On behalf of the Netherlands, we are part of the international partnership Joint Programming Initiative on Antimicrobial Resistance (JPIAMR), currently a collaboration between 28 member countries. Many projects funded under the framework of the JPIAMR already resulted in outstanding publications that range over One Health areas (Human, Animal, Environment). Here we highlight three projects.

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These projects are co-funded by ZonMw, with Dutch coordinators and/or project partners that recently published their results. Below are the summaries of the highlighted publications across the priority topics of the JPIAMR Strategic Research and Innovation Agenda (SRIA).

WGS snapshot of MDR Klebsiella pneumoniae strains from WWTPs

A publication in PlosOne, 2020 from the project AWARE reported genomic characterization of 47 multi-drug resistant, carbapenem resistant and ESBL-producing Klebsiella pneumoniae isolates from hospitals and receiving wastewater treatment plants (WWTPs) in Southern Romania. The presented results enrich the knowledge of the epidemiological context of ESKAPE pathogens at national and European level, a major step in the implementation of reliable surveillance and actions plans.

Priority topic SRIA: Environment
Call on Transmission Dynamics, 2016
Consortium coordinator: Ana Maria de Roda Husman, Centre Infectious Disease Control, RIVM, Netherlands.
Including partners from: Netherlands, Sweden, Romania, Germany, Australia, Switzerland
Involved funders: ZonMw, SRC/FORMAS, ANCSI, BMBF/DLR
 

A digital antimicrobial stewardship smartphone application

AB-Assistant published a study protocol to evaluate the impact of digital antimicrobial stewardship smartphone application on quantity and quality of antimicrobial drug prescribing for the hospital setting in BMJ Open, 2020. This study is now registered for an international randomised, multicentre, clinical trial. (Trial registration number: NCT03793946, ClinicalTrials.gov registry).

Priority topic SRIA: Interventions
Call on Prevention and Intervention strategies to Control AMR infections, 2017
Consortium coordinator: Annelies Verbon, Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Netherlands.
Including partners from: Netherlands, Sweden, Switzerland, Canada, Romania, Czech Republic
Involved funders: ZonMw, SRC, SNSF, CIHR

COM-Blockers reduce the spread of virulence factors and antibiotic resistance

The project COMBINATORIALS published an article in Cell Host & Microbe, 2020 where they identified potent competence inhibitors in Streptococcus pneumoniae, called COM-blockers. These compounds disrupt proton motive force, block natural competence (COM) and interrupt intraspecies horizontal gene transfer and exchange of antibiotic resistance. Such strategies might minimize clinical spread of antibiotic resistance.

Priority topic SRIA: Therapeutics
Antimicrobial Resistance through the JPIAMR, 2015
Consortium coordinator: Typas Athanasios, European Molecular Biology Laboratory, Genome Biology Unit, Germany.
Dutch project partner: Jan-Willem Veening, Molecular Genetics Department, University of Groningen
Including partners from: Germany, Netherlands, France, Sweden
Involved funders: DRL, ZonMw, ANR, SCR
 
The entire list of the publications from the projects and networks supported under the JPIAMR framework is also available on the webpage: www.jpiamr.eu/scientific-articles

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