Genetic and environmental factors predicting the autonomic and vascular effecte of adenosine.
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Titel: Ischaemic preconditioning: from molecular characterisation to clinical application--part I
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: Netherlands Journal of Medicine
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: Netherlands Journal of Medicine
Titel: Effect of the 34C>T variant in the AMPD1 gene on the clinical response to methotrexate in patients with rheumatoid arthritis: comment on the article by Wessels et al
Auteur: Riksen,N.P.; Rongen,G.A.; Smits,P.; van,Riel P.; Barrera,P.
Magazine: Arthritis Rheumatism
Auteur: Riksen,N.P.; Rongen,G.A.; Smits,P.; van,Riel P.; Barrera,P.
Magazine: Arthritis Rheumatism
Titel: Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.
Auteur: Rongen GA, Oyen WJ, Ramakers BP, Riksen NP, Boerman OC, Steinmetz N, Smits P.
Magazine: Circulation
Auteur: Rongen GA, Oyen WJ, Ramakers BP, Riksen NP, Boerman OC, Steinmetz N, Smits P.
Magazine: Circulation
Titel: H19 DMD methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients
Auteur: Heil SG, Riksen NP, Boers GH, Blom HJ
Magazine: Molecular Genetics and Metabolism
Auteur: Heil SG, Riksen NP, Boers GH, Blom HJ
Magazine: Molecular Genetics and Metabolism
Titel: Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations
Auteur: Ramakers BP, Pickkers P, Deussen A, Rongen G, van den Broek P, van der Hoeven JH, Smits P, Riksen NP.
Auteur: Ramakers BP, Pickkers P, Deussen A, Rongen G, van den Broek P, van der Hoeven JH, Smits P, Riksen NP.
Titel: Caffeine prevents protection in two human models of ischemic preconditioning.
Auteur: Riksen NP, Zhou Z, Oyen WJ, Jaspers R, Ramakers BP, Brouwer RM, Boerman OC, Steinmetz N, Smits P, Rongen GA.
Magazine: Journal of American College of Cardiology
Auteur: Riksen NP, Zhou Z, Oyen WJ, Jaspers R, Ramakers BP, Brouwer RM, Boerman OC, Steinmetz N, Smits P, Rongen GA.
Magazine: Journal of American College of Cardiology
Titel: Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene
Auteur: Riksen,N.P.; Franke,B.; Oyen,W.J.; Borm,G.F.; van den,Broek P.; Boerman,O.C.; Smits,P.; Rongen,G.A.
Magazine: European Heart Journal
Auteur: Riksen,N.P.; Franke,B.; Oyen,W.J.; Borm,G.F.; van den,Broek P.; Boerman,O.C.; Smits,P.; Rongen,G.A.
Magazine: European Heart Journal
Titel: In vivo evidence against a role for adenosine in the exercise pressor reflex in humans
Auteur: Riksen,N.P.; van Ginneken,E.E.; van den Broek,P.H.; Smits,P.; Rongen,G.A.
Magazine: Journal of Applied Physiology
Auteur: Riksen,N.P.; van Ginneken,E.E.; van den Broek,P.H.; Smits,P.; Rongen,G.A.
Magazine: Journal of Applied Physiology
Titel: Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans
Auteur: Riksen,N.P.; Oyen,W.J.; Ramakers,B.P.; van den Broek,P.H.; Engbersen,R.; Boerman,O.C.; Smits,P.; Rongen,G.A.
Magazine: Clinical Pharmacology and Therapeutics
Auteur: Riksen,N.P.; Oyen,W.J.; Ramakers,B.P.; van den Broek,P.H.; Engbersen,R.; Boerman,O.C.; Smits,P.; Rongen,G.A.
Magazine: Clinical Pharmacology and Therapeutics
Titel: The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo.
Auteur: Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA.
Magazine: Pharmacogenetics and Genomics
Auteur: Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA.
Magazine: Pharmacogenetics and Genomics
Titel: Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia
Auteur: Riksen,N.P.; Rongen,G.A.; Blom,H.J.; Boers,G.H.; Smits,P.
Magazine: Clinical Chemistry and Laboratory Medicine
Auteur: Riksen,N.P.; Rongen,G.A.; Blom,H.J.; Boers,G.H.; Smits,P.
Magazine: Clinical Chemistry and Laboratory Medicine
Titel: Acute elevation of plasma non-esterified fatty acids increases pulse wave velocity and induces peripheral vasodilation in humans in vivo
Auteur: Riksen,N.P.; Bosselaar,M.; Bakker,S.J.; Heine,R.J.; Rongen,G.A.; Tack,C.J.; Smits,P.
Magazine: Clinical Science
Auteur: Riksen,N.P.; Bosselaar,M.; Bakker,S.J.; Heine,R.J.; Rongen,G.A.; Tack,C.J.; Smits,P.
Magazine: Clinical Science
Titel: The effect of adenosine receptor stimulation on cytokine release by human mononuclear cells is dependent on the specific Toll-like receptor subtype used for stimulation
Auteur: Ramakers BP Riksen NP Rongen GA van der Hoeven JG Smits P Pickkers P
Magazine: Cytokine
Auteur: Ramakers BP Riksen NP Rongen GA van der Hoeven JG Smits P Pickkers P
Magazine: Cytokine
Titel: Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia.
Auteur: Riksen NP, Rongen GA, Boers GH, Blom HJ, van den Broek PH, Smits P.
Magazine: Atherosclerosis Thrombosis and Vascular Biology
Auteur: Riksen NP, Rongen GA, Boers GH, Blom HJ, van den Broek PH, Smits P.
Magazine: Atherosclerosis Thrombosis and Vascular Biology
Titel: Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia
Auteur: Riksen,N.P.; Rongen,G.A.; Blom,H.J.; Russel,F.G.; Boers,G.H.; Smits,P.
Magazine: Cardiovascular Research
Auteur: Riksen,N.P.; Rongen,G.A.; Blom,H.J.; Russel,F.G.; Boers,G.H.; Smits,P.
Magazine: Cardiovascular Research
Titel: Methotrexate modulates the kinetics of adenosine in humans in vivo.
Auteur: Riksen NP, Barrera P, van den Broek PH, van Riel PL, Smits P, Rongen GA.
Magazine: Annals of Rheumatic Diseases
Auteur: Riksen NP, Barrera P, van den Broek PH, van Riel PL, Smits P, Rongen GA.
Magazine: Annals of Rheumatic Diseases
Titel: Ischaemic preconditioning: from molecular characterisation to clinical application--part II
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: Netherlands Journal of Medicine
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: Netherlands Journal of Medicine
Titel: The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: American Heart Journal
Auteur: Riksen,N.P.; Smits,P.; Rongen,G.A.
Magazine: American Heart Journal
Titel: Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations
Auteur: Ramakers BP, Pickkers P, Deussen A, Rongen GA, van den Broek P, van der Hoeven JG, Smits P, Riksen NP.
Magazine: Current Drug Metabolism
Auteur: Ramakers BP, Pickkers P, Deussen A, Rongen GA, van den Broek P, van der Hoeven JG, Smits P, Riksen NP.
Magazine: Current Drug Metabolism
Titel: Adenosine in health and disease
Auteur: NP Riksen
Auteur: NP Riksen
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Background: Interstitial adenosine, as released during ischemia, triggers and mediates powerfull protective mechanisms against ischemia. Four specific adenosine receptors are known: A1, A2a, A2b and A3. Stimulation of A1 receptors induces ischemic preconditioning, inhibits sympathetic influence on the heart, and prevents ischemia-induced arrhythmias. Stimulation of A2 receptors reduces inflammation and thrombocyte aggregation, and relaxes vascular smooth muscle cells. These effects of adenosine act in concert to increase the tolerance to ischemia. In previous research, we have observed substantial inter-individual variation in the response to adenosine administration. This variation may be one of the determinants of the individual risk for cardiovascular complications. Therefore, it is important to investigate possible sources of variation in the response to adenosine. Interstitial adenosine concentration is subject to regulation, can be modulated pharmacologically .Genetic polymorphisms in A1, A2a and A3 receptors have been described. Hypothesis: Inter-individual variation in the response to adenosine is determined by differences in adenosine kinetics and genetic polymorphism in adenosine receptors Study objectives: To relate inter-individual variation in adenosine kinetics and genetic make-up of the adenosine receptor system to hemodynamic and autonomic actions of adenosine. Methods: In healthy volunteers, the adenosine receptor genes will be analyzed for the presence of known polymorphisms. The hemodynamic and autonomic response to adenosine and specific A1 and A2a receptor agonists will be determined. In separate experiments, interstitial adenosine concentrations will be measured in physiological and pathological conditions and in response to several pharmacological interventions on adenosine kinetics (formation, uptake and metabolism) using a microdialysis probe that will be inserted into a forearm muscle. Expected results: Understanding of inter-individual variation in responses to adenosine in terms of adenosine receptor polymorphism and variation in adenosine kinetics. This knowledge will help us to identify patients who are at increased risk for ischemic injury when organ perfusion is jeopardized.