. J. E., Arts, H. J. G., Oonk, M. H. M., Yigit, R., de Jong, S., Melief, C. J. M., Hollema, H., Duiker, E. W., Daemen, T., de Bruyn, M., Nijman, H. W.
Magazine: Clinical Cancer Research
Auteur: Wouters, M. C. A., Komdeur, F. L., Workel, H. H., Klip, H. G., Plat, A., Kooi, N. M., Wisman, G. B. A., Mourits, M. J. E., Arts, H. J. G., Oonk, M. H. M., Yigit, R., de Jong, S., Melief, C. J. M., Hollema, H., Duiker, E. W., Daemen, T., de Bruyn, M., Nijman, H. W.
Magazine: Clinical Cancer Research
Titel: Adipose Tissue–Derived Stromal Cells Inhibit TGF-ß1–Induced Differentiation of Human Dermal Fibroblasts and Keloid Scar–Derived Fibroblasts in a Paracrine Fashion
Auteur: Spiekman, Maroesjka, Przybyt, Ewa, Plantinga, Josée A., Gibbs, Susan, van der Lei, Berend, Harmsen, Martin C.
Magazine: Plastic and Reconstructive Surgery
Auteur: Spiekman, Maroesjka, Przybyt, Ewa, Plantinga, Josée A., Gibbs, Susan, van der Lei, Berend, Harmsen, Martin C.
Magazine: Plastic and Reconstructive Surgery
Titel: Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23
Auteur: Smeets, Cleo J. L. M., Jezierska, Justyna, Watanabe, Hiroyuki, Duarri, Anna, Fokkens, Michiel R., Meijer, Michel, Zhou, Qin, Yakovleva, Tania, Boddeke, Erik, den Dunnen, Wilfred, van Deursen, Jan, Bakalkin, Georgy, Kampinga, Harm H., van de Sluis, Bart, Verbeek, Dineke S.
Magazine: Brain
Auteur: Smeets, Cleo J. L. M., Jezierska, Justyna, Watanabe, Hiroyuki, Duarri, Anna, Fokkens, Michiel R., Meijer, Michel, Zhou, Qin, Yakovleva, Tania, Boddeke, Erik, den Dunnen, Wilfred, van Deursen, Jan, Bakalkin, Georgy, Kampinga, Harm H., van de Sluis, Bart, Verbeek, Dineke S.
Magazine: Brain
Titel: A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle
Auteur: Poppinga, Wilfred J., Heijink, Irene H., Holtzer, Laura J., Skroblin, Philipp, Klussmann, Enno, Halayko, Andrew J., Timens, Wim, Maarsingh, Harm, Schmidt, Martina
Magazine: American Journal of Physiology - Lung Cellular and Molecular Physiology
Auteur: Poppinga, Wilfred J., Heijink, Irene H., Holtzer, Laura J., Skroblin, Philipp, Klussmann, Enno, Halayko, Andrew J., Timens, Wim, Maarsingh, Harm, Schmidt, Martina
Magazine: American Journal of Physiology - Lung Cellular and Molecular Physiology
Titel: Hydrogen sulfide producing enzymes in pregnancy and preeclampsia
Auteur: K.M. Holwerda, E.M. Bos, A. Rajakumar,C. Ris-Stalpers, M.G. van Pampus, A. Timmer, J.J.H.M. Erwich, M.M. Faas, H. van Goor, A.T. Lely
Magazine: Placenta
Auteur: K.M. Holwerda, E.M. Bos, A. Rajakumar,C. Ris-Stalpers, M.G. van Pampus, A. Timmer, J.J.H.M. Erwich, M.M. Faas, H. van Goor, A.T. Lely
Magazine: Placenta
Titel: Modifiers of mutant huntingtin aggregationfunctional conservation of C. elegans-modifiers of polyglutamine aggregation
Auteur: Teuling, Eva, Bourgonje, Annika, Veenje, Sven, Thijssen, Karen, de Boer, Jelle, van der Velde, Joeri, Swertz, Morris, Nollen, Ellen
Magazine: PLOS Currents: Huntington Disease
Auteur: Teuling, Eva, Bourgonje, Annika, Veenje, Sven, Thijssen, Karen, de Boer, Jelle, van der Velde, Joeri, Swertz, Morris, Nollen, Ellen
Magazine: PLOS Currents: Huntington Disease
Titel: Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner
Auteur: Duarri, Anna, Lin, Meng-Chin A., Fokkens, Michiel R., Meijer, Michel, Smeets, Cleo J. L. M., Nibbeling, Esther A. R., Boddeke, Erik, Sinke, Richard J., Kampinga, Harm H., Papazian, Diane M., Verbeek, Dineke S.
Magazine: Life Sciences
Auteur: Duarri, Anna, Lin, Meng-Chin A., Fokkens, Michiel R., Meijer, Michel, Smeets, Cleo J. L. M., Nibbeling, Esther A. R., Boddeke, Erik, Sinke, Richard J., Kampinga, Harm H., Papazian, Diane M., Verbeek, Dineke S.
Magazine: Life Sciences
Titel: Development of recombinant collagen-peptide-based vehicles for delivery of adipose-derived stromal cells
Auteur: Parvizi, Mojtaba, Plantinga, Josée A., van Speuwel-Goossens, Carolina A.F.M., van Dongen, Elisabeth M.W.M., Kluijtmans, Sebastiaan G.J.M., Harmsen, Martin C.
Magazine: Journal of Biomedical Materials Research Part B
Auteur: Parvizi, Mojtaba, Plantinga, Josée A., van Speuwel-Goossens, Carolina A.F.M., van Dongen, Elisabeth M.W.M., Kluijtmans, Sebastiaan G.J.M., Harmsen, Martin C.
Magazine: Journal of Biomedical Materials Research Part B
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Eindverslag
In dit project bestond de investering uit een geavanceerd microscopie systeem (de TissueFAXS®) dat gebruikers in staat stelde tegelijkertijd de expressie van verschillende eiwitten op een individuele cel kwalitatief en kwantitatief in kaart te brengen. Deze analyses konden worden uitgevoerd op hele dunne plakjes weefsel, gekweekte cellen, of bacterien met als doel meer inzicht te verkrijgen in de rol die verschillende eiwitten spelen tijdens normale functie van cellen of juist bij het ontstaan van ziekten. Zonder dit systeem waren dergelijke kwantitatieve analyses van eiwitexpressie in weefsels niet mogelijk om uit te voeren. De microscoop opstelling is gepositioneerd in het UMCG Imaging & Microscopy Center (UMIC) zodat het voor alle onderzoekers van UMCG, Rijksuniversiteit Groningen, maar ook daarbuiten [inter)nationaal] toegankelijk is.
Samenvatting van de aanvraag
With the advances in technologies of the last decade, a vast array of knowledge has been generated regarding cell behaviour in different conditions. More recently, it has become clear that microenvironments of cells in organs are essential contributors in creating pertinent niches that control cell (dys)function and pathogenesis of disease. Advances in array-based gene expression - and kinase activity profiling on whole tissue specimens - have significantly contributed to understanding of the cellular pathways involved in cell behaviour in both health and disease. Although data from these array-based studies definitely give clues about the genes and pathways that are active in various conditions, in-depth quantitative analyses at the protein expression level are required to validate array results and to gain insight into the level at which certain molecular pathways are controlled (e.g. at the gene- or at the protein expression level, posttranslational modifications). Generally, such quantitative protein expression studies are performed on whole tissue protein lysates ignoring the cellular context in which cells of interest reside. The TissueFAXS® system allows such quantitative multi-parameter analyses at the single cell level in tissue sections as well as in cultured cells, cell smears and cytospots. As quantitative analysis of protein expression at the single cell level in tissues is as yet not possible within our institution, but is considered an essential tool to strengthen studies employing complex tissues, we here apply for this equipment. The microscope-based TissueFAXS® system is the equivalent to flow cytometry in tissue. Users of the equipment applied for are PIs of research labs within the UMCG whose research is embedded in the research institute GUIDE, with focus on translational, innovative drug-oriented research in which molecular and cellular mechanisms underlying disease and responses to drug treatment are the common denominator. Analyzing protein expression levels quantitatively in tissues at the single cell level using the TissueFAXS® system will provide significant novel information about the control of cell dysfunction at the molecular level and the basis of success (and failure) of conventional as well as new classes of smart drugs, and will be of essential added value for local, national as well as international collaborative studies of the team of applicants.