• Cell mechanism:

    • Efflux pump inhibition or cell membrane destabilization in Mycobacterium tuberculosis to enhance the activity of TB drugs and prevent drug resistance.
      (Radboud University Nijmegen, The Netherlands; Priority Medicines Antimicrobiële Resistentie-project 205200002; completed in March 2018)
    • The tuberculosis bacilli have holes in their armor. The TBC bacilli have a remarkable impermeable cell wall that prevents most antibiotics from gaining access to the cell. However, the shield can not be completely impenetrable; the bacteria must also acquire nutrition. In this Veni project, the researchers investigate essential transport proteins. They are possibly forming the Achilles heel of these bacilli.
      (Dr. A. Speer, Free University Medical Centre (VUMC, the Netherlands);  Veni-project NWO-ALW; expected 2020)
  • Antibiotic resistance:

    • Protecting Pyrazinamide (PZA) and fluoroquinolones (FLQ) for successful multi drug resistant tuberculosis (MDR-TB) treatment
      (RIVM, the Netherlands; AntibioticaResistentie-project 541002006; verwachte einddatum September 2020)
    • Selection of appropriate treatment and infection control measures by integrated high throughput genotyping and drug resistance determination of M. tuberculosis clinical isolates
      (Royal Tropical Institute, the Netherlands; Priority Medicines Antimicrobiële Resistentie-project 205100005; completed 2015)
    • The tuberculosis bacilli store fats from the host as fat globules. Why this happens is unknown. However, the presence of such fat globules is associated with antibiotic resistance, a major problem in the fight against tuberculosis. In this Veni project, the formation and role of these fat globules is investigated.
      (Dr. S. Commandeur, Free University Medical Centre (VUMC, the Netherlands); Veni-project NWO ALW; expected 2020)
  • Screening immigrants:

  • Co-evolution:

    • Unravelling the relationship of innate immunity and bacterial genotype, and its relevance for disease phenotype will provide new insights in host-pathogen interplay in TB. This will impact our understanding of the worldwide emergence of new, and often more successful M. tuberculosis strains, and will help develop better tools for management of TB.
      (Radboud University Nijmegen; Vidi-project 91710310; completed 2015)
To top
Direct naar: InhoudSkip to navigationSkip to website footer