The Belgian Health Care Knowledge Centre (KCE) and ZonMw invest a maximum of 9 million euros in the second round of their joint programme ‘BeNeFIT’.


  • Comparative effectiveness trials
  • Practice-oriented clinical studies
  • Efficiency Studies
  • Return on investment

Part of programme

Health care efficiency research & Rational Pharmacotherapy

Published on

3 June 2021


9 September 2021,

Read the complete grant call

Do you want to apply? The entire grant call can be accessed using the link below. Here you can find all the specific information about the call.

Belgium-Netherlands Funding of International Trials (pdf) 389 KB

Purpose of call

The aim of the call is to provide funding for clinical trials that compare the effectiveness of existing health care interventions that are already in use in a given indication, e.g. comparisons between two medications, medical therapy versus surgery, trials investigating optimal timing of surgery etc. The research should be pragmatic and practice-oriented. Trials funded within the BeNeFIT program must be of a non-commercial nature. The different treatment options that are compared in a BeNeFIT trial should concern treatments that are (or have the potential of being) reimbursed by health care payers in Belgium and the Netherlands. Moreover, each BeNeFIT trial should have the potential of generating results with an immediate and important impact on the efficiency of the health care systems in Belgium and The Netherlands.

Sums available

For both the budget and duration of the proposed trial, no maximum amount is defined.

  • The proposed budget of the trial must be reasonable and commensurate with the work involved. A thorough evaluation of the proposed budget is part of the total assessment procedure.
  • The duration of the study should be realistic.
  • The available budget for this call is 9 million euros.


The BeNeFIT call focuses on comparative effectiveness trials which show clear value for money and have the potential for return on investment. Accepted trial interventions are not limited to drugs or medical devices but also include a broad range of interventions, such as psychotherapy, diet, diagnostic tests or surgery. Proposals will be selected based on the need for evidence in clinical practice and possible efficiency improvement and potential return on investment for the health care systems. The primary aim of the trial must be of a non-commercial nature.

Eligible candidates

This call is only open for projects who are invited for a full research proposal.

Submit application

You may submit your application via ProjectNet until 09-september-2021, 14.00 CET.

Download all information

The call text can be downloaded as a pdf and contains all detailed information about this call.

Belgium-Netherlands Funding of International Trials (pdf) 389 KB


Please contact us with any questions that are not covered in the FAQs. For general queries, please contact Helene Philippo or Ruud van Zessen. If you have any technical questions about ProjectNet please contact the service desk.

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Helene Philippo

Senior Programme Manager

+31 70 349 54 64
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Ruud van Zessen

Programme Manager

+31 70 349 50 25
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