ZonMw tijdlijn Coronavirus https://www.zonmw.nl/ Het laatste nieuws van de tijdlijn van Coronavirus en-gb Fri, 18 Jun 2021 23:20:57 +0200 Fri, 18 Jun 2021 23:20:57 +0200 TYPO3 news-7109 Fri, 02 Apr 2021 10:29:33 +0200 Start research into the optimal use of COVID-19 vaccines for patients with immune system disorders https://www.zonmw.nl/nl/actueel/nieuws/detail/item/start-research-into-the-optimal-use-of-covid-19-vaccines-for-patients-with-immune-system-disorders/ Research groups will further investigate the effect of COVID-19 vaccines in patients with immune disorders, cancer or a transplantation. These research projects are part of the COVID-19 research programme, and each project has received a grant from ZonMw.
On behalf of the Ministry of Health, Welfare and Sport and in collaboration with the National Institute for Public Health and the Environment (RIVM), ZonMw is focusing in these studies on optimising the effect of COVID-19 vaccination in groups of patients who have an immune system disorder. This includes patients with malignancies, immune disorders and other patient populations not identified in previous studies.

The research to be funded supplements RIVM’s research in the context of monitoring and evaluating national vaccination programmes and also the research carried out by the vaccine manufacturers. The patients will be vaccinated as part of the government’s vaccination strategy against COVID-19. The new research projects will provide knowledge for patients and those treating them, and it will support an optimum use of vaccines in these groups.

Patients with an immune system disorder

The vaccines currently available are mainly, but not limited to, vaccines tested by the manufacturers on relatively healthy adults. Specific risk groups, such as people with certain diseases, obesity, Down’s syndrome, pregnant women and certain age categories (dependent on the maximum age of the people selected for the vaccine study) are only partly included in these studies. The registration authorities have approved the vaccines for these target groups as well. However, additional research into these groups is still needed to provide us with more insights into the immune response to vaccine antigens in patients with a less well-functioning immune system. Such a less well-functioning immune system could be due to birth defect or it could be caused by a transplantation or immune-modulating treatments (chemotherapy, immunotherapy).

Studies will initially focus on patients with autoimmune diseases who are treated with immunosuppressive drugs, patients with primary immune deficiencies or immune disorders, cancer patients (solid tumours) who are treated with chemotherapy and/or immunotherapy, patients with a kidney transplant and dialysis patients, lung transplant patients and people with Down’s syndrome. The RIVM will investigate the immune response in the general population, including the elderly.

Prepared for new pandemics

Within the ZonMw and RIVM projects, standardised protocols and measurement methods are used that have been internationally agreed upon. This means that overarching research across the different vaccines and populations is possible. The knowledge developed through national and international collaboration and analysis will ensure that we are better prepared for the use of vaccines in any possible new pandemics.

More information

•    Read more about research into the coronavirus and COVID-19

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news-6284 Tue, 08 Sep 2020 14:00:00 +0200 COVID-19 funding round for the Caribbean part of the Kingdom of the Netherlands https://www.zonmw.nl/nl/actueel/nieuws/detail/item/covid-19-funding-round-for-the-caribbean-part-of-the-kingdom-of-the-netherlands/ Within the COVID-19 Programme, ZonMw and NWO have opened a funding round that is specifically intended for the Caribbean part of the Kingdom of the Netherlands. Reason for funding round

The coronavirus crisis has had a huge impact on the Caribbean part of the Kingdom. Measures that have been taken worldwide, such as travel restrictions, have led to the loss of tourism to these countries. The considerable dependence on this sector, combined with the small scale of operations in the region, has resulted in many residents no longer having an income. At the lower side of the labour market, in particular, many jobs have been lost. Vulnerable groups in society are the worst-hit.

Solutions through research

There is no simple solution to this complex issue. Research is needed to offer government bodies and residents of the Caribbean part of the Kingdom a way out of this crisis and possible future crises too. How do you ensure that societies and economies become resilient? What works and what does not? The focus is on two subjects:
-    Protecting vulnerable groups in society;
-    Building up a more diverse and accordingly more resilient economy.
As part of the COVID-19 Programme – focus area Societal Dynamics -  this funding round therefore focuses on these two subjects.

Planning and budget

From 8 September 2020 onwards, research proposals can be submitted to ZonMw by the universities of Aruba, Curaçao and St. Martin. A total of € 500,000 is available and applicants can apply for a maximum of € 250,000 per project. The intended maximum duration of the projects is 18 months. The deadline for submitting proposals is 27 October 2020. The projects can start at the end of November.

More information

•    See the call for proposals COVID-19: Societal dynamics in the Dutch Caribbean
•    Read more about current and completed studies into COVID-19
•    Go to the page about the COVID-19 Programme

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news-6091 Mon, 31 Aug 2020 09:43:46 +0200 Open Access: more impact from research https://www.zonmw.nl/nl/actueel/nieuws/detail/item/open-access-more-impact-from-research/ Open Access publishing ensures that research is quickly and easily accessible. During the coronavirus pandemic, the importance of that has become clearer than ever before. For example, doctors and patients search for information about the treatment of COVID-19. To increase the impact of knowledge, ZonMw will tighten the guidelines for Open Access with effect from 1 January 2021. What will change? Better research and more impact through Open Access

Sharing publications and data in a quick and accessible manner (Open Access) helps science, healthcare and education to progress. Doctors, patients, policymakers and professional practitioners can immediately make use of the most recent insights and data. The quality of research and data improves because colleagues can immediately examine the results published and can reproduce experiments in their own lab. It also improves national and international collaboration between researchers. Furthermore, It becomes clear at an earlier stage if something does not work, which means that research can then be adjusted or stopped. For example, it was mainly thanks to Open Access publications that the efficacy and safety of chloroquine and hydroxychloroquine as a treatment for COVID-19 patients was quickly shown to be inadequate. Jeroen Geurts, chair of the board of ZonMw: ‘The coronavirus pandemic has very clearly underlined the importance of Open Access publishing’.

Implementation of Plan S

Since 2013, ZonMw has required researchers to make all publications that emerge from research that is partially or entirely funded by ZonMw available in Open Access form. A study by the Centre for Science and Technology Studies (CWTS) reveals that in 2018 that was already the case for 60% of publications. ZonMw wants to accelerate this positive development. In mid-2019, ZonMw endorsed Plan S for Open Access. This plan has been drawn up by cOAlition S, an international collaboration of research councils, with the aim of realising 100% Open Access. Just like NWO, ZonMw will implement the guidelines from Plan S this year.

Direct 100% Open Access from 1 January 2021 onwards

The principles of Plan S apply to all call proposals that ZonMw publishes with effect from 1 January 2021. Therefore, compared to 2020, ZonMw will further tighten the guidelines. In practice, this means, for example, that there is free access to the publications and no embargo period between the date of publication in a journal and the publication being freely accessible online. Publication will also be under a Creative Commons licence, enabling sharing/reuse of results. Also retainment of copyright by authors or institutes will be aimed for.

Obstacles to overcome

Many researchers already publish in Open Access form but not in all cases and not always directly. The implementation of Plan S will therefore provide researchers from ZonMw projects opportunities but also obstacles that need to be overcome. For example, researchers experience that large sums sometimes have to be paid for Open Access publishing. That problem is currently being worked on, for example through national agreements between universities and publishers. ZonMw will also examine possible solutions to this problem. Rob Diemel, ZonMw coordinator Open Science: ‘ZonMw wants encourage Open Access via several routes so the project leaders can make their own choices. For example, in new funding rounds from 2021 onwards, applicants can include a post in the project budget for publication via the so-called full golden route (publications that are immediately free and accessible for everybody ). We will also facilitate the green route by offering researchers access to a repository that is frequently used worldwide. This will lead to the more rapid spread of research results and will offer researchers greater visibility.’

Open Access to utilise knowledge in society

Even though the transition from publishing behind paywalls to Open Access is a difficult process, Jeroen Geurts also sees that researchers are increasingly embracing Open Access: ‘Of course, researchers also feel the need to allow their findings to be used by society. In the case of COVID-19 research programmes, you can see that there is a considerable amount of expertise in the Netherlands to counteract the medical and non-medical negative effects of COVID-19. Rapid access to each other’s research and being able to make use of each other’s research is vitally important for researchers, especially if they are working in a race against the clock.’

Recognising and rewarding researchers

Open Access also requires a different way of recognising and rewarding researchers. Open Access publications are easy to find, are cited more often and have a greater reach. It is important that researchers are rewarded for the quality of their research and its importance for science and/or society, and not for controversial indicators such as the journal impact factor and H-index. Therefore, from 2021 onwards, the DORA (Declaration on Research Assessment) principles will be used in the assessment and selection of ZonMw funding proposals. Amongst other things, that should lead to another way of recognising and rewarding researchers.

Requiring but also informing and facilitating

During the course of 2020, ZonMw will mainly focus on implementing the guidelines from Plan S and informing and advising researchers and project teams about the Open Access publication of their research. The ZonMw Open Access team will also facilitate this implementation by including the guidelines and the processes and thoroughly preparing ZonMw employees for these changes so that they can help applicants. All of the information can be found on the ZonMw website and, of course, if you have any questions, you can contact the employees of the Open Access team.

More information

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news-6072 Wed, 26 Aug 2020 09:00:00 +0200 Societal effects of COVID-19 examined https://www.zonmw.nl/nl/actueel/nieuws/detail/item/societal-effects-of-covid-19-examined/ 20 new research projects will soon begin to investigate the impact of the coronavirus (COVID-19) on Dutch society. 11 more projects will receive funding after additional administrative steps. These research projects will focus on the impact of the measures taken, the resilience of society, and the economic consequences for society. Thanks to the quick start and short duration of the projects, the studies can provide relevant knowledge in the short term. Effectiveness and impact of measures

Projects that are part of this theme will examine the effectiveness and impact of the measures taken and of the strategies in response to the coronavirus crisis. The projects range from research into the well-being and sustainable deployment of healthcare staff to research into the effect of the measures taken on the constitutional rights of vulnerable plaintiffs in particular, and their confidence in the justice system. Other examples are research into the lessons that we can learn from the measures taken by other European countries, and research into the preferences for introducing COVID-19 apps in the Netherlands.

Human resilience and society

Within this theme, the research mainly focuses on groups who during the coronavirus crisis have been disproportionately affected by the consequences of the measures taken in either the social or societal spheres. For example, research will be done into the educational disadvantage experienced by underprivileged (primary school) pupils and also new vulnerable groups that have arisen (such as sole proprietors and people with a temporary job, including many young people). Furthermore, the mental and physical long-term effects on former COVID-19 patients and healthcare employees will be investigated.

Consequences and solutions for the economy

Research into the economic resilience focuses on the effect of the crisis on various sectors of the economy, the labour market and support measures. For example, one study focuses on strengthening the regional economic structure with the aim of increasing the national economic resilience in the long term. In addition, research will be done into to what extent and in what way sectors in regions are affected by the corona crisis and what explains the differences in resilience and agility of regions.

COVID-19 Programme

More information about the projects will soon be available on the ZonMw website. These research projects are starting in the context of a large action and research programme concerning the new coronavirus that ZonMw set up in collaboration with NWO in May. Research projects into the diagnostics, treatment and prevention of the coronavirus began last month. In addition, more than 50 collaborations have been established within this programme between research institutions and civil society organisations.

More information 

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news-6016 Fri, 07 Aug 2020 13:42:01 +0200 ZonMw’s approach to optimize reuse of COVID-19 related data https://www.zonmw.nl/nl/actueel/nieuws/detail/item/zonmws-approach-to-optimize-reuse-of-covid-19-related-data/ Under the urgency of the outbreak of the corona pandemic, we take a number of actions to enable researchers in ZonMw’s COVID-19 projects to create FAIR data that can be used by humans as well as machines. As a result, data become findable through computer search, and accessible for learning-algorithms (comparable to the Personal Health Train concept). The results of the activities are available for the entire research community of COVID-19. VODAN for COVID-19 patient data

In spring 2020, ZonMw commissioned the GO FAIR initiative and its VODAN (Virus Outbreak Data Access Network) Implementation Network to make COVID-19 related data FAIR.  As a result, real world COVID-19 patient data become available for research, under well-defined conditions and with patient privacy well protected.

In summer 2020, the VODAN project delivered a proof of concept of a working VODAN infrastructure to open up COVID-19 patient data via so called FAIR Data Points: VODAN-in-a box. It is made up of a number of components:

  1. A semantic data model based on the case report form (CRF) following the WHO standards;
  2. Localized VODAN FAIR Data Points (FDP’s), where the (meta)data of the machine-readable eCRF files could be hosted. Several FDP’s have been installed, in the Netherlands, USA and on the African continent (funded by the Philips Foundation).
  3. A user-friendly data-entry-wizard, allowing data stewards in the local clinic or hospital to capture patient data in the CRF.
  4. Creating/updating the metadata on the installed VODAN FDP’s, “link” the patient data and indicate if the data can be shared.
  5. A simple tool to allow queries to “visit” the (meta) data across multiple FDP’s, thereby performing analysis based upon certain characteristics of the recorded patients.

FAIR data services and a national COVID-19 data portal

As a next step, building on the knowledge and deliverables from VODAN, ZonMw has commissioned the GO FAIR Foundation and the Health-RI Foundation to develop FAIR data services and a national COVID-19 data portal. These services will support researchers in the creation of FAIR research outputs, and to find and reuse COVID-19 related observational data from Dutch health care providers (taking privacy and other ethical, legal and social issues in to account).

An advanced approach for creating FAIR data

The FAIR data services will function as a three-point FAIRification Framework, where FAIR metadata are crafted for each project (1) as part of the overall COVID-19 Programme FAIR Implementation Profile (2) which then configures the FAIR Data Point (3) where COVID-19 Programme research outputs can be easily discovered and reused. The planned national COVID-19 data portal will form a human friendly interface to the metadata and observational hospital data.

Data experts collaborate with domain experts

A crucial aspect of the FAIRification approach is that domain experts collaborate with data experts in order to include the standards, technologies and infrastructure that match the research community, in this case COVID-19. We will therefore facilitate that COVID-19 researchers and data stewards from ZonMw projects make use of the three-point FAIRification Framework, with the support of the FAIR data experts from GO FAIR and Health-RI.

Workshops and training

Researchers and data stewards from ZonMw’s COVID-19 projects are invited for a workshop series in autumn 2020 for an introduction to the FAIRification framework, and to take part in tailoring the framework to the needs of the COVID-19 research community.
In addition, data stewards from the ZonMw projects will be trained by and get support from the FAIR data experts of GO FAIR and Health-RI. Support through the data steward community will be organised within the Data Stewardship Special Interest Group (DSIG).

Taken together, by taking part in these activities, researchers and data stewards create – as a minimum - FAIR metadata for their research data. They thereby allow other research on COVID-19 to directly benefit from their activities, and accelerate solutions for the corona crisis. In a broader sense, they contribute to a growing knowledge base on FAIR data, enabling innovative research methods.

More information

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news-5961 Tue, 21 Jul 2020 12:27:58 +0200 Innovative research awarded funding in COVID-19 Programme https://www.zonmw.nl/nl/actueel/nieuws/detail/item/innovative-research-awarded-funding-in-covid-19-programme/ Within the COVID-19 Programme, a total of 40 projects have now been awarded funding. In addition, 12 more projects will receive funding after additional administrative steps. In this programme, research will start that focuses on the effects of the measures against the coronavirus pandemic. This concerns a substantial financial injection in the Dutch research field. With this funding, the Ministry of Health, Welfare and Sport, together with ZonMw and the Dutch Research Council (NWO), is focusing on the rapid introduction of innovative measures that emerge from these projects. Research across the full breadth of healthcare

An effective approach to the coronavirus pandemic is associated with many knowledge requirements and research questions. The COVID-19 Programme has three focus areas:

  • Predictive diagnostics and treatment
  • Care and prevention
  • Societal dynamics

Predictive diagnostics and treatment

Within focus area 1, “Predictive diagnostics and treatment”, 17 of the 22 eligible projects were awarded funding. Several of these projects focus on new or existing therapies and their modes of action. Other projects focus, for example, on acquiring insights into the microbiome, immunity, predictive parameters and individualised treatments.
An example of such a project is: A phase 2 clinical study necessary for the clinical development of the drug lanadelumab against COVID-19 from Dr R. Brüggemann and Dr F. van de Veerdonk from Radboudumc. In this project, it will be investigated whether the intravenous administration of lanadelumab can prevent and reduce the need for the external administration of oxygen – necessary due to lung oedema – during the COVID-19 infection.

Animal-free innovations

Besides the 22 projects stated, 5 projects within focus area 1 will do research into the development of new or broader applications of existing animal-free innovations. The ZonMw programme “More Knowledge with Fewer Animals” and the Dutch Society for Replacement of Animal Testing made more than 2 million euros available for this. The ultimate aim is more relevant health and healthcare research for people.

Care and prevention

Within focus area 2, “Care and prevention”, 20 of the 25 eligible projects were awarded funding. These projects focus on the organisation of care and vulnerable citizens. In addition, there is specific attention for care providers. The focus is on:

  • The impact of behaviour and behavioural changes on the spread of the virus
  • The consequences of the measures for the individual or the specific vulnerable groups
  • Spread of the epidemic and measures to prevent this

For example, there is the project “TRACE II: Patient outcomes after postponed elective operations during the COVID-19 pandemic” from Dr D. de Korte-de Boer and Prof. Wolfgang Buhre (Department of Anaesthesiology and Pain Medicine at Maastricht University Medical Center+). In this project, the effect of postponing non-acute operations during the COVID-19 pandemic will be investigated by a consortium of 10 institutions, including 4 university hospitals and 5 peripheral hospitals.

Palliative care

Within focus area 2, five projects in the programme “Palliantie. More than care” are eligible for funding. Three of those have now been awarded funding. The projects focus on support and grief counselling for the family and friends of people who have died. There is also attention for the impact of social isolation due to COVID-19 on intra- and extramural care for people with dementia in the palliative phase.

Duration and budget

The COVID-19 Programme has been funded by the Ministry of Health, Welfare and Sport, the Ministry of Education, Culture and Science and NWO. For this action and research programme a total of 40 million euros has been made available for grants for practice and research projects. At the end of August, the granting decision will be taken for the proposals from focus area 3 “Societal dynamics”. All projects will start in September 2020.

Exceptional situation

The coronavirus crisis has had a considerable impact, also on public health and healthcare. There is a huge demand for new knowledge and practical solutions to limit the negative consequences of the pandemic. Research is needed to learn from the negative and positive experiences, both now and in the longer term. Therefore, on behalf of the Ministry of Education, Culture and Science, and in collaboration with NWO, we prepared an action and research programme in March 2020 that, amongst other things, resulted in the COVID-19 Programme. The speed with which this was realised was an enormous challenge for the grant applicants, NWO and us.

More information

 

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news-5744 Fri, 29 May 2020 14:33:32 +0200 Update COVID-19 Programme: many applications https://www.zonmw.nl/nl/actueel/nieuws/detail/item/update-covid-19-programme-many-applications/ The interest for our calls for proposals within the COVID-19 Programme is considerable. In the past few weeks, we were pleased to receive many applications. In this update, you can read about the current state of affairs and the planning for the coming period. The COVID-19 Programme is a collaboration between ZonMw and NWO, and funds research that focuses on the effects of the coronavirus crisis and the measures taken against the coronavirus pandemic. Knowledge, practical solutions and research are urgently needed because limiting the negative consequences of the pandemic is a top priority.

Considerable interest

The funding rounds of the three focus areas yielded a lot of project ideas. We received 120 grant applications for the funding possibility Science for professional practice.

  • From 1 to 14 May, the bottom-up funding round was open for the submission of project ideas for focus area 1, Predictive diagnostics and treatment, and focus area 2, Care and prevention. We received 189 project ideas for focus area 1 and 306 for focus area 2
  • From 8 to 25 May, the bottom-up funding round for focus area 3 Societal dynamics was open. We received 508 project ideas for this
  • From 8 to 25 May, the funding round Science for professional practice was also open. A total of 120 research proposals were received for this

Granting Urgent Research Questions

Previously research groups were invited for the route Urgent research questions. From this route two proposals for focus area 1, Predictive diagnostics and treatment have provisionally been assessed and selected for granting. Two other proposals for focus area 2, Care and prevention also have been granted. At this moment three proposals for urgent research questions are being worked out in a full proposal for focus area 3, Societal dynamics and will be assessed soon.

Planning

The next step for the three focus areas is the assessment of the proposals by the committees. If the committee issues a positive advice, then the applicants will receive an invitation to elaborate their project idea into a research proposal. At that moment, FAQs about this will be published on our website.
The selection procedure for the research proposals for Science for professional practice will start shortly.

The most up-to-date information about the process and the planning can be found on the various programme pages (only in Dutch):

  • Focus area 1: Predictive diagnostics and treatment
  • Focus area 2: Care and prevention
  • Focus area 3: Societal dynamics
  • Science for professional practice

More information

 

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news-5667 Thu, 07 May 2020 12:03:00 +0200 COVID-19 Programme call for proposals “Societal dynamics” now open https://www.zonmw.nl/nl/actueel/nieuws/detail/item/covid-19-programme-call-for-proposals-societal-dynamics-now-open/ The call for proposals for the focus area “Societal dynamics” within the COVID-19 Programme is now open. Consortia, research groups and independent researchers from several disciplines can submit ideas for research aimed at the societal effects of the coronavirus pandemic and of the (intended) measures against it. Given the need to act urgently, the deadline for submitting ideas is 25 May 2020, at 14.00 hours. The COVID-19 Programme

The action and research programme COVID-19 focuses on research aimed at the effects of the coronavirus pandemic and the measures taken against it. There are three focus areas:
1.    Predictive diagnostics and treatment
2.    Care and prevention
3.    Societal dynamics

This call for proposals concerns only focus area 3 “Societal dynamics”, and the total budget available for grants is €6.5 million. The call for proposals for focus areas 1 and 2 was published on 1 May 2020 and has a deadline of 14 May 2020 at 14.00 hours. Further information about this call can be read here (will soon be available in English).

Focus area societal dynamics

The focus area “Societal dynamics” concerns broad, societal issues in which several scientific disciplines are involved. For example, it concerns answers to questions such as: What are the societal consequences of the coronavirus crisis? Which social and economic problems have been exposed or have arisen as a result of this? But also: which positive effects does the crisis have? Which restart scenarios exist after a shorter or longer period of economic and widespread societal disruption? What can we learn from the crisis for the future?

Invitation to submit research ideas

With this call for proposals, consortia, research groups and individual researchers are invited to submit ideas for research projects to generate knowledge about the Dutch and worldwide impact of the coronavirus crisis and the measures taken against this. The research focuses not just on the challenges during this pandemic but also on the situation after the coronavirus crisis. Furthermore, the research relates to the priority themes described below.

Priority themes

A multidisciplinary expert panel chaired by Jet Bussemaker (former Minister for Education, Culture and Science) has put forward the following priority themes for which proposals on the associated subjects can be submitted:
1    Research into the effectiveness and impact of measures/strategies in response to the coronavirus crisis
Subjects: reliability and legitimacy of the government and science during a crisis, the conditions for technologies, linked to the “opening” of society, the effects of the 1.5 m measure, differences between European countries.
2    Research into the resilience of society
Subjects: vulnerable groups, social inequalities as a result of the measures taken, home education, psychological effects and emotional well-being, citizen initiatives.
3    Research into the economic resilience
Subjects: the economic effects of the lockdown for different sectors, reopening sectors of the economy, working from home.

These things need to be investigated with the highest urgency. Project ideas must relate to one or more of these themes. The themes and subjects are explained in greater detail in the call text.

Planning funding round

The following timetable applies to this funding round:

Deadline submission project idea 25 May 2020, 14.00 hours (CEST)
Receipt advice from the committee Around 18 June 2020
Deadline submission full proposal 29 June, 14.00 hours (CEST)
Receipt comments from referees 6 July 2020
Deadline submission rebuttal 8 July 2020, 12.00 hours (CEST)
Decision Around 23 July 2020
Latest starting date 3 August 2020

The English version of the call for proposals will be published on the ZonMw website shortly.

More information

 

 

 

 

 

 

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news-5648 Fri, 01 May 2020 16:40:44 +0200 Call for proposals COVID-19 Programme (‘second wave’) open for project ideas https://www.zonmw.nl/nl/actueel/nieuws/detail/item/call-for-proposals-covid-19-programme-second-wave-open-for-project-ideas/ The call for proposals for two focus areas within the COVID-19 Programme has now been published. Research groups can submit proposals for research aimed at the effects of the coronavirus pandemic and the measures taken against it. In view of the need to act urgently, the deadline has been set at 14 May 2020. Three focus areas

The programme has three focus areas:

  1. Predictive diagnostics and treatment
  2. Care and prevention
  3. Societal dynamics

The call for proposals concerns the first two focus areas.

Focus area 1: Predictive diagnostics and treatment

Research in this focus area concerns the (further) development of (predictive) diagnostics for individualised treatment and for the prevention of COVID-19-related symptoms in the early, acute and recovery phases. It concerns research that is urgently needed into new or existing therapies and their modes of action, and on obtaining insight into, amongst other things, the microbiome, immunity, predictive parameters and individualised treatment.

The focus area has four themes:

  1. Treatment
  2. Diagnostics of infection
  3. Risk analysis and prognostics
  4. Virus, immunity, immune response and pathogenesis

Focus area 2: Care and prevention

The emphasis within this focus area lies on obtaining insights and lessons learned that contribute to an improved, substantiated response towards the current pandemic, and the safeguarding of these improved approaches and processes in the care system of the future. Various types of research are possible: evaluation pathways, action research, effect studies, facilitation pathways, efficacy research in the case of postponement of treatment/avoidance of care, organisation of care issues, development of epidemiological models, and inventories.
To achieve this, collaboration between research groups, disciplines and relevant stakeholders is the starting point for obtaining these insights in an efficient manner and for realising an adequate preparation for a future pandemic.

The focus area has three themes:

  1. Organisation of care and prevention
  2. Care and prevention for vulnerable citizens
  3. Transmission and epidemiology

Focus area 3 and policy and professional practice boosts:

The call for proposals for focus area 3 Societal dynamics and the funding instrument policy and professional practice boosts will be published on 6 May 2020. Therefore keep an eye on the ZonMw grant calendar (open calls for proposals).

Planning
The following timetable applies to the funding round for focus areas 1 and 2:

Deadline submission project idea
Receipt advice selection committee
Deadline submission full proposal
Receipt comments from referees
Deadline submission rebuttal
Decision
Latest starting date

14 May 2020, 14.00 hours
Around 5 June 2020
15 June 2020, 14.00 hours
22 June 2020
24 June 2020, 12.00 hours
Around 9 July 2020
30 July 2020

 

More information

 

 

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news-5616 Sat, 25 Apr 2020 11:56:32 +0200 Details COVID-19 research programme (“second wave”) now online https://www.zonmw.nl/nl/actueel/nieuws/detail/item/details-covid-19-research-programme-second-wave-now-online/ Today we published the COVID-19 research programme (“second wave”). The programme has three focus areas:

  1. Predictive diagnostics and treatment
  2. Care and prevention
  3. Societal dynamics

For each focus area, an expert panel will prioritise the research subjects in a very short space of time. The composition of these expert panels will be published next week on the programme page of ZonMw. Once the expert panels have determined the research subjects, the focus areas in the calls for proposals will be elaborated. The programme has three funding possibilities: urgent research questions track, bottom-up funding track and policy and professional practice boosts track. Within the urgent research questions track, the projects must be assessed and started very quickly. That requires a strongly abridged procedure. For this track, ZonMw will invite research groups to submit a proposal. The bottom-up funding track will be open for a short time (two weeks) for the submission of project ideas within the themes prioritised by the expert panel. This track will also use an accelerated procedure. For the policy and professional practice boosts, the programme has a budget for small projects and studies up to a maximum of €25,000. How this track will be given form has yet to be determined.
Further information about focus areas and the funding instruments can be found in the programme text.

Timetable

The current timetable is given below. For the most recent timetable, please see the programme page.

  • We will shortly invite the research groups for the urgent research questions track. The first grants within this track will be announced in mid-May.
  • The call for proposals for the bottom-up funding track focus areas 1 and 2 will be published on the ZonMw and NWO grant calendars no later than 1 May.
  • On 6 May, we will publish the call for proposals for the bottom-up funding track focus area 3 and for the policy and professional practice boosts on the ZonMw and NWO websites.
  • It is expected that the first projects from the bottom-up funding track will be granted at the end of June/start of July.

More information

(all the information will be available in English before 1 May)

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news-5590 Mon, 20 Apr 2020 11:35:04 +0200 Start research programme COVID-19 (“second wave”) https://www.zonmw.nl/nl/actueel/nieuws/detail/item/start-research-programme-covid-19-second-wave/ Due to the considerable impact of the coronavirus crisis, there is a major need for medical and societal solutions and answers. Therefore, ZonMw, on behalf of the Ministry of Health, Welfare and Sport, will shortly start the research programme COVID-19. This will be realised in collaboration with the Dutch Research Council (NWO) and as a follow-up to the “first wave”. The aim of this programme is to contribute to controlling the consequences of the coronavirus (COVID-19) in the short and long term, to generate new knowledge about prevention, treatment and recovery from this infectious disease, and to investigate the broader societal issues concerning this pandemic. It is expected that the programme will be published at the end of April. In view of the considerable interest of the research into the coronavirus crisis, we would like to inform you in advance about the anticipated main lines of the programme.

Grant possibilities for research into coronavirus (COVID-19)

The programme will be funded by the Ministry of Health, Welfare and Sport, the Ministry of Education, Culture and Science and NWO. A budget of € 27 million has been made available for grants for research and practice-oriented projects. In this new programme, there will be room for various types of research (from fundamental to action research). Besides knowledge and practical solutions to limit the negative consequences of the pandemic, research is needed to learn from the negative and positive experiences, both now and in the longer term.

Three major focus areas covered in this COVID-19 research programme

This programme will concentrate on three major focus areas:

  1. Predictive diagnostics and treatment
  2. Care and prevention, including transmission 
  3. Societal consequences of the coronavirus crisis and the measures to prevent these

A further explanation of the focus areas will follow when the programme is announced (see timetable).
An expert panel is currently being formed for each focus area, made up of various experts from the field. These panels will contain scientific experts and experts from everyday practice. The panels will have the task of prioritising research subjects (or themes) within their focus area.

Approach

For each focus area, ZonMw will make grants available in three tracks:
For example, the ultrafast track will make funding available for questions that need to be tackled very urgently, also because the answers are needed for the control measures in this phase of the pandemic. For this track, invited proposals will be submitted as soon as possible. The second track is thematic, bottom-up funding rounds for research proposals. The third track is the so-called policy and practice boosts and is aimed at small projects and studies. This track is aimed at the (fast and brief) tackling of concrete policy questions and providing practice boosts.

It is expected that more detailed information about the COVID-19 programme will be made available on the ZonMw grant calendar at the end of April.

Timetable

  • At the end of April, the programme text for the entire programme will have been completed.
  • The announcement of the programme will take place via a news release at the end of April/start of May.
  • The awards for the urgent research proposals will be announced at the end of May.
  • The thematic funding rounds will be opened at the end of April/start of May.

More information

 

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news-5575 Wed, 15 Apr 2020 13:44:44 +0200 First approved research projects subsidy scheme COVID-19 https://www.zonmw.nl/nl/actueel/nieuws/detail/item/first-approved-research-projects-subsidy-scheme-covid-19/ Eight projects that will have a direct effect on the course of the coronavirus outbreak (COVID-19) and public health will soon be starting. This is the first result of the commission of the Ministry of Health, Welfare and Sport to ZonMw to finance critical research with a direct impact on the current corona pandemic. Top priority, quick action needed

Subjects have been inventoried and prioritised by an expert panel. Eight topics have been given top priority because they may have a direct impact on public health. Specific researchers were then asked to submit a research proposal on these topics. This (very) short application procedure was chosen because it was necessary to act quickly. Subsidies were granted to eight studies. A total budget of 5.5 million euro has been made available for this.

Funded projects

The projects that received an incidental subsidy cover the following subjects:

  1. 1Investigation into the course of the disease, long-term prognosis, cross-reactivity, re-infection, and the course of the immune response over time in relation to prognosis. To this end, a cohort of persons who have recovered from COVID-19 (RECoVERED study) will be followed.
  2. Research into carrier status, burden of disease and transmission from and to children (CoKids study).
  3. Research in the field of hospital epidemiology to support infection prevention measures (COCON study)
  4. A pharmacotherapeutic trial with anakinra in COVID-19 patients in intensive care (ANACOR-IC).
  5. Mapping virus evolution, spreading and transmission via sequencing to predict transmission routes.
  6. Social science research into the impact of social isolation on vulnerable populations and what support vulnerable groups need.
  7. Trial of chloroquine and hydroxychloroquine treatment in patients admitted for moderate to severe COVID-19 (ARCHAIC study).
  8. Drug development: studies into the safety and efficacy of antibodies to the coronavirus.

Almost all of the projects involve partnerships between several university medical centres, universities and other research institutions. It is important that they can start as soon as possible. More detailed project information can be found at https://www.zonmw.nl/en/about-zonmw/coronavirus/research-on-corona-and-covid-19/

Action and research programme COVID-19 and other grant possibilities

In addition to the incidental subsidies already provided, there are more granting possibilities. In order to meet the high demand for solutions and answers, ZonMw will soon start the research programme COVID-19 on behalf of VWS and together with NWO. This programme is aimed at preventing or reducing the negative effects of the COVID-19 pandemic, combating the pandemic and the social dynamics resulting from the pandemic. In this programme we make use of various granting mechanisms, including more open calls for proposals. These calls will appear on the ZonMw subsidy calendar. More information will follow in April.

Besides these initiatives, a scheme aimed at small projects with practical solutions for material shortages and other practical problems in and outside hospitals had also recently been started. In addition, the SET scheme was expanded. Both schemes have since been closed to new applications. The Virus Outbreak Data Access Network (VODAN) implementation network was also launched.

Important: Open access publications, especially at this time

Researchers are obliged to make all publications arising from scientific research that has been subsidised in whole or in part within this scheme immediately accessible through Open Access (without embargo) with an open license. In this way, we share new knowledge, that can contribute to improving public health regarding COVID-19, as quickly as possible. In addition, research results produced within this programme should be shared in line with the Joint statement on sharing research data and findings relevant to the novel coronavirus (nCoV) outbreak.

More information about ZonMw and the coronavirus

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