More Knowledge with Fewer Animals consists of several modules. Each module has its own goals, terms and conditions, potential partners and calls for proposals. All the projects awarded grants in each module can be found under the projects tab (link naar projects).
The Application of Innovations module focuses on the application of innovative methods based on human material (so without the use of animal testing) in the field of human disease. Innovative methods/techniques should directly contributed to animal-free research such as organ-on-chip models, 3D tissue engineering, organoid cultures, stem cell and other cell technologies, omics and systems biology.
The Civic Partners module is designed to get civic organisations involved in research into alternatives to animal testing. Potential partners are offered the opportunity to help fund projects and to jointly communicate on alternatives to animal testing.
Thirteen projects have been funded under this module in three rounds (2015, 2016 and 2017), six of them with 50% funding from the Dutch Society for Replacement of Animal Testing. As well as civic partners like the Heart Foundation, the Nederlandse Brandwonden Stichting (Dutch Burns Foundation) and the Maag Lever Darm Stichting (Stomach, Liver, Intestinal Disease Foundation), private parties have also made financial and substantive contributions to several projects.
The Non-animal Testing Techniques module emphasises the development and application of replacement methodologies, with a focus on changing the ‘mindset’. The goal is not so much the replacement as the avoidance of animal testing. This can be enabled by expanding our knowledge of the human system. Twelve projects were launched in this module in 2012.
The ASAT Foundation and the Dutch Society for Replacement of Animal Testing is conducting a feasibility study (the Chembridge project) that is being cofunded by the MKMD programme. In this study, scientists are researching the assessment of cancer risk from exposure to products (collections of substances) in humans. Insight into the mechanistic routes for the onset of cancer and the use of concentrations of substances in daily practice, or lower concentration (actual exposure) should lead to robust evidence on which to assess risks to humans. Work on the project commenced in March 2017.
The Life Sciences & Health (LSH) module focuses on the issues that parties from society and industry encounter in the transition to innovations free of animal testing. Scientists and public and private parties work together on the projects, researching and implementing solutions. Three public-private consortiums have now completed their projects on innovations not tested on animals for the development of medicines for human use. These projects helped progress towards the goals of the Life Sciences & Health Top Sector.
Over the period 2018-2020 ZonMw is developing Create2Solve, a programme for public-private partnership with industry and business focusing on the questions of the private partners. More information on Create2Solve can be found here. (link naar apart tabblad)
The Knowledge Infrastructure module was set up to promote the synthesis of evidence for experimental research based on animal testing and the open access publishing of solid negative or neutral results based on animal testing. Funding is also available in this module for an in-house systematic review workshop and for building and expanding networks. Consortiums wanting to submit a grant application for innovations not tested on animals to a large grant platform like NWA or the EU may apply for this incentive grant. See the ZonMw grants calendar for the latest information on the various calls in this module.
In the period 2018-2020 the Knowledge Infrastructure module will again offer opportunities for:
1. encouraging the publication of negative results in which animal testing has been used;
2. in-house synthesis of evidence workshop for research based on animal testing;
3. practice in synthesis of evidence, whereby researchers perform a synthesis themselves;
4. network grants for the knowledge infrastructure on innovations not tested on animals;
5. incentive grant 2018 (2019 subject to approval).