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Local control of innate lymphoid cell activation by natural cytotoxicity receptors

Projectomschrijving

Our intestines are continuously harmed by external stimuli, i.e. food and bacteria. Specialised cells in the immune system, named innate lymphoid cells (ILC), are normally present to combat invading pathogens. These cells are key to keeping our intestinal barrier healthy. However, it is currently unknown how and when these cells become locally activated to initiate a program leading to the repair of the damaged intestinal cell wall.

Producten

Titel: Human ILC function is inluenced by context-dependent environmental cues
Auteur: Ferry Cornelissen, Yotam E. Bar-Ephraim, Tanja Konijn, Natalie Papazian, Remco M. Hoogenboezem, Mathijs A. Sanders, Reina E. Mebius and Tom Cupedo
Link: http://events.embo.org/16-lymphoid/
Titel: Human ILC3 function is influenced by context-dependent environmental cues
Auteur: Ferry Cornelissen, Yotam E. Bar-Ephraim, Tanja Konijn, Natalie Papazian, Remco M. Hoogenboezem, Mathijs A. Sanders, Reina E. Mebius and Tom Cupedo
Link: http://bsicongress.com/
Titel: Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage
Auteur: Aparicio-Domingo, Patricia, Romera-Hernandez, Monica, Karrich, Julien J., Cornelissen, Ferry, Papazian, Natalie, Lindenbergh-Kortleve, Dicky J., Butler, James A., Boon, Louis, Coles, Mark C., Samsom, Janneke N., Cupedo, Tom
Magazine: Journal of Experimental Medicine
Titel: Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation
Auteur: Bar-Ephraim, Yotam E., Cornelissen, Ferry, Papazian, Natalie, Konijn, Tanja, Hoogenboezem, Remco M., Sanders, Mathijs A., Westerman, Bart A., Gönültas, Mehmet, Kwekkeboom, Jaap, Den Haan, Joke M.M., Reijmers, Rogier M., Mebius, Reina E., Cupedo, Tom
Magazine: Cell

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Samenvatting van de aanvraag

Our intestines are continuously harmed by external stimuli, i.e. food and bacteria. Specialised cells in the immune system, named innate lymphoid cells (ILC), are normally present to combat invading pathogens. These cells are key to keeping our intestinal barrier healthy. However, it is currently unknown how and when these cells become locally activated to initiate a program leading to the repair of the damaged intestinal cell wall.

Onderwerpen

Kenmerken

Projectnummer:
91615128
Looptijd: 100%
Looptijd: 100 %
2014
2018
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Dr. ir. F.H.J. Cornelissen
Verantwoordelijke organisatie:
Erasmus MC